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De Novo Purine Nucleotide Biosynthesis

1992
This chapter reviews current understanding of de novo purine nucleotide synthesis in Bacillus subtilis,with emphasis on recent developments in understanding gene organization and regulation and on the distinctive structural features of two enzymes of the pathway.
H, Zalkin, J E, Dixon
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Purine nucleotides as regulators of vessel tone

Biochemical Society Transactions, 1988
5‘-isobutylthioadenosine, but it was inhibited by 10 mMp-nitrophenylphsphate to 50 k 11% ( n = 6). The inhibition of the pigeon ventricle AMPase by other nucleoside monophosphates (with specificity for the base moeity), but not by ribose phosphate or B-glycerophosphate, indicates the presence of a 5’-nucleotidase.
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Purine nucleotides.

Advances in biochemical psychopharmacology, 1977
The existence of nonadrenergic, noncholinergic nerve components in the autonomic nervous system is now well established. They are strongly represented in the gastrointestinal tract of all vertebrates and have been identified in a variety of other organs, including lung, trachea, bladder, esophagus, eye, seminal vesicles, and possibly parts of the ...
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Degradation of Purine Nucleotides

1978
Purine nucleotides have a vital role in metabolism. Therefore, the maintenance of a constant nucleotide composition of the cell is essential for normal function. Purine nucleotides are synthesized by purine biosynthesis de novo, by salvage pathways and nucleoside kinases, and by degradation of nucleic acids.
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Purine Nucleotide Interconversions

1978
The various reactions of purine ribonucleotide synthesis result in the formation of adenylate, inosinate, and guanylate; xanthylate may also be formed, but this seems to be a quantitatively minor process in most mammalian cells. These purine ribonucleoside monophosphates can be metabolized in several different ways; these processes can in general be ...
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Purine Nucleotide Content in the Leukocytes of Leukemia Patients

1995
Purine nucleotides play an important role in cell life: they are precursors of RNA and DNA, and act as coenzymes and condensers of energy. The evaluation of their metabolism under physiological and pathological conditions is therefore of great interest.
Carlucci F.   +8 more
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Patterns of purine nucleotides in fish erythrocytes

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1979
1. The purine nucleotides were determined in the whole blood of 9 fresh water teleosts and 2 marine selachians. 2. GTP and ATP accounted for 88-99% of the total erythrocytes purines. 3. The ATP/ADP ratio ranged from 11 to 60 in the erythrocytes of the fish examined. 4.
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Activation of aspartate transcarbamoylase by purine nucleotides

Biochimica et Biophysica Acta (BBA) - Enzymology, 1970
Abstract 1. 1. A previous report demonstrated an increase in aspartate transcarbamoylase activity (carbamoylphosphate: l -aspartate carbamoyltransferase, EC 2.1.3.2) upon incubation of an homogenate of Escherichia coli with ATP, GTP, phosphoenolpyruvate, amino acids and magnesium acetate.
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Purine Nucleotide Restoration in HPRT- Cells

1989
Lesch-Nyhan syndrome is caused by a deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) (1, 2). This enzyme catalyzes the conversion of the purine bases hypoxanthine and guanine to their respective 5′ribo-nucleotides. It is reasonable to assume that a deficiency of HPRT would cause a decrease in the cellular concentrations of
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