Results 131 to 140 of about 144,015 (298)
, 1982 Purine cyclic nucleotides and epidermal growth factor (EGF) synergistically stimulate neonatal rat hepatocytes growth in primary cultures.
ARMATO, Ubaldo
core +1 more source
Quantitative aspects of intramolecular interactions in ternary complexes of purine nucleotides and amino acids [PDF]
, 1998 769-774Interaction Of bivalent metal ions (CO2+,Ni2+, Cu2+,Zn2+) with purine nucleotides (5' - guanosinemono-phosphate and 5' - inosinemonophonsphate) and amino acids (alanine, phenylalanine and tryptophan) in I: I and I: I: 1 ratios has been ...
Venkatadri, E, Reddy, P Rabindra
core
The potential for biased signalling in the P2Y receptor family of GPCRs
British Journal of Pharmacology, EarlyView.The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk +2 more
wiley +1 more source
Estudo do mecanismo neuroprotetor da guanosina em fatias de hipocampo de ratos submetidas à privação de glicose e oxigêncio [PDF]
, 2007 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas.
Nogueira, Scheyla Paula Bollmann Oleskovicz
core
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
O efeito trófico dos derivados da guanina em culturas de astrócitos e neurônios cerebelares [PDF]
, 2006 Dissertação (mestrado) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.Neste estudo foi avaliado o efeito de GMP ou Guanosina em três diferentes situações: o efeito trófico sobre ...
Decker, Helena
core
British Journal of Pharmacology, EarlyView.Immune checkpoint inhibitor (ICI)‐associated myocarditis has emerged as a severe and clinically complex immune‐related toxicity that poses significant challenges for therapeutic decision‐making in routine cardio‐oncological care. High‐dose corticosteroids remain the first‐line therapy, yet their timing, dosage and tapering require careful clinical ...
Raluca I. Mincu +10 more
wiley +1 more source
IMPDH2 filaments protect from neurodegeneration in AMPD2 deficiency
EMBO ReportsMetabolic dysregulation is one of the most common causes of pediatric neurodegenerative disorders. However, how the disruption of ubiquitous and essential metabolic pathways predominantly affect neural tissue remains unclear.
Marco Flores-Mendez +7 more
doaj +1 more source
Peripheral targets for neuropathic pain
British Journal of Pharmacology, EarlyView.Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour +3 more
wiley +1 more source
Cancer Science, EarlyView.Using both conventional observational and Mendelian randomization (MR) analyses in the same Japanese community‐dwelling population, the evidence consistently supported an inverse association between the serum uric acid level and lung cancer risk. ABSTRACT We examined the association between serum uric acid (UA) levels and cancer incidence through a ...
Takashi Matsunaga +26 more
wiley +1 more source