Results 161 to 170 of about 144,015 (298)

STING agonist profiling by nucleotide library defines structural determinants of cyclic dinucleotide recognition. [PDF]

iScience
Bekere I, Hubarzhevska Y, Egender SV, Quoika PK, Öllinger R, Schrimpf MR, Rad R, Zacharias M, de Oliveira Mann CC.   +8 more
europepmc   +1 more source

Quantitative analysis of purine nucleotides indicates that purinosomes increase de novo purine biosynthesis. [PDF]

J Biol Chem, 2015
Zhao H, Chiaro CR, Zhang L, Smith PB, Chan CY, Pedley AM, Pugh RJ, French JB, Patterson AD, Benkovic SJ.   +9 more
europepmc   +1 more source

Transcriptomic and Metabolomic Profiling Identifies a Core Gene–Metabolite Axis Driving African Swine Fever Virus Replication in the Soft Tick Ornithodoros lahorensis

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Transcriptomic and metabolomic profiling of Ornithodoros lahorensis during African swine fever virus (ASFV) infection reveals that ASFV rewires host purine/pyrimidine metabolism, lipid metabolism, and energy metabolism. A core gene‐metabolite regulatory axis consisting of 12 key genes and 8 signature metabolites is identified to support viral genome ...
Jin Luo, Kaifei Guo, Fangyu Xiao, Ruoqi Wang, Junhui Guo, Qiaoyun Ren, Shuaiyang Zhao, Muhammad Kashif Obaid, Guiquan Guan, Hong Yin   +9 more
wiley   +1 more source

Substrate Specificity of B12-Depedent Ribonucleotide Reductases: Biotechnology and Metabolic Implications. [PDF]

Chembiochem
Eltoukhy L, Loderer C.
europepmc   +1 more source

Structure‐Guided Optimization of PDE9A Inhibitors Tackling Neuroinflammation: A Combined Computational and In Vitro Study

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
Computational studies allowed the identification of a PDE9A inhibitor. A novel HPLC‐based assay was developed and optimized to measure enzyme function to assess PDE9A inhibition. Furthermore, in vitro tests supported the activity of the compound against neuroinflammation. Oxidative stress and inflammation are key players in central nervous system (CNS)
Giovanni Ribaudo, Elisa Landucci, Margrate Anyanwu, Costanza Mazzantini, Matteo Giannangeli, Stefano Rosa, Francesca Mainolfi, Maura Calvani, Maurizio Memo, Domenico E. Pellegrini‐Giampietro, Alessandra Gianoncelli   +10 more
wiley   +1 more source

A Structural Context for the Mechanisms of Uncoupling Protein 1 in Brown Fat Thermogenesis. [PDF]

Acta Physiol (Oxf)
Cavalieri R, Dela Rosa MAS, Cotrim CA, Copeman D, Aris M, Eke C, Staggs-Sandy H, Crichton PG.   +7 more
europepmc   +1 more source

PURINE INCORPORATION INTO PENTOSE NUCLEOTIDES OF THE RAT

Journal of Biological Chemistry, 1951
D H, MARRIAN, V L, SPICER, M E, BALIS, G B, BROWN   +3 more
openaire   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, Volume 600, Issue 17, Page 2579-2614, September 2026.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

R3DCID: circular interaction diagrams for RNA and DNA 3D structures of all sizes. [PDF]

RNA
Fonga PN, Abubaker SM, Thaman J, Zirbel CL.   +3 more
europepmc   +1 more source

Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach

Advanced Science, Volume 13, Issue 50, 7 September 2026.
The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen, Jiayi Liang, Yujia Wu, Jianan Xu, Yi Liu, Wenguang Wang, Xinhang Jiang, Benjie Gao, Yueyue Wang, Hui Jiang   +9 more
wiley   +1 more source