Conservation of structure and activity in Plasmodium purine nucleoside phosphorylases [PDF]
BMC Structural Biology, 2009 Background Purine nucleoside phosphorylase (PNP) is central to purine salvage mechanisms in Plasmodium parasites, the causative agents of malaria. Most human malaria results from infection either by Plasmodium falciparum (Pf), the deadliest form of the ...
Brady, R Leo, Chaikuad, Apirat
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Purine Nucleoside Phosphorylase as a Cytosolic Arsenate Reductase [PDF]
Toxicological Sciences, 2002 The findings of the accompanying paper (Németi and Gregus, Toxicol: Sci. 70, 4-12) indicate that the arsenate (AsV) reductase activity of rat liver cytosol is due to an SH enzyme that uses phosphate (or its analogue, arsenate, AsV) and a purine nucleoside (guanosine or inosine) as substrates. Purine nucleoside phosphorylase (PNP) is such an enzyme.
Zoltán Gregus
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Immunodeficiency, motor delay, and hypouricemia caused by a novel mutation of purine nucleoside phosphorylase gene in an Indian infant [PDF]
Annals of Indian Academy of Neurology, 2019 We describe an 11-month-old boy who presented with recurrent respiratory infections from 6 months of age. His elder sister died at 10 months with severe septicemia and meningitis. The boy had a mild motor delay.
Nikit Shah +5 more
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Engineering a Bifunctional Fusion Purine/Pyrimidine Nucleoside Phosphorylase for the Production of Nucleoside Analogs [PDF]
BiomoleculesNucleoside phosphorylases (NPs) are pivotal enzymes in the salvage pathway, catalyzing the reversible phosphorolysis of nucleosides to produce nucleobases and α-D-ribose 1-phosphate.
Daniel Hormigo +4 more
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Purine nucleoside phosphorylase controls nicotinamide riboside metabolism in mammalian cells. [PDF]
J Biol Chem, 2022 Kropotov A +13 more
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Nucleotide analogue inhibitors of purine nucleoside phosphorylase.
Journal of Biological Chemistry, 1990 The diphosphate of the antiherpetic agent acyclovir [9-[(2-hydroxyethoxy)methyl]guanine] has been shown to inhibit purine nucleoside phosphorylase with unique potency (Tuttle, J. V., and Krenitsky, T. A. (1984) J. Biol. Chem. 259, 4065-4069). A major factor contributing to the superior inhibition by this diphosphate over the corresponding mono- and ...
Thomas A. Krenitsky +5 more
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A trimeric structure for mammalian purine nucleoside phosphorylase [PDF]
FEBS Letters, 1973 Yvonne H. Edwards +2 more
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Purine nucleoside phosphorylase targeted by annexin v to breast cancer vasculature for enzyme prodrug therapy. [PDF]
PLoS ONE, 2013 BACKGROUND AND PURPOSE: The targeting of therapeutics is a promising approach for the development of new cancer treatments that seek to reduce the devastating side effects caused by the systemic administration of current drugs.
John J Krais +2 more
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Purine nucleoside phosphorylase deficiency in two unrelated Saudi patients
Annals of Saudi Medicine, 2009 Purine nucleoside phosphorylase (PNP) deficiency is a rare autosomal recessive metabolic disorder that results in combined immunodeficiency, neurologic dysfunction and autoimmunity.
Alangari Abdullah +4 more
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Metabolites of purine nucleoside phosphorylase (NP) in serum have the potential to delineate pancreatic adenocarcinoma. [PDF]
PLoS ONE, 2011 Pancreatic Adenocarcinoma (PDAC), the fourth highest cause of cancer related deaths in the United States, has the most aggressive presentation resulting in a very short median survival time for the affected patients. Early detection of PDAC is confounded
Shaiju K Vareed +19 more
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