Results 11 to 20 of about 17,987 (161)

Synthesis of New 5′-Norcarbocyclic Aza/Deaza Purine Fleximers - Noncompetitive Inhibitors of E.coli Purine Nucleoside Phosphorylase [PDF]

Frontiers in Chemistry, 2022
A new series of flexible 5′-norcarbocyclic aza/deaza-purine nucleoside analogs were synthesized from 6-oxybicyclo[3.1.0.]hex-2-ene and pyrazole-containing fleximer analogs of heterocyclic bases using the Trost procedure.
Anastasia Khandazhinskaya, Ilja Fateev, Irina Konstantinova, Roman Esipov, Konstantin Polyakov, Katherine Seley-Radtke, Sergey Kochetkov, Elena Matyugina   +7 more
doaj   +2 more sources

Early Diagnosis and Treatment of Purine Nucleoside Phosphorylase (PNP) Deficiency through TREC-Based Newborn Screening [PDF]

International Journal of Neonatal Screening, 2021
Purine nucleoside phosphorylase (PNP) deficiency is a rare inherited disorder, resulting in severe combined immunodeficiency. To date, PNP deficiency has been detected in newborn screening only through the use of liquid chromatography tandem mass ...
Andrea Martín-Nalda, Jacques G. Rivière, Mireia Català-Besa, Marina García-Prat, Alba Parra-Martínez, Mónica Martínez-Gallo, Roger Colobran, Ana Argudo-Ramírez, Jose Luis Marín-Soria, Judit García-Villoria, Laura Alonso, Jose Antonio Arranz-Amo, Giancarlo la Marca, Pere Soler-Palacín   +13 more
doaj   +2 more sources

Chemo-Enzymatic Generation of Highly Fluorescent Nucleoside Analogs Using Purine-Nucleoside Phosphorylase [PDF]

Biomolecules
Chemo-enzymatic syntheses of strongly fluorescent nucleoside analogs, potentially applicable in analytical biochemistry and cell biology are reviewed. The syntheses and properties of fluorescent ribofuranosides of several purine, 8-azapurine, and etheno ...
Alicja Stachelska-Wierzchowska, Jacek Wierzchowski   +1 more
doaj   +2 more sources

Purine nucleoside phosphorylase dominates Influenza A virus replication and host hyperinflammation through purine salvage [PDF]

Signal Transduction and Targeted Therapy
Influenza A virus (IAV) poses a significant threat to human health. The outcome of IAV results from the viral-host interaction, with the underlying molecular mechanisms largely unknown.
Yang Yue, Qingyu Li, Changguo Chen, Juntao Yang, Weian Song, Changdong Zhou, Yuke Cui, Zhenqiao Wei, Qi He, Chenhui Wang, Hongjun Lin, Jiangbo Li, Jian Li, Ji Xi, Xiang Song, Wen Yang, Ze Zhang, Wenjie Shu, Liang Guo, Shengqi Wang   +19 more
doaj   +2 more sources

Recurrent infections, neurologic signs, low serum uric acid levels, and lymphopenia in childhood: Purine nucleoside phosphorylase deficiency, an emergency for infants [PDF]

Turk Pediatri Ars, 2020
Purine nucleoside phosphorylase deficiency is one of the severe combined immunodeficiencies, which often clinically manifests with recurrent infections, neurologic symptoms and autoimmune diseases, and leads to thymocyte development and peripheral T cell
N. Kütükçüler, Ezgi Bölük, Nazan Tökmeci, N. Karaca, E. Azarsız, G. Aksu, A. Aykut   +6 more
semanticscholar   +2 more sources

Synthesis of Substituted 1,2,4-Triazole-3-Thione Nucleosides Using E. coli Purine Nucleoside Phosphorylase [PDF]

Biomolecules
1,2,4-Triazole derivatives have a wide range of biological activities. The most well-known drug that contains 1,2,4-triazole as part of its structure is the nucleoside analogue ribavirin, an antiviral drug. Finding new nucleosides based on 1,2,4-triazole
Ilya V. Fateev, Sobirdjan A. Sasmakov, Jaloliddin M. Abdurakhmanov, Abdukhakim A. Ziyaev, Shukhrat Sh. Khasanov, Farkhod B. Eshboev, Oybek N. Ashirov, Valeriya D. Frolova, Barbara Z. Eletskaya, Olga S. Smirnova, Maria Ya. Berzina, Alexandra O. Arnautova, Yulia A. Abramchik, Maria A. Kostromina, Alexey L. Kayushin, Konstantin V. Antonov, Alexander S. Paramonov, Valeria L. Andronova, Georgiy A. Galegov, Roman S. Esipov, Shakhnoz S. Azimova, Anatoly I. Miroshnikov, Irina D. Konstantinova   +22 more
doaj   +2 more sources

Evaluating antitumor activity of Escherichia coli purine nucleoside phosphorylase against head and neck patient‐derived xenografts [PDF]

Cancer Reports, 2023
Background Purine nucleoside phosphorylase (PNP) gene transfer represents a promising approach to treatment of head and neck malignancies. We tested recombinant adenovirus already in phase I/II clinical testing and leading‐edge patient‐derived xenografts
Regina Rab, Annette Ehrhardt, Bhagelu R. Achyut, Disha Joshi, Melissa Gilbert‐Ross, Chunzi Huang, Katharine Floyd, Anton V. Borovjagin, William B. Parker, Eric J. Sorscher, Jeong S. Hong   +10 more
doaj   +2 more sources

The Characterization of the Purine Nucleoside Phosphorylase from Agaricus bisporus and Its Potential Application in Reducing Purine Content in Beer [PDF]

Journal of Fungi
Beer, the most popular alcoholic beverage, poses health risks for individuals with gout and hyperuricemia due to its high purine content. Herein, we identified a novel purine nucleoside phosphorylase (AbPNP) from the edible mushroom Agaricus bisporus and
Jun Liu, Jian Lu
doaj   +2 more sources

Purine nucleoside phosphorylase as a target for the treatment of interstitial cystitis/bladder pain syndrome with and without Hunner lesions [PDF]

Scientific Reports
Chronic visceral pain disorders, such as interstitial cystitis/bladder pain syndrome (IC/BPS), are difficult to treat, and therapies are limited in number and efficacy.
Lori A. Birder, Amanda Wolf-Johnston, Vladimir Ritov, Joel N. H. Stern, Robert Moldwin, Hann-Chorng Kuo, Edwin K. Jackson   +6 more
doaj   +2 more sources

Purine nucleoside phosphorylase as a target to treat age-associated lower urinary tract dysfunction [PDF]

Nat Rev Urol, 2022
L. Birder, E. Jackson
semanticscholar   +2 more sources