Results 81 to 90 of about 61,638 (306)
Pharmacogenomics in the UK National Health Service: Progress towards implementation
British Journal of Clinical Pharmacology, EarlyView.Over the past decade there has been considerable and growing enthusiasm about the promise of using genomics to inform healthcare. In particular, using genetic data to inform prescribing practice has emerged as a compelling policy priority for health systems around the world, not least in the NHS.
John H. McDermott +3 more
wiley +1 more source
Purine and pyrimidine nucleotide metabolism in Mollicutes
Genetics and Molecular Biology, 2007 Several mollicute genome projects are underway, offering unique opportunities to study genes and metabolic pathways on a genome-wide scale. Here, we have analyzed the conservation and diversity of purine and pyrimidine metabolism in mycoplasmas.
Cristiano Valim Bizarro +1 more
doaj +1 more source
Purine Metabolism in Toxoplasma gondii
Journal of Biological Chemistry, 1989 We have studied the incorporation and interconversion of purines into nucleotides by freshly isolated Toxoplasma gondii. They did not synthesize nucleotides from formate, glycine, or serine. The purine bases hypoxanthine, xanthine, guanine, and adenine were incorporated at 9.2, 6.2, 5.1, and 4.3 pmol/10(7) cells/h, respectively.
Randolph L. Berens +2 more
openaire +3 more sources
RSEA: A Web Server for Pathway Enrichment Analysis of Metabolic Reaction Sets
Biotechnology and Bioengineering, EarlyView.Reaction Set Enrichment Analysis (RSEA), a web server tool designed for metabolic pathway enrichment analysis of reaction sets derived from genome‐scale metabolic models was introduced. RSEA converts given reaction lists into standardized identifiers and statistically evaluates their enrichment across metabolic pathways.
Merve Yarıcı +4 more
wiley +1 more source
STUDIES ON PURINE METABOLISM IN BACTERIA I [PDF]
, 1952 Joseph S. Gots, Eileen Chu
openalex +1 more source
Biotechnology and Bioengineering, EarlyView.The authors present a streamlined cascade reaction for one‐pot N‐C rearrangement of uridine‐5′‐phosphate (UMP) to pseudouridine‐5′‐phosphate (ΨMP; a key mRNA vaccine building block), in two enzymatic steps catalyzed by UMP nucleosidase (EC 3.2.2.10) and ΨMP C‐glycosidase (EC 4.2.1.70).
Martin Pfeiffer +2 more
wiley +1 more source
Metabolomics Based Identification of SIRT5 and Protein Kinase C Epsilon Regulated Pathways in Brain
Frontiers in Neuroscience, 2018 The role of Sirtuins in brain function is emerging, yet little is known about SIRT5 in this domain. Our previous work demonstrates that protein kinase C epsilon (PKCε)-induced protection from focal ischemia is lost in SIRT5−/− mice.
Kevin B. Koronowski +15 more
doaj +1 more source
PCFT‐Independent Cellular Uptake of Cyclic Cell‐Penetrating Peptide‐Conjugated Folic Acid
ChemBioChem, EarlyView.Cell‐penetrating peptide (CPP)‐conjugated folic acid mediates efficient internalization of folic acid that is independent of the presence of proton‐coupled folate transporter (PCFT) on the intestinal cells. CPP‐conjugated folic acid demonstrates superior cellular uptake at all studied pH and in the presence of PCFT inhibitors and shows enhanced ...
Vineet Kumar Mishra +3 more
wiley +1 more source
Studies on the biosynthesis of riboflavin. 4. Purine metabolism and riboflavin synthesis in Eremothecium ashbyii [PDF]
, 1958 Eric G. Brown +2 more
openalex +1 more source
ChemPlusChem, EarlyView.The article evaluates polyoxometalate–ionic liquids (POM–ILs) as biocidal agents against lampenflora in the UNESCO‐listed Pommery Champagne cellar. POM–ILs effectively inhibit microbial colonization over one year with minimal visual impact and outperform the commercial biocide Preventol RI80.
Stéphanie Eyssautier‐Chuine +10 more
wiley +1 more source