Results 51 to 60 of about 19,457 (231)

Polymorphisme de la purine nucléoside phosphorylase érythrocytaire bovine

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1984
La distribution de variants électrophorétiques de la purine nucléoside phosphorylase (N.P.) contrôlée par deux allèles NP.H et NP.L a été étudiée sur des hémolysats bovins appartenant à des populations autochtones de zébus ou de taurins (race Baoulé) et ...
R. Quéval, L. Bambara
doaj   +1 more source

The First Purine Nucleoside Phosphorylase Deficiency Patient Resembling IgA Deficiency and a Review of the Literature

Immunological Investigations, 2019
Purine nucleoside phosphorylase (PNP) deficiency is a rare autosomal recessive primary immunodeficiency disorder characterized by decreased numbers of T-cells, variable B-cell abnormalities, decreased amount of serum uric acid and PNP enzyme activity ...
Saba Fekrvand, R. Yazdani, Hassan Abolhassani, J. Ghaffari, A. Aghamohammadi   +4 more
semanticscholar   +1 more source

Design and Synthesis of New Modified Flexible Purine Bases as Potential Inhibitors of Human PNP

Molecules, 2023
The great interest in studying the structure of human purine nucleoside phosphorylase (hPNP) and the continued search for effective inhibitors is due to the importance of the enzyme as a target in the therapy of T-cell proliferative diseases. In addition,
Anastasia Khandazhinskaya, Ilja Fateev, Barbara Eletskaya, Anna Maslova, Irina Konstantinova, Katherine Seley-Radtke, Sergey Kochetkov, Elena Matyugina   +7 more
doaj   +1 more source

Intracellular Delivery of Human Purine Nucleoside Phosphorylase by Engineered Diphtheria Toxin Rescues Function in Target Cells.

Molecular Pharmaceutics, 2018
Despite a wealth of potential applications inside target cells, protein-based therapeutics are largely limited to extracellular targets due to the inability of proteins to readily cross biological membranes and enter the cytosol.
Minyoung Park, Xiaobai Xu, W. Min, S. Sugiman-Marangos, Greg L. Beilhartz, Jarrett J. Adams, S. Sidhu, E. Grunebaum, R. Melnyk   +8 more
semanticscholar   +1 more source

Some inhibitors of purine nucleoside phosphorylase [PDF]

Biomeditsinskaya Khimiya, 2011
Purine nucleoside phosphorylase (PNP) catalyzes reversible phosphorolysis of purine deoxy- and ribonucleosides with formation (d)Rib-1-P and corresponding bases. PNP plays a leading role in the cell metabolism of nucleosides and nucleotides, as well as in maintaining the immune status of an organism.
L G, Pogosian, L S, Nersesova, M G, Gazariants, Z S, Mkrtchian, Zh I, Akopian   +4 more
openaire   +2 more sources

Investigating the Role of Guanosine on Human Neuroblastoma Cell Differentiation and the Underlying Molecular Mechanisms

Frontiers in Pharmacology, 2021
Neuroblastoma arises from neural crest cell precursors failing to complete the process of differentiation. Thus, agents helping tumor cells to differentiate into normal cells can represent a valid therapeutic strategy.
Natale Belluardo, Giuseppa Mudò, Valentina Di Liberto, Monica Frinchi, Daniele F. Condorelli, Ugo Traversa, Francisco Ciruela, Francisco Ciruela, Renata Ciccarelli, Renata Ciccarelli, Patrizia Di Iorio, Patrizia Di Iorio, Patricia Giuliani, Patricia Giuliani   +13 more
doaj   +1 more source

Engineering a Bifunctional Fusion Purine/Pyrimidine Nucleoside Phosphorylase for the Production of Nucleoside Analogs

Biomolecules
Nucleoside phosphorylases (NPs) are pivotal enzymes in the salvage pathway, catalyzing the reversible phosphorolysis of nucleosides to produce nucleobases and α-D-ribose 1-phosphate.
Daniel Hormigo, Jon Del Arco, Javier Acosta, Maximilian J. L. J. Fürst, Jesús Fernández-Lucas   +4 more
doaj   +1 more source

Propolis Exerts an Anti-Inflammatory Effect on PMA-Differentiated THP-1 Cells via Inhibition of Purine Nucleoside Phosphorylase

Metabolites, 2019
Previous research has shown that propolis has immunomodulatory activity. Propolis extracts from different geographic origins were assessed for their anti-inflammatory activities by investigating their ability to alter the production of tumour necrosis ...
Abdulmalik M. Alqarni, K. Niwasabutra, M. Sahlan, H. Fearnley, James Fearnley, V. Ferro, D. Watson   +6 more
semanticscholar   +1 more source

Sustainable Flow‐Synthesis of (Bulky) Nucleoside Drugs by a Novel and Highly Stable Nucleoside Phosphorylase Immobilized on Reusable Supports

ChemSusChem, 2021
The continuous synthesis of valuable nucleoside drugs was achieved in up to 99 % conversion by using a novel halotolerant purine nucleoside phosphorylase from Halomonas elongata (HePNP).
A. I. Benítez-Mateos, F. Paradisi
semanticscholar   +1 more source

A Rapid Colorimetric Method for Determining Calcium, Inorganic Phosphorus, and Zinc in Human Milk Using Clinical Laboratory Reagents

Journal of Clinical Laboratory Analysis, Volume 40, Issue 2, January 2026.
We evaluated a colorimetric assay using clinical reagents for determining Ca, IP, and Zn in human milk. Significant correlations were observed between Ca, IP, and Zn levels determined by colorimetric assay and Ca, total P, and Zn levels determined by ICP‐AES.
Miori Tanaka, Misaki Mochida, Midori Date, Katsumi Mizuno   +3 more
wiley   +1 more source