Results 31 to 40 of about 61,638 (306)
A circular network of purine metabolism as coregulators of dilated cardiomyopathy
Journal of Translational Medicine, 2022 Background The crosstalk of purine biosynthesis and metabolism exists to balance the cell energy production, proliferation, survival and cytoplasmic environment stability, but disorganized mechanics of with respect to developing heart failure (HF) is ...
Ge Wang +7 more
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Purine metabolism promotes radioresistance and is a therapeutic target in glioblastoma
Molecular & Cellular Oncology, 2020 Profound intratumoral genomic heterogeneity has limited the ability of targeted therapies to overcome therapy resistance in glioblastoma. We have defined purine metabolism as a key mediator of DNA repair and radiation resistance in glioblastoma.
Weihua Zhou, Daniel R Wahl
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Molecules, 2023 To explore the anti-hyperuricemia components in sunflower (Helianthus annuus L.) calathide extract (SCE), we identified abietic acid (AA) via liquid chromatography–mass spectrometry and found an excellent inhibitor of xanthine oxidase (IC50 = 10.60 µM ...
Huining Dai +5 more
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5′-Nucleotidase Plays a Key Role in Uric Acid Metabolism of Bombyx mori
Cells, 2021 Uric acid (UA) is the end-product in the human purine metabolism pathway. The UA that accumulates in silkworm tissues is excreted as a nitrogen waste product.
Linmeng Tang +11 more
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Purine metabolism in Echinococcus multilocularis
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 1998 The activities of the enzymes in Echinococcus multilocularis metacestodes involved in purine salvage were studied by HPLC. As in most parasites, this cestode relies entirely on salvage of preformed bases and nucleosides for its purine requirement. Therefore, these enzymes may be targets for drugs in the chemotherapeutic treatment of diseases caused by ...
Anne-Françoise Pétavy +2 more
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Research Progress in the Regulation of Gut Microbiota on Diet-Induced Hyperuricemia
Shipin gongye ke-ji, 2022 Hyperuricemia is a metabolic disease with excessively high level of uric acid in blood. It is triggered by the disorder of purine metabolism and/or uric acid excretion in human, and the purine-rich and fructose-rich diets and purine was confirmed to ...
Yingping MENG +3 more
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Computer simulation of purine metabolism [PDF]
European Journal of Biochemistry, 1984 A computer model of purine metabolism, including catabolism, salvage pathways and interconversion among nucleotides, is given. Steady‐state rate equations corresponding to metabolic enzymes are written based on information from the literature about their kinetic behaviour.
Rafael Franco, Enrique I. Canela
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Identifying prognostic targets in metastatic prostate cancer beyond AR
FEBS Open Bio, EarlyView.Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng +13 more
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Epilepsia Open, EarlyView., 2022 Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines.
Laura Bindila +11 more
wiley +1 more source
FoodsBackground: Excessive purine intake increases the risk of hyperuricemia and gout. This study investigates the relationship between purine content in mutton and meat quality traits and explores the regulatory mechanism of purine metabolism through ...
Xu Han +8 more
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