Results 241 to 250 of about 47,484 (302)

Profiling Nucleotide Signalling Pathways and STING Agonist Activity with a Nucleotide Library

Bekere I, Öllinger R, Schrimpf MR, Rad R, de Oliveira Mann CC.   +4 more
europepmc   +1 more source

Inhibition of human poly(A)-specific ribonuclease (PARN) by purine nucleotides: kinetic analysis [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2009
Poly(A)-specific ribonuclease (PARN) is a cap-interacting and poly(A)-specific 3'-exoribonuclease that efficiently degrades mRNA poly(A) tails. Based on the enzyme's preference for its natural substrates, we examined the role of purine nucleotides as ...
Nikolaos Balatsos, Constantinos Stathopoulos, Dimitrios Anastasakis   +2 more
exaly   +2 more sources

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Purine nucleotide catabolism in placenta

American Journal of Obstetrics and Gynecology, 1964
Abstract Soluble extracts were utilized to delineate the catabolic pathways of purine 2′,3′- and 5′-ribonucleoside monophosphates in human placenta and to measure the relative activities of the enzymes involved. Derivatives of adenine and hypoxanthine are converted to hypoxanthine, and derivatives of guanine are converted to xanthine.
T T, HAYASHI, R C, BALDRIDGE, P S, OLMSTED, D L, KIMMEL   +3 more
openaire   +2 more sources

Alterations in purine nucleotide pyrophosphorylases and resistance to purine analogues

Biochimica et Biophysica Acta, 1961
Abstract Resistance to purine analogues in mutants isolated from Salmonella typhimurium , strain LT-2 , resulted in the loss of specific purine nucleotide pyrophosphorylases. Thus, mutants resistant to 2,6-diaminopurine, 6-mercaptopurine, and 8-azaguanine lacked adenylic, inosinic and guanylic pyrophosphorylases, respectively. The mutants resistant
G P, KALLE, J S, GOTS
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Thermodynamics of the purine nucleotide cycle

Biophysical Chemistry, 2006
Since the standard Gibbs energies of formation are known for all the species in the purine nucleotide cycle at 298.15 K, the functions of pH and ionic strength that yield the standard transformed Gibbs energies of formation of the ten reactants can be calculated.
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Purine Nucleotide Catabolism in Rat Liver

2006
The higher specific radioactivity of ALL in comparison to UA, which are observed after administration of labelled precursors, changed when, oxonic acid and allopurinol, inhibitors of UA and ALL formation were administrated. To interpret these results, it is worth while to recall that nucleotide metabolism can be represented as a complex sequence ...
Marinello E., Pagani R., Arezzini L., Porcelli B., Cinci G., Terzuoli L.   +5 more
openaire   +4 more sources

Purine nucleotide cyclases in the malaria parasite

Trends in Parasitology, 2004
Cells use a variety of signal transduction pathways to coordinate their responses to changes in both the extracellular and intracellular environment. Activation of these pathways is often receptor mediated, resulting in the synthesis of second messenger molecules such as cAMP and cGMP.
David A, Baker, John M, Kelly
openaire   +2 more sources