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Symmetric Nucleosides as Potent Purine Nucleoside Phosphorylase Inhibitors.
The Journal of Physical Chemistry B, 2021Nucleic acids are one of the most enigmatic biomolecules crucial to several biological processes. Nucleic acid-protein interactions are vital for the coordinated and controlled functioning of a cell, leading to the design of several nucleoside/nucleotide
Pradeep Pant, A. Pathak, B. Jayaram
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LINGCOD MUSCLE PURINE NUCLEOSIDE PHOSPHORYLASE
Canadian Journal of Biochemistry and Physiology, 1958A purine nucleoside phosphorylase enzyme preparation, which catalyzed the general reaction ribose (deoxyribose) [Formula: see text] nucleoside (deoxynucleoside)+orthophosphate, was isolated from muscles of the lingcod (Ophiodon elongatus). The reaction was found to be about 85% in favor of nucleoside synthesis with 10 μM./ml.
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Purine nucleoside phosphorylase of chicken liver
Biochimica et Biophysica Acta (BBA) - Enzymology, 1971Abstract Purine nucleoside phosphorylase (purine nucleoside:orthophosphate ribosyltransferase, EC 2.4.2.1) has been purified 125-fold from the homogenate of chicken livers and some of the properties of the purified enzyme have been studied. This enzyme had a pH optimum at around 6.o. At high substrate levels of inosine the reaction rate was increased,
K, Murakami, A, Mitsui, K, Tsushima
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Purine Nucleoside Phosphorylase. 2. Catalytic Mechanism
Biochemistry, 1997X-ray crystallography, molecular modeling, and site-directed mutagenesis were used to delineate the catalytic mechanism of purine nucleoside phosphorylase (PNP). PNP catalyzes the reversible phosphorolysis of purine nucleosides to the corresponding purine base and ribose 1-phosphate using a substrate-assisted catalytic mechanism.
M D, Erion +4 more
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Purine nucleoside phosphorylase from bovine liver
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 19781. Purine nucleoside phosphorylase (purine nucleoside:orthophosphate ribosyltransferase, E.C. 2.4.2.1) from liver of cattle, Bos taurus, was purified to homogeneity. Some properties of the enzymes from three different bovine tissues were compared and discussed. 2.
Z, Ikezawa +3 more
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Mutations in purine nucleoside phosphorylase deficiency
Human Mutation, 1997Purine nucleoside phosphorylase deficiency is an inherited disease of purine metabolism characterized clinically as combined immunodeficiency. The molecular defects have been published for 4 different alleles in 3 patients. We report four new mutations including two amino acid substitutions, A174P and G190V, a single codon deletion, delta I129, and a ...
M L, Markert +8 more
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Allosteric regulation of purine nucleoside phosphorylase
Archives of Biochemistry and Biophysics, 1991Purine nucleoside phosphorylase (EC 2.4.2.1) from bovine spleen is allosterically regulated. With the substrate inosine the enzyme displayed complex kinetics: positive cooperativity vs inosine when this substrate was close to physiological concentrations, negative cooperativity at inosine concentrations greater than 60 microM, and substrate inhibition ...
P A, Ropp, T W, Traut
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Stroke in purine nucleoside phosphorylase deficiency
Pediatric Neurology, 1995The first documented case of cerebrovascular disease occurring in a 13-year-old girl with purine nucleoside phosphorylase deficiency is reported. This patient, the oldest known survivor with purine nucleoside phosphorylase deficiency, had previously experienced multiple sequential neurologic problems.
D A, Tam, R T, Leshner
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Prenatal exclusion of purine nucleoside phosphorylase deficiency
European Journal of Pediatrics, 1986We report on the prenatal exclusion of purine nucleoside phosphorylase (PNP) deficiency in a fetus whose parents were known to be heterozygotes for the enzyme defect. Prenatal investigation was performed in the 16th week of gestation on amniotic fluid and cultured amnion cells using sensitive techniques.
E. Carapella De Luca +6 more
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