Results 151 to 160 of about 144,015 (298)

Established and Emerging Biomarkers to Characterize Persons at Risk for Obesity—Paving the Way for Targeted Clinical Intervention Trials—A Comprehensive Position Paper

Obesity Reviews, EarlyView.
ABSTRACT Despite all efforts, obesity remains a major health concern worldwide, with continuously increasing rates, affecting approx. 14% of the total world population, being as high as 43% in some countries. As obesity is related to numerous comorbidities, including type 2 diabetes, cardiovascular diseases, and some types of cancer, the consequences ...
Farhad Vahid, Victoria Stopa, Laurent Malisoux, Yvan Devaux, Elsa Lamy, Fernando Capela e Silva, Sarah Forberger, Tiziana de Magistris, Antoni Sureda, Margalida Monserrat‐Mesquida, Maria Pérez‐Jiménez, Rajini Nagrani, Maria Giovanna Onorati, Michele Filippo Fontefrancesco, Jonathan Turner, Mahesh S. Desai, Josep Tur, Cristina Bouzas, Gino Gabriel Bonetti, Oliver Riedel, Gitte Ravn‐Haren, Rikke Andersen, Torsten Bohn   +22 more
wiley   +1 more source

Purine Nucleotide Cycles and Their Metabolic Role

Journal of Biological Chemistry, 1960
B, MAGASANIK, D, KARIBIAN
openaire   +2 more sources

2,6-Bis-Triazolyl Purine Deoxyribo-Nucleosides and Their Reactions with N-Nucleophiles

New 2,6-bis-triazolyl derivatives of purine deoxyribo-nucleosides have been synthesized and their reactions with piperidine and pyrrolidine have been ...
Cīrule, Dace, Bizdēna, Ērika, Novosjolova, Irina, Ozols, Kristers   +3 more
core  

A Post–NGP Mitsuokella jalaludinii as a Therapeutic Candidate for Gout

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Schematic summary of the therapeutic mechanisms and evaluation of the post–NGP strain M. jalaludinii PMC73 for gout. PMC73 demonstrated uric acid–lowering efficacy through purine catabolism and hypoxanthine utilization, along with intracellular uric acid reduction in macrophages.
Mohammed Solayman Hossain, Sukyung Kim, Md Tareque Aziz, Izaz Ahmed, Md Sarower Hossen Shuvo, Hyewon Yang, Yunjeong Jang, Minseo Kim, Seohyeon Jang, Yusol Kim, Soeun Oh, Yunseo Nam, Hoonhee Seo, Ho‐Yeon Song   +13 more
wiley   +1 more source

Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
This review systematically covers three core dimensions of brown adipose tissue (BAT): multilayered regulatory mechanisms governing brown adipocyte differentiation and phenotypic identity, physiological functions and signaling pathways in mediating thermogenesis and systemic metabolic crosstalk between BAT and multiple organs, and emerging clinical in ...
Xiaoli Deng, Yuanyuan Shen, Ying Sun, Lu Lu, Chongkui Sun   +4 more
wiley   +1 more source

De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence. [PDF]

Microbiologyopen
Joshi R, McEwan AG, Kappler U.
europepmc   +1 more source

Synthesis and Properties of Triazolyl Purine Nucleosides

A novel class of bis-triazolyl purine nucleosides was obtained and triazolyl moiety at C(6) of the purine base undergoes a facile nucleophilic heteroaromatic substitution with N- and S-nucleophiles.
Novosjolova, Irina
core  

Integrating the MARTINI2 coarse‐grained force field into HADDOCK3 for faster modeling of large biomolecular complexes

Protein Science, Volume 35, Issue 10, October 2026.
Abstract The integration of coarse‐grained (CG) approaches into docking workflows offers a powerful strategy for modeling large biomolecular assemblies with reduced computational costs. We present here the implementation of the MARTINI2 CG force field into the HADDOCK3 integrative modeling platform.
Raphaelle Versini, Victor Reys, Anna Kravchenko, Rodrigo V. Honorato, Alexandre M. J. J. Bonvin   +4 more
wiley   +1 more source

Nucleotide Metabolism in Health and Disease. [PDF]

MedComm (2020)
Zhao X, Zeng Y, Xu Y, Rao S, Khouchani M, Soummane H, Li J, Liu R.   +7 more
europepmc   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1686-1701, October 2026.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source