Results 61 to 70 of about 1,020,918 (293)

Investigating the Vital Role of the Identified Abietic Acid from Helianthus annuus L. Calathide Extract against Hyperuricemia via Human Embryonic Kidney 293T Cell Model

Molecules, 2023
To explore the anti-hyperuricemia components in sunflower (Helianthus annuus L.) calathide extract (SCE), we identified abietic acid (AA) via liquid chromatography–mass spectrometry and found an excellent inhibitor of xanthine oxidase (IC50 = 10.60 µM ...
Huining Dai, Xiao Xu, Wannan Li, Xueqi Fu, Weiwei Han, Guodong Li   +5 more
doaj   +1 more source

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

Advanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel Metzger, Delphine Duteil   +11 more
wiley   +1 more source

Sex‐ and Time‐Resolved Physiological and Gut Ecosystem Responses to a Food‐Grade Microbiome‐Targeted Intervention in Collegiate Endurance Athletes

Advanced Science, EarlyView.
In collegiate endurance athletes, a 6‐week randomized CPYE intervention yielded time‐ and sex‐dependent shifts in field‐based cardiorespiratory, metabolic, and redox indices, accompanied by changes in gut multi‐omics profiles. An exploratory extension during intensified training generates hypotheses warranting future validation.
Meng Zhang, Le Ge, Kaiyang Liu, Yanrong Liu, Guolin Zhao, Lai‐Yu Kwok, Zheng Sun, Zhihong Sun, Wenyi Zhang   +8 more
wiley   +1 more source

Purine Metabolism in Acute Cerebral Ischemia

Общая реаниматология, 2008
Objective: to study the specific features of purine metabolism in clinically significant acute cerebral ischemia. Subjects and materials. Three hundred and fifty patients with the acutest cerebral ischemic stroke were examined.
Ye. V. Oreshnikov, S. F. Oreshnikova, I. V. Madyanov   +2 more
doaj   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

Unveiling the Complete Biosynthetic Pathway of Azacitidine: A Rare 1,3,5‐Triazine Nucleoside Derived From GTP

Angewandte Chemie, EarlyView.
The azacitidine biosynthetic gene cluster (aza BGC) was identified by the resistance‐gene‐guided comparative genomics method in Streptomyces mobaraensis IPIO2. The complete biosynthetic pathway of azacitidine, which follows a “base‐first‐then‐glycosylation” logic, was elucidated through in vivo and in vitro experiments.
Dan Wang, Qingxu Meng, Lingqi Hua, Mengjun Sun, Qianjin Kang, Min‐Juan Xu, Linquan Bai   +6 more
wiley   +2 more sources

Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing

Nature Communications
Supporting cell proliferation through nucleotide biosynthesis is an essential requirement for cancer cells. Hence, inhibition of folate-mediated one carbon (1C) metabolism, which is required for nucleotide synthesis, has been successfully exploited in ...
Martha M. Zarou, Kevin M. Rattigan, Daniele Sarnello, Engy Shokry, Amy Dawson, Angela Ianniciello, Karen Dunn, Mhairi Copland, David Sumpton, Alexei Vazquez, G. Vignir Helgason   +10 more
doaj   +1 more source

The influence of testosterone on purine nucleotide metabolism in rat liver

, 1995
Purine nucleotide metabolism was studied in rat liver by following the incorporation of 14C-formate into soluble nucleotides, uric acid and RNA ribonucleotides.
Leoncini R., Pizzichini M., Vannoni D., Pagani R., Marinello E., M. Pizzichini, E. Marinello, R. Pagani, D. Vannoni, R. Leoncini   +9 more
core   +1 more source

Ammonification Process Is Limited by Transformation of Medium Molecular Weight Nitrogenous Organics but Not Hydrolysis of Proteins

Advanced Science, EarlyView.
A multi‐level analytical framework, integrating protein‐level persistence analysis, nontargeted HRMS formula tracking, peptide‐level proteomics, and targeted monomer quantification under varying redox conditions, together with FMO calculations reveal that ammonification is limited by medium molecular weight nitrogenous multimers.
Jing Li, Junjie Qiu, Fan Lü, Hua Zhang, Pinjing He   +4 more
wiley   +1 more source

An IscS Persulfide Donates the Sulfur for Ribosomal Protein uL16 Thioamidation

Angewandte Chemie, EarlyView.
YcaO‐catalyzed thioamidation of the ribosomal subunit protein uL16 is widespread in Pseudomonadota bacteria. We identify the iron–sulfur cluster cysteine desulfurase IscS as the sulfur donor via an IscS persulfide and observe direct IscS–uL16 interactions.
Yanqing Xue, Markus W. Voehler, Douglas A. Mitchell   +2 more
wiley   +2 more sources