Acid- and base-catalyzed ring-opening reactions or a sterically hindered epoxide [PDF]
, 1987 Bäuml, Englbert +3 more
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Immunization with purine salvation pathway recombinant enzymes induces the production of anti- Schistosoma mansoni immunoglobulines [PDF]
Schistosomiasis, a disease caused by the trematodes of the Schistosoma genus, affects about 240 million people worldwide. The Praziquantel (PZQ) is the drug used to treat this disease. However, reports of resistant strains reinforce the need to develop a
Adachi, Felipe de Pontes +10 more
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Structure of E. coli 5′-methylthioadenosine/S-adenosylhomocysteine Nucleosidase Reveals Similarity to the Purine Nucleoside Phosphorylases [PDF]
, 2001 Jeffrey E. Lee +3 more
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Adenosine deaminase from Plasmodium falciparum as a Potential Drug Target in Anti- Malarial Drug Designing: A Bioinformatic Approach [PDF]
, 2009 Parasites are responsible for a wide variety of infectious diseases causing an enormous health and economical blight. Malaria is one such prominent disease that causes widespread infections in humans and results in innumerable deaths annually.
Meenaa, V. +3 more
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Mechanisms of cell death induced by suicide genes encoding purine nucleoside phosphorylase and thymidine kinase in human hepatocellular carcinoma cells in vitro [PDF]
, 2001 Tim U. Krohne +6 more
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A resistant mutant of Plasmodium falciparum purine nucleoside phosphorylase uses wild-type neighbors to maintain parasite survival. [PDF]
J Biol Chem, 2021 Minnow YVT, Harijan RK, Schramm VL.
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Submolecular characterization of a mutant human purine-nucleoside phosphorylase.
, 1980 James A. McRoberts, David W. Martin
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Single tryptophan Y160W mutant of homooligomeric E. coli purine nucleoside phosphorylase implies that dimers forming the hexamer are functionally not equivalent. [PDF]
Sci Rep, 2021 Narczyk M +7 more
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