Results 191 to 200 of about 78,151 (289)

Re‐Evaluating Hot Mitochondria: Too Slow to Cool

Acta Physiologica, Volume 242, Issue 5, May 2026.
ABSTRACT Aim Mito Thermo Yellow (MTY) is a mitochondrially targeted fluorophore that shows marked fluorescence quenching with increasing temperature, allowing for interrogating temperature dynamics in the mitochondria of live cells. Here we re‐evaluate published MTY fluorescence responses used to argue in favor of the ‘hot mitochondria’ concept; the ...
Jason R. Treberg, Ryan J. Mailloux
wiley   +1 more source

Investigating Polarity Effects in DNA Base Stacking. [PDF]

JACS Au
Abraham Punnoose J, Kam CS, Melfi T, Vangaveti S, Chen AA, Halvorsen K.   +5 more
europepmc   +1 more source

Small Cell Lung Cancer Establishes a Metabolic Autocrine Mechanism Through Active Extracellular ATP Transport

Cancer Science, Volume 117, Issue 5, Page 1333-1345, May 2026.
Small cell lung cancer (SCLC) actively exports ATP through PANX1 channels, triggering P2RX7‐mediated autocrine signaling and promoting tumor proliferation. Inhibition of PANX1 or P2RX7 disrupts this loop and suppresses tumor growth. ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignancy with a 5‐year survival rate of less than 7%.
Takeshi Tsuruda, Manabu Kodama, Keiichi I. Nakayama   +2 more
wiley   +1 more source

Structure of an initiation complex of mycobacterial helicase-nuclease AdnAB at a blunt double-strand break reveals local melting that engages the 3' tracking strand at the ratchet pawl of the helicase motor. [PDF]

Nucleic Acids Res
Warren GM, Jason de la Cruz M, Goldgur Y, Shuman S.   +3 more
europepmc   +1 more source

Oxidation of purine nucleotides by Triplet 3,3',4,4'-benzophenone tetracarboxylic acid in aqueous solution: pH-dependence. [PDF]

J Phys Chem A, 2014
Saprygina NN, Morozova OB, Abramova TV, Grampp G, Yurkovskaya AV.   +4 more
europepmc   +1 more source

Serum Metabolomics Study Reveals a Diagnostic Model for Lung Cancer Brain Metastasis

The Clinical Respiratory Journal, Volume 20, Issue 5, May 2026.
The overall workflow of noninvasive and efficient early diagnostic methods and key features of metabolic dysregulation associated with lung cancer brain metastasis, providing novel molecular insights into its pathogenesis and laying a foundation for future translational applications.
Hongxia Zhu, Yinuo Jin, Xin You, Qi Wang
wiley   +1 more source

Asymmetry of nucleotide substitutions in tRNAs indicates common descent of modern organisms from a thermophilic ancestor. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Titov II.
europepmc   +1 more source

Circulating Rhythmic Metabolites and Causal Risk of Type 2 Diabetes in Adults in the Canadian Longitudinal Study on Aging

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 4243-4252, May 2026.
ABSTRACT Aims Circadian regulation of metabolism is an important factor in metabolic health, yet the role of rhythmic metabolites in Type 2 diabetes development remains poorly understood. This study investigated associations between circulating rhythmic metabolites and incident Type 2 diabetes risk and evaluated causal relationships using two‐sample ...
Divya Joshi, Talha Rafiq, Marie Pigeyre, Renee de Mutsert, Femke Rutters, David J.T. Campbell, Jean‐Pierre Despres, Andre C. Carpentier, Joris Hoeks, Patrick Schrauwen, Parminder Raina   +10 more
wiley   +1 more source

Microcephaly-associated protein WDR62 supports purine metabolism by interacting with co-chaperone BAG2. [PDF]

EMBO J
Morris MJ, Yeap YY, Edwards JR, Chen C, Paolino A, Furness SGB, Millard SS, Pagan JK, Fenlon LR, Ng DCH.   +9 more
europepmc   +1 more source

Microbiome of Apical Intracanal and Extraradicular Biofilms From the Same Roots of Teeth With Persistent Apical Periodontitis: An Observational Study

International Endodontic Journal, Volume 59, Issue 5, Page 806-818, May 2026.
ABSTRACT Aim Bacterial biofilms around the apex are crucial in disease progression and persistence of apical periodontitis. While intracanal biofilms initiate infection, extraradicular biofilms contribute to treatment resistance and persistence. Thus, a comprehensive understanding of these biofilms may help elucidate mechanisms underlying persistent ...
Yoko Asahi, Nanako Kuriki, Motoki Okamoto, Daisuke Motooka, Shota Nakamura, Hazuki Maezono, Kittipit Klanliang, Tsuyoshi Shimaoka, Tetsuya Iida, Shigeyuki Ebisu, Yuichiro Noiri, Mikako Hayashi   +11 more
wiley   +1 more source