Results 171 to 180 of about 78,151 (289)

Structural and Functional Analyses of <i>Trypanosoma brucei</i> Nucleoside Diphosphate Kinase. [PDF]

ACS Omega
Makori P, Boeckman MP, David HS, Payne F, Gatling M, Greer C, Hayes D, Jefferson A, Maxwell M, Smith C, Watson J, Williams L, Barkley J, Pepper C, Zininga T, Subramanian S, Abramov A, Gardberg AS, Edwards TE, Staker BL, Stewart LJ, Myler PJ, Asojo OA, Jeje O, Fanucchi S, Achilonu I, Smith CL, Chakafana G.   +27 more
europepmc   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, Volume 600, Issue 9, Page 1373-1385, May 2026.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT. [PDF]

Science
Wu Z, Nguyen PT, Sondhi V, Yao RW, Lu Z, Dai T, Chiang JC, Cai F, Williams IM, Blatt EB, Shang Z, Cai L, Zhang J, Moore MD, Alshamleh I, Li X, Ogu T, Zacharias LG, Winston R, Patricio JS, Johnson X, Chen WM, Cong Q, Mathews TP, Zhang Y, Zhang L, DeBerardinis RJ.   +26 more
europepmc   +1 more source

Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Adenosine, as a key metabolic and neurotransmitter in the brain, has become an important therapeutic target for improving the efficacy of immunotherapy for stroke. However, gaps in knowledge about its metabolic pathways have become a key factor limiting its clinical translation.
Shu Zhu, Shanshan Zhong, Xiaoru Lin, Chuansheng Zhao, Yugang Li   +4 more
wiley   +1 more source

Conjugated 2′‐Fucosyllactose–Potato Protein Hydrolysate as Novel Prebiotics

Food Frontiers, Volume 7, Issue 3, May 2026.
This study introduces a novel protein‐containing prebiotic based on 2′‐FL‐PPH Maillard conjugates micelles that co‐deliver proteins and carbohydrates to the colon to selectively nourish colonic probiotics. These digestion‐resistant micelles enhanced Bifidobacteria, SCFAs, gut barrier integrity, and metabolic health more effectively than conventional ...
Stav Peled, May Cohen‐Hakmon, Ravit Edelman, Yechezkel Kashi, Yoav D. Livney   +4 more
wiley   +1 more source

NAD⁺ Enhancer Nicotinamide Riboside Alters Extracellular Purine Metabolism in Human Endothelial Cells. [PDF]

Int J Mol Sci
Harasim-Krawcewicz G, Mierzejewska P, Kawecka A, Frańczak MA, Król O, Presler M, Jędrzejewska A, Kutryb-Zając B, Smoleński RT, Słomińska E.   +9 more
europepmc   +1 more source

Camellia oleifera Seed Cake Extract Ameliorates Hyperuricemia and Renal Injury by Modulating Uric Acid Metabolism, Nrf2/Keap1 Pathway, and NLRP3 Inflammasome in Mice

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Protective mechanisms of Camellia oleifera seed cake extract (SCE) against hyperuricemia and renal injury via modulation of uric acid metabolism, Nrf2/Keap1 signaling, and NLRP3 inflammasome activation. ABSTRACT Camellia oleifera seed cake is a major byproduct of the oil industry, often underutilized despite its richness in bioactive compounds.
Liting Mai, Youliang Xie, Yingzhong Zhang, Chen Ni, Ying Xu, Lieqiang Xu, Guoshu Lin, Yinsi Lin, Ziren Su, Jing Wang, Mihong Ren   +10 more
wiley   +1 more source

Integrated transcriptomic and metabolomic analysis identifies C5NT1AL as a candidate gene influencing inosine monophosphate levels in chicken breast muscle. [PDF]

Poult Sci
Yang H, Liu L, Wang Y, Wang Y, Zhuang J, Cui H, Zhao G, Wen J.   +7 more
europepmc   +1 more source

Serum Uric Acid Levels and the Risk of Breast Cancer and Benign Breast Tumors: A Systematic Review and Meta‐Analysis

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Serum uric acid (SUA) has been implicated in various pathological conditions, yet its association with breast pathology remains controversial. This study aimed to investigate the association between SUA levels and breast cancer (BC) and benign breast tumors (BBT) risk through systematic review and meta‐analysis.
HaiXia Mo, WenFeng Liao, XinRi Chen, ManLing Li, MengYing Wang, Yan Li   +5 more
wiley   +1 more source

Mycophenolate mofetil reduces the branching of microglial processes. [PDF]

Mol Brain
Teruya RI, Ueda K, Taketomi T, Yamamoto T, Yamashita N, Konno H, Tsuruta F.   +6 more
europepmc   +1 more source