Results 51 to 60 of about 61,638 (306)

Regulation of Purine Metabolism in Lymphocytes

Experimental Biology and Medicine, 1985
Three general questions regarding nucleosides and lymphocytes are discussed: (a) Why are so many measurements being made of adenosine deaminase activity, what do the results mean, and why is there still disagreement about some of the conclusions; (b) what do we understand about nucleosides and lymphocyte death; and (c) to what extent do we really ...
Camilla M. Smith, J F Henderson, George Zombor   +2 more
openaire   +3 more sources

Purine metabolism in Methanococcus vannielii [PDF]

Journal of Bacteriology, 1993
Methanococcus vannielii is capable of degrading purines to the extent that each of these purines may serve as the sole nitrogen source for growth. Results presented here demonstrate that purine degradation by M. vannielii is accomplished by a route similar to that described for clostridia.
T Auffenberg, Edward DeMoll
openaire   +3 more sources

Metabolic Stress‐Induced Choline Kinase α (CHKA) Activation in Endothelial Subpopulation Contributes to Diabetes‐Associated Microvascular Dysfunction

Advanced Science, EarlyView.
This study uncovers CHKA as a pivotal driver of vascular dysfunction in diabetic retinopathy and highlights its role in endothelial dysfunction through NAD⁺‐SIRT1‐Notch signaling. Single‐cell and functional analyses, combined with clinical and genetic validation, suggest CHKA as a promising therapeutic target for the prevention and treatment of ...
Ling Ren, Linyu Zhang, Yun Bai, Chang Huang, Xiaosa Li, Fanfei Ma, Wan Mu, Mudi Yao, Chang Jiang, Xiangjun Chen, Qin Jiang, Biao Yan   +11 more
wiley   +1 more source

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

Advanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu   +9 more
wiley   +1 more source

Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing

Nature Communications
Supporting cell proliferation through nucleotide biosynthesis is an essential requirement for cancer cells. Hence, inhibition of folate-mediated one carbon (1C) metabolism, which is required for nucleotide synthesis, has been successfully exploited in ...
Martha M. Zarou, Kevin M. Rattigan, Daniele Sarnello, Engy Shokry, Amy Dawson, Angela Ianniciello, Karen Dunn, Mhairi Copland, David Sumpton, Alexei Vazquez, G. Vignir Helgason   +10 more
doaj   +1 more source

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

Fusobacterium nucleatum-triggered purine metabolic reprogramming drives tumorigenesis in head and neck carcinoma

Discover Oncology, 2023
Background Fusobacterium nucleatum (F. nucleatum) is a vital pro-oncogenic bacterium. Our previous study revealed that a high abundance of F. nucleatum in head and neck squamous cell carcinoma (HNSCC) is correlated with poor patient prognosis.
Feiran Li, Huiying Huang, Jing Xu, Lei Tao, Liang Zhou, Chiyao Hsueh, Hongli Gong, Ming Zhang   +7 more
doaj   +1 more source

FLASH Irradiation Modulates Immune Responses and Accelerates Lung Recovery: A Single‐Cell Perspective

Advanced Science, EarlyView.
Single‐cell RNA sequencing reveals distinct immune responses to FLASH versus conventional dose rate irradiation in early radiation‐induced lung injury. FLASH irradiation reduces Ccrl2⁺ neutrophil infiltration, activates CD4⁺ CD40L⁺ Th cells, restrains pro‐inflammatory Mefv⁺ monocytes, and enhances epithelial repair via TGF‐β signaling, underscoring its
Hao Lu, Menghua Li, Cheng Quan, Caihui Li, Dawei Li, Zhihui Li, Jing Xu, Lihui Zhang, Qixiang Liu, Guofu Dong, Changzhen Wang   +10 more
wiley   +1 more source

A Touch Enabled Hemodynamic and Metabolic Monitor

Advanced Science, EarlyView.
This work presents a touch‐based hybrid platform for simultaneous monitoring of vital signs and sweat metabolites. With a simple tri‐finger touch of 4–6 min, users can concurrently get to know their glucose, uric acid, cortisol levels from fingertip sweat, along with blood pressure and heart rate.
Omeed Djassemi, Tamoghna Saha, Ponnusamy Nandhakumar, Muhammad Inam Khan, Hannah Fishman, Sara Earney, Chochanon Moonla, Yuchen Xu, Henry Thai, Sofia Morales‐Fermin, Gyeongho Kim, Rhea Park, Beya Acot, Oscar Wu, Cannon Wurster, An‐Yi Chang, Christopher Cheung, Julia Silberman, Shichao Ding, Joseph Wang   +19 more
wiley   +1 more source

Conditional Stabilization of the Hypoxia‐Inducible Factor HIF1α— Photoswitchable Stapled Peptides Prevent Elongin BC–Mediated Degradation

Angewandte Chemie, EarlyView.
Visible‐light photoswitchable peptides enable the stabilization of the hydroxylated hypoxia transcription factor 1α (HIF1α—OH) by targeting the pVHL‐EloBC interaction. Significant differences in conformation, binding, and transcription of HIF‐targeted genes between the photostationary states (PSS) were demonstrated.
Van Tuan Trinh, Sabrina Fischer, Lei Zhang, Heiko Geisler, Belen Pardo, Robert Liefke, Frank Abendroth, Olalla Vázquez   +7 more
wiley   +2 more sources