Synthesis of New 5′-Norcarbocyclic Aza/Deaza Purine Fleximers - Noncompetitive Inhibitors of E.coli Purine Nucleoside Phosphorylase [PDF]
Frontiers in Chemistry, 2022 A new series of flexible 5′-norcarbocyclic aza/deaza-purine nucleoside analogs were synthesized from 6-oxybicyclo[3.1.0.]hex-2-ene and pyrazole-containing fleximer analogs of heterocyclic bases using the Trost procedure.
Anastasia Khandazhinskaya +7 more
doaj +2 more sources
Early Diagnosis and Treatment of Purine Nucleoside Phosphorylase (PNP) Deficiency through TREC-Based Newborn Screening [PDF]
International Journal of Neonatal Screening, 2021 Purine nucleoside phosphorylase (PNP) deficiency is a rare inherited disorder, resulting in severe combined immunodeficiency. To date, PNP deficiency has been detected in newborn screening only through the use of liquid chromatography tandem mass ...
Andrea Martín-Nalda +13 more
doaj +2 more sources
Science Translational Medicine, 2019 A cellular thermal shift assay (CETSA) protocol identifies and resolves antimalarial drug targets in P. falciparum. Defining drug targets in malaria Different classes of malaria drugs have been used for decades, even though the mechanisms of action have ...
Jerzy Michal Dziekan, Han Yu, Dan Chen
exaly +2 more sources
Chemo-Enzymatic Generation of Highly Fluorescent Nucleoside Analogs Using Purine-Nucleoside Phosphorylase [PDF]
BiomoleculesChemo-enzymatic syntheses of strongly fluorescent nucleoside analogs, potentially applicable in analytical biochemistry and cell biology are reviewed. The syntheses and properties of fluorescent ribofuranosides of several purine, 8-azapurine, and etheno ...
Alicja Stachelska-Wierzchowska +1 more
doaj +2 more sources
Recurrent infections, neurologic signs, low serum uric acid levels, and lymphopenia in childhood: Purine nucleoside phosphorylase deficiency, an emergency for infants. [PDF]
Turk Pediatri Ars, 2020 Purine nucleoside phosphorylase deficiency is one of the severe combined immunodeficiencies, which often clinically manifests with recurrent infections, neurologic symptoms and autoimmune diseases, and leads to thymocyte development and peripheral T cell
Kütükçüler N +6 more
europepmc +2 more sources
[Purine nucleoside phosphorylase]. [PDF]
Biomeditsinskaya Khimiya, 2013 Purine nucleoside phosphorylase (PNP) is one of the most important enzymes of the purine metabolism, wich promotes the recycling of purine bases. Nowadays is the actual to search for effective inhibitors of this enzyme which is necessary for creation T-cell immunodeficient status of the organism in the organs and tissues transplantation, and ...
L. Pogosian, Zh I Akopian
semanticscholar +3 more sources
Structural determinants of the 5'-methylthioinosine specificity of Plasmodium purine nucleoside phosphorylase. [PDF]
PLoS ONE, 2014 Plasmodium parasites rely upon purine salvage for survival. Plasmodium purine nucleoside phosphorylase is part of the streamlined Plasmodium purine salvage pathway that leads to the phosphorylysis of both purines and 5'-methylthiopurines, byproducts of ...
Teraya M Donaldson +6 more
doaj +2 more sources
Purine nucleoside phosphorylase (PNP) deficiency: across-the-board severe combined immunodeficiency [PDF]
Egyptian Journal of Medical Human GeneticsBackground Purine nucleoside phosphorylase (PNP) deficiency is a rare, autosomal recessive, inborn error of immunity. It is characterized by progressive immune abnormalities ranging from severe combined immunodeficiency (SCID) to combined ...
Engy A. Chohayeb +6 more
doaj +2 more sources
Purine nucleoside phosphorylase dominates Influenza A virus replication and host hyperinflammation through purine salvage [PDF]
Signal Transduction and Targeted TherapyInfluenza A virus (IAV) poses a significant threat to human health. The outcome of IAV results from the viral-host interaction, with the underlying molecular mechanisms largely unknown.
Yang Yue +19 more
doaj +2 more sources
Purine nucleoside phosphorylase as a target to treat age-associated lower urinary tract dysfunction. [PDF]
Nat Rev Urol, 2022 Birder LA, Jackson EK.
europepmc +2 more sources