Results 171 to 180 of about 144,015 (298)

Extended sequence context shapes mutational bias in <i>Escherichia coli</i>. [PDF]

Proc Natl Acad Sci U S A
Jago MJ, Green R, Czernuszka MR, Denisov S, Krašovec R, Knight CG, Lagator M.   +6 more
europepmc   +1 more source

Light‐Activated Ruthenium Nanoclusters Reprogram the Metabolic‐Quorum Sensing Axis for Precision Periodontitis Therapy

Advanced Science, Volume 13, Issue 52, 18 September 2026.
Under 660 nm visible light, Ru NCs efficiently photocatalyze nitrate‐to‐ammonium conversion and modulate oral nitrogen metabolism. They precisely perturb Veillonella parvula, block its key support to Porphyromonas gingivalis, and exert an “inhibiting without killing” antivirulence effect.
Jing Zhou, Xiaolin Sun, Chengyu Liu, Yujia Shi, Meiqi Li, Meng Bo, Jingjie Zhai, Chunyan Li, Zhennan Wu, Xue Bai, Lin Wang   +10 more
wiley   +1 more source

Translation initiation by the Kozak mRNA sequence is based on a conformational readout on the ribosome. [PDF]

Nat Commun
von Loeffelholz O, Barchet C, Holvec S, Abou Ramadan A, Protuc C, Maglott-Roth A, de Silva SNT, Hazemann I, Klaholz BP.   +8 more
europepmc   +1 more source

ENT1 inhibition links oligodendrocyte lipid metabolism to connectivity in tauopathy

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Metabolic dysfunction, altered adenosine signaling, and white matter abnormalities are implicated in tauopathies, but their relationship to network disconnection remains unclear. Myelinating oligodendrocytes may represent a metabolically vulnerable hub linking these processes to circuit dysfunction.
Ching‐Pang Chang, Ching‐Wen Chang, Ching‐Wen Wu, Jian Jing Siew, David Blum, Lee‐Way Jin, You‐Yin Chen, Yijuang Chern   +7 more
wiley   +1 more source

Inosine monophosphate dehydrogenases are key players for functional development in Arabidopsis. [PDF]

Plant J
Dörfer E, Sadeghi Z, Frick V, Ebel K, Heide A, Niehoff T, Zehner S, Fischer L, Witte CP, Herde M, Möhlmann T.   +10 more
europepmc   +1 more source

Perinatal lead (Pb) exposure and alterations to amyloid beta and metabolic profiles in the brain

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Developmental neurotoxicant exposures (e.g., lead [Pb]) are suspected contributors to dementia. Dementia is characterized by amyloid beta (Aβ) plaques and dysregulated metabolism. To better understand the relationship between environment and dementia risk, we assessed the impact of perinatal Pb exposure on dementia‐related ...
Rachel K. Morgan, Evelyn K. Matei, Junru Pan, Tomoko Ishikawa, Katelyn M. Polemi, Ingrid Bergin, Sean P. Ferris, Hao Wang, Dana C. Dolinoy, Kelly M. Bakulski, Justin A. Colacino   +10 more
wiley   +1 more source

Primer- and template-independent RNA polymerization by terminal nucleotidyltransferase TENT4B. [PDF]

Nucleic Acids Res
Nagpal N, Tai AK, Fong YW, Agarwal S.
europepmc   +1 more source

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, Volume 78, Issue 9, Page 1989-1999, September 2026.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

Japanese encephalitis virus hijacks the host purine biosynthetic network to promote viral replication in neurons. [PDF]

PLoS Pathog
Gu J, Fan C, Xiang S, Yang L, Liu J, Si Y, Zhu B, Sun Y, Ding C, Cao S, Ye J.   +10 more
europepmc   +1 more source

Tissue‐Specific and Spatially Dependent Metabolic Signatures Perturbed by Injury in Male and Female Mice

Arthritis &Rheumatology, Volume 78, Issue 9, Page 1850-1862, September 2026.
Objective Osteoarthritis, the leading cause of disability worldwide, disproportionately affects women, yet sex remains an overlooked determinant. This disparity stems from sex‐specific differences in injury susceptibility—a major risk factor for disease.
Hope D. Welhaven, Avery H. Welfley, Priyanka P. Brahmachary, Mark Greenwood, Donald F. Smith, Brian Bothner, Ronald K. June   +6 more
wiley   +1 more source