Purine nucleoside phosphorylase controls nicotinamide riboside metabolism in mammalian cells [PDF]
J Biol Chem, 2022 A. Kropotov +13 more
semanticscholar +2 more sources
Radical Dehalogenation and Purine Nucleoside Phosphorylase E. coli: How Does an Admixture of 2′,3′-Anhydroinosine Hinder 2-fluoro-cordycepin Synthesis [PDF]
Biomolecules, 2021 During the preparative synthesis of 2-fluorocordycepin from 2-fluoroadenosine and 3′-deoxyinosine catalyzed by E. coli purine nucleoside phosphorylase, a slowdown of the reaction and decrease of yield down to 5% were encountered.
Alexey L. Kayushin +12 more
doaj +2 more sources
Inverse enzyme isotope effects in human purine nucleoside phosphorylase with heavy asparagine labels [PDF]
Proc Natl Acad Sci U S A, 2018 Significance Enzymes achieve catalytic efficiency by optimizing contacts between reactants and catalytic site amino acids. The transition state forms rarely, with a lifetime of a few femtoseconds.
R. Harijan +4 more
semanticscholar +2 more sources
Propolis Exerts an Anti-Inflammatory Effect on PMA-Differentiated THP-1 Cells via Inhibition of Purine Nucleoside Phosphorylase [PDF]
Metabolites, 2019 Previous research has shown that propolis has immunomodulatory activity. Propolis extracts from different geographic origins were assessed for their anti-inflammatory activities by investigating their ability to alter the production of tumour necrosis ...
Abdulmalik M. Alqarni +6 more
semanticscholar +2 more sources
Crystallographic snapshots of ligand binding to hexameric purine nucleoside phosphorylase and kinetic studies give insight into the mechanism of catalysis [PDF]
Sci Rep, 2018 Purine nucleoside phosphorylase (PNP) catalyses the cleavage of the glycosidic bond of purine nucleosides using phosphate instead of water as a second substrate.
Z. Štefanić +5 more
semanticscholar +2 more sources
Immunodeficiency, motor delay, and hypouricemia caused by a novel mutation of purine nucleoside phosphorylase gene in an Indian infant [PDF]
Annals of Indian Academy of Neurology, 2019 We describe an 11-month-old boy who presented with recurrent respiratory infections from 6 months of age. His elder sister died at 10 months with severe septicemia and meningitis. The boy had a mild motor delay.
Nikit Shah +5 more
doaj +2 more sources
Purine Nucleoside Phosphorylase (PNP) as a Biomarker and Therapeutic Target in Muscle-Invasive Bladder Cancer [PDF]
Clinical Medicine Insights: OncologyBackground: This study investigates the potential of purine nucleoside phosphorylase (PNP) as a biomarker and therapeutic target in muscle-invasive bladder cancer (MIBC).
Yanfei Chen +5 more
doaj +2 more sources
Molecules, 2023 To explore the anti-hyperuricemia components in sunflower (Helianthus annuus L.) calathide extract (SCE), we identified abietic acid (AA) via liquid chromatography–mass spectrometry and found an excellent inhibitor of xanthine oxidase (IC50 = 10.60 µM ...
Huining Dai +5 more
doaj +1 more source
Purine nucleoside phosphorylase [PDF]
Biomeditsinskaya Khimiya, 2013 Purine nucleoside phosphorylase (PNP) is one of the most important enzymes of the purine metabolism, wich promotes the recycling of purine bases. Nowadays is the actual to search for effective inhibitors of this enzyme which is necessary for creation T-cell immunodeficient status of the organism in the organs and tissues transplantation, and ...
L G, Pogosian, Zh I, Akopian
openaire +2 more sources
Genetic resistance to purine nucleoside phosphorylase inhibition in Plasmodium falciparum [PDF]
Proc Natl Acad Sci U S A, 2018 R. G. Ducati +6 more
semanticscholar +2 more sources