Radical Dehalogenation and Purine Nucleoside Phosphorylase E. coli: How Does an Admixture of 2′,3′-Anhydroinosine Hinder 2-fluoro-cordycepin Synthesis [PDF]
Biomolecules, 2021 During the preparative synthesis of 2-fluorocordycepin from 2-fluoroadenosine and 3′-deoxyinosine catalyzed by E. coli purine nucleoside phosphorylase, a slowdown of the reaction and decrease of yield down to 5% were encountered.
Alexey L. Kayushin +12 more
doaj +2 more sources
Crystallographic snapshots of ligand binding to hexameric purine nucleoside phosphorylase and kinetic studies give insight into the mechanism of catalysis. [PDF]
Sci Rep, 2018 Purine nucleoside phosphorylase (PNP) catalyses the cleavage of the glycosidic bond of purine nucleosides using phosphate instead of water as a second substrate.
Štefanić Z +5 more
europepmc +2 more sources
Use of E. coli Purine Nucleoside Phosphorylase in the Treatment of Solid Tumors. [PDF]
Curr Pharm Des, 2017 BACKGROUND The selective expression of non-human genes in tumor tissue to activate non-toxic compounds (Gene Directed Prodrug Enzyme Therapy, GDEPT) is a novel strategy designed for killing tumor cells in patients with little or no systemic toxicity ...
Parker WB, Sorscher EJ.
europepmc +2 more sources
Propolis Exerts an Anti-Inflammatory Effect on PMA-Differentiated THP-1 Cells via Inhibition of Purine Nucleoside Phosphorylase. [PDF]
Metabolites, 2019 Previous research has shown that propolis has immunomodulatory activity. Propolis extracts from different geographic origins were assessed for their anti-inflammatory activities by investigating their ability to alter the production of tumour necrosis ...
Alqarni AM +6 more
europepmc +2 more sources
Purine nucleoside phosphorylase deficiency
Atlas of Inherited Metabolic Diseases, 2020 People with purine nucleoside phosphorylase deficiency have low numbers of immune system cells called T cells, which normally recognize and attack foreign invaders to prevent infection.
C. Staufner
semanticscholar +2 more sources
Purine Nucleoside Phosphorylase as a Cytosolic Arsenate Reductase [PDF]
Toxicological Sciences, 2002 The findings of the accompanying paper (Németi and Gregus, Toxicol: Sci. 70, 4-12) indicate that the arsenate (AsV) reductase activity of rat liver cytosol is due to an SH enzyme that uses phosphate (or its analogue, arsenate, AsV) and a purine nucleoside (guanosine or inosine) as substrates. Purine nucleoside phosphorylase (PNP) is such an enzyme.
Zoltán Gregus
openalex +4 more sources
Immunodeficiency, motor delay, and hypouricemia caused by a novel mutation of purine nucleoside phosphorylase gene in an Indian infant [PDF]
Annals of Indian Academy of Neurology, 2019 We describe an 11-month-old boy who presented with recurrent respiratory infections from 6 months of age. His elder sister died at 10 months with severe septicemia and meningitis. The boy had a mild motor delay.
Nikit Shah +5 more
doaj +2 more sources
Nucleotide analogue inhibitors of purine nucleoside phosphorylase.
Journal of Biological Chemistry, 1990 The diphosphate of the antiherpetic agent acyclovir [9-[(2-hydroxyethoxy)methyl]guanine] has been shown to inhibit purine nucleoside phosphorylase with unique potency (Tuttle, J. V., and Krenitsky, T. A. (1984) J. Biol. Chem. 259, 4065-4069). A major factor contributing to the superior inhibition by this diphosphate over the corresponding mono- and ...
Thomas A. Krenitsky +5 more
openalex +4 more sources
Purine nucleoside phosphorylase targeted by annexin v to breast cancer vasculature for enzyme prodrug therapy. [PDF]
PLoS ONE, 2013 BACKGROUND AND PURPOSE: The targeting of therapeutics is a promising approach for the development of new cancer treatments that seek to reduce the devastating side effects caused by the systemic administration of current drugs.
John J Krais +2 more
doaj +2 more sources
A trimeric structure for mammalian purine nucleoside phosphorylase [PDF]
FEBS Letters, 1973 Yvonne H. Edwards +2 more
openalex +5 more sources