Results 241 to 250 of about 144,015 (298)
Inhibition of human poly(A)-specific ribonuclease (PARN) by purine nucleotides: kinetic analysis
Journal of Enzyme Inhibition and Medicinal Chemistry, 2009 Poly(A)-specific ribonuclease (PARN) is a cap-interacting and poly(A)-specific 3'-exoribonuclease that efficiently degrades mRNA poly(A) tails. Based on the enzyme's preference for its natural substrates, we examined the role of purine nucleotides as ...
Nikolaos Balatsos +2 more
exaly +2 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Purine nucleotide catabolism in placenta
American Journal of Obstetrics and Gynecology, 1964Abstract Soluble extracts were utilized to delineate the catabolic pathways of purine 2′,3′- and 5′-ribonucleoside monophosphates in human placenta and to measure the relative activities of the enzymes involved. Derivatives of adenine and hypoxanthine are converted to hypoxanthine, and derivatives of guanine are converted to xanthine.
T T, HAYASHI +3 more
openaire +2 more sources
Alterations in purine nucleotide pyrophosphorylases and resistance to purine analogues
Biochimica et Biophysica Acta, 1961Abstract Resistance to purine analogues in mutants isolated from Salmonella typhimurium , strain LT-2 , resulted in the loss of specific purine nucleotide pyrophosphorylases. Thus, mutants resistant to 2,6-diaminopurine, 6-mercaptopurine, and 8-azaguanine lacked adenylic, inosinic and guanylic pyrophosphorylases, respectively. The mutants resistant
G P, KALLE, J S, GOTS
openaire +2 more sources
Thermodynamics of the purine nucleotide cycle
Biophysical Chemistry, 2006Since the standard Gibbs energies of formation are known for all the species in the purine nucleotide cycle at 298.15 K, the functions of pH and ionic strength that yield the standard transformed Gibbs energies of formation of the ten reactants can be calculated.
openaire +2 more sources
Purine Nucleotide Catabolism in Rat Liver
2006The higher specific radioactivity of ALL in comparison to UA, which are observed after administration of labelled precursors, changed when, oxonic acid and allopurinol, inhibitors of UA and ALL formation were administrated. To interpret these results, it is worth while to recall that nucleotide metabolism can be represented as a complex sequence ...
Marinello E. +5 more
openaire +4 more sources
Purine nucleotide cyclases in the malaria parasite
Trends in Parasitology, 2004Cells use a variety of signal transduction pathways to coordinate their responses to changes in both the extracellular and intracellular environment. Activation of these pathways is often receptor mediated, resulting in the synthesis of second messenger molecules such as cAMP and cGMP.
David A, Baker, John M, Kelly
openaire +2 more sources
3 Purine, Purine Nucleoside, and Purine Nucleotide Aminohydrolases
1971Publisher Summary This chapter discusses the chemical significance of adenosine aminohydrolase, 5′-adenylic acid aminohydrolase, adenine nucleoside, nucleotide aminohydrolase, guanine aminohydrolase, and guanosine aminohydrolase. The partially purified adenine aminohydrolase from Azotobacter vinelandii catalyzes the anaerobic conversion of adenine ...
openaire +1 more source
Disturbances of purine nucleotide metabolism in uremia
Seminars in Nephrology, 2004The increased concentration of adenosine triphosphate (ATP) in erythrocytes from patients with chronic renal failure (CRF) has been observed in many studies but the mechanism leading to these abnormalities still is controversial. It is believed that hyperphosphatemia and metabolic acidosis triggering enhanced reutilization of purine bases are the ...
Bolesław, Rutkowski +7 more
openaire +2 more sources
De Novo Purine Nucleotide Biosynthesis
1992This chapter reviews current understanding of de novo purine nucleotide synthesis in Bacillus subtilis,with emphasis on recent developments in understanding gene organization and regulation and on the distinctive structural features of two enzymes of the pathway.
H, Zalkin, J E, Dixon
openaire +2 more sources
Purine nucleotide biosynthesis in gastrointestinal mucosa
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1973Abstract Two methods were used to elucidate the relative dependence of intestinal mucosa on the alternative pathways of purine nucleotide biosynthesis. While salvage activity was high, there was no evidence of active de novo purine synthesis by either method, suggesting that intestinal mucosa is dependent on salvage pathway activity for the provision
A M, Mackinnon, D J, Deller
openaire +2 more sources