Results 211 to 220 of about 47,484 (302)

Transition–Transversion Bias at the CYTB Gene Level in the Order Cypriniformes (Actinopterygii) as Evidence for the Influence of Metabolic Rate on Molecular Evolutionary Rate

Ecology and Evolution, Volume 16, Issue 7, July 2026.
Families and subfamilies inhabiting temperate regions exhibit increasing transition frequencies and decreasing transversion frequencies with increasing genetic divergence, resulting in a pronounced transition–transversion bias. In contrast, tropical taxa show the opposite pattern, with elevated transversion frequencies and a markedly weaker bias.
S. V. Mezhzherin, S. Y. Morozov‐Leonov
wiley   +1 more source

De novo nucleotide biosynthesis and its dynamic regulation are crucial for systemic infection by extraintestinal Escherichia coli. [PDF]

PLoS Pathog
Zhang C, Yang Y, Wang S, Liu Y, Zhao X, Yin F, Hu Y, Xue Y, Bu Z, Li S, Tan C, Zhou R, Huang Q.   +12 more
europepmc   +1 more source

Neuroprotective Effects of Biosynthetic d‐Calcium Pantothenate and Cyanocobalamin Against MPTP‐Induced Parkinsonism via Microbiota Modulation, Metabolic Homeostasis Restoration, and Endoplasmic Reticulum Stress Inhibition

Food Frontiers, Volume 7, Issue 4, July 2026.
Biosynthetic D‐calcium pantothenate and cyanocobalamin alleviate MPTP‐induced Parkinsonism in mice by modulating gut microbiota, restoring metabolic homeostasis, and inhibiting Endoplasmic Reticulum Stress. ABSTRACT Vitamin B5 (VB5) and Vitamin B12 (VB12) are essential micronutrients widely distributed in functional foods, yet their neuroprotective ...
Yaru Chen, Shaohui Zhu, Yajie Ruan, Kaiqi Zheng, Jing Wang, Qianqian Guan, Tao Xiong   +6 more
wiley   +1 more source

Effect of Chitooligosaccharides‐Combination Fortified Noodles Intervention on Visceral Adiposity and Serum Metabolites in a High‐Risk Occupational Cohort of Young Seafarers

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
In a 4‐week self‐controlled trial of 73 young seafarers, consumption of chitooligosaccharides‐combination fortified noodles every other day significantly reduced visceral fat area, waist circumference, serum leptin, and LDL‐C, and elevated skeletal muscle index, without altering body weight.
Zhongbo Bian, Jiaming Wang, Yi Lu, YanYing Yao, Xiangru Feng, Xinjie Zhou, Xiao guo Ji, Juan Li   +7 more
wiley   +1 more source

Drug-induced hyperuricemia: multi-pathway regulation, causative drugs, and individualized management strategies. [PDF]

Front Pharmacol
Xiong B, Duan C, Xu S, Xu S, Yang C, He D, Luo C.   +6 more
europepmc   +1 more source

Zeaxanthin Mitigates Hydroxychloroquine‐Induced Retinal Toxicity and Metabolic Reprogramming in ARPE‐19 Cells

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 7, July 2026.
HCQ exposure disrupts lysosomal acidification, increases ROS production, impairs mitochondrial function, and induces metabolic reprogramming in ARPE‐19 cells, resulting in increased necrosis and reduced cell viability. ZEA treatment significantly reduced oxidative stress, stabilized mitochondrial membrane potential, improved metabolic homeostasis, and ...
Münire Berna Asal Altıparmak, Emine Merve Yıldırım, Ozan Kaplan, Emine Koç, Açelya Erikçi, Mustafa Çelebier, Tuba Tüylü Küçükkılınç, Gülberk Uçar   +7 more
wiley   +1 more source

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT. [PDF]

Science
Wu Z, Nguyen PT, Sondhi V, Yao RW, Lu Z, Dai T, Chiang JC, Cai F, Williams IM, Blatt EB, Shang Z, Cai L, Zhang J, Moore MD, Alshamleh I, Li X, Ogu T, Zacharias LG, Winston R, Patricio JS, Johnson X, Chen WM, Cong Q, Mathews TP, Zhang Y, Zhang L, DeBerardinis RJ.   +26 more
europepmc   +1 more source

First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT This guideline summarizes diagnostic and therapeutic approaches based on a systematic literature review and evidence evaluation using the GRADE methodology. Given the limited high‐quality data, expert consensus was additionally obtained through a modified Delphi process.
Giorgia Olivieri, Andrea Bordugo, Birute Burnyte, Alessandro Costetti, Maria‐Luz Couce, Luisa Diogo, Francois Feillet, D. Sean Froese, Benedetta Greco, Jean‐Louis Gueant, Luciana Hannibal, Friederike Hörster, Viktor Kožich, Giancarlo La Marca, Irini Manoli, Fanny Mochel, Lorenzo Orazi, Belén Pérez, Manuel Schiff, Bernd C. Schwahn, Ida Schwartz, Karolina M. Stepien, Jolanta Sykut‐Cegielska, Trine Tangeraas, Rolf H. Zetterström, Carlo Dionisi‐Vici, Martina Huemer   +26 more
wiley   +1 more source

NAD⁺ Enhancer Nicotinamide Riboside Alters Extracellular Purine Metabolism in Human Endothelial Cells. [PDF]

Int J Mol Sci
Harasim-Krawcewicz G, Mierzejewska P, Kawecka A, Frańczak MA, Król O, Presler M, Jędrzejewska A, Kutryb-Zając B, Smoleński RT, Słomińska E.   +9 more
europepmc   +1 more source

An Overview of Pterin Analysis in Biological Samples: From Occurrence and Properties to Sample Pretreatment Combined With Hyphenated Separation Techniques

Journal of Separation Science, Volume 49, Issue 7, July 2026.
ABSTRACT Pterins are a structurally diverse group of biologically active compounds within the pteridine family, with key roles in pigmentation, redox metabolism, light sensing, and cellular signaling across a wide range of organisms. Their quantification in biological samples is analytically demanding due to their high polarity, chemical instability ...
Jindřich Brejcha, Zuzana Bosakova
wiley   +1 more source