Results 221 to 230 of about 144,015 (298)

Cooperativity in E. coli aspartate transcarbamoylase is tuned by allosteric breathing. [PDF]

Nat Commun
Miller RC, Patterson MG, Bhatt N, Pei X, Ando N.   +4 more
europepmc   +1 more source

Nucleotide salvage, genome instability, and potential therapeutic applications. [PDF]

Nucleic Acids Res
Wang P, Wang C, Wang Y.
europepmc   +1 more source

Clonal Mosaicism of Mitochondrial DNA Heteroplasmy as a Molecular Clock of Aging

Aging Cell, Volume 25, Issue 9, September 2026.
Mitochondrial DNA mutations diverge by tissue dynamics across lifespan: dividing tissues accumulate pervasive point mutations via clonal stem‐cell expansion, whereas post‐mitotic tissues harbor clonally expanded large‐scale deletions, both culminating in age‐dependent, threshold‐limited respiratory failure.
Renin Chang, Andy P. Tsai, Boyang Wang, Kuan‐Hao Tsui, Cheng‐Yoong Pang, Chia‐Jung Li   +5 more
wiley   +1 more source

New Insights into Binding of G-segment DNA to the Active Site of Escherichia coli Topoisomerase III. [PDF]

Sci Rep
Tan K, Annamalai T, Stols L, Bhuiyan MAR, Tse-Dinh YC.   +4 more
europepmc   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

IMP metabolic mechanisms and IMPDH targeting strategies in tumor metabolic reprogramming and therapy (Review). [PDF]

Int J Mol Med
Zhu H, Wang H, Li X, Zhang W, Wang Y, Tan Q, Ying D, Shi Z, Song J.   +8 more
europepmc   +1 more source

Rational Design, Synthesis, Biological Evaluation, and In Silico Study of N‐Cinnamamide/Benzamide‐(4‐(Substituted Phenyl)‐6‐(4‐Cyclohexylphenyl)pyrimidin‐2‐Yl) Derivatives as EGFR Inhibitors Targeting EGFRWT, EGFRT790M, and EGFRL858R/T790M/C797S in NSCLC

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
Rational Design, Synthesis, Biological Evaluation, and In Silico Investigation of N‐Cinnamamide/Benzamide‐(4‐(Substituted Phenyl)‐6‐(4‐Cyclohexylphenyl)pyrimidin‐2‐yl) Derivatives as EGFR Inhibitors Targeting Wild‐Type and Mutant EGFR in NSCLC. ABSTRACT Non‐small cell lung cancer (NSCLC), driven by mutations in the epidermal growth factor receptor ...
Rohit Pal, Gurubasavaraja Swamy Purawarga Matada, Ghanshyam Teli, Manjushree BV, Anguraj Moulishankar, Viney Chawla, Pooja A. Chawla   +6 more
wiley   +1 more source

Dynamics of enzyme and metabolic profile of broilers fed black soldier fly (<i>Hermetiailucens</i>) larvae-based diets. [PDF]

Biochem Biophys Rep
Oladejo OA, Ibiwoye DO, Faniyi AA, Ayoola MO, Oguntunji AO, Ayansina AD, Dahunsi SO.   +6 more
europepmc   +1 more source

Association of Sodium‐Glucose Cotransporter‐2 Inhibitors With Incident Gout Risk: A Population‐Based Comparative Cohort Study With Genetic Evidence From Mendelian Randomisation

Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 8230-8241, September 2026.
ABSTRACT Aim Sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) are known to reduce serum urate levels, yet their specific impact on gout incidence in the Korean population remains underexplored. We investigated the association between SGLT2i use and incident gout using real‐world data and Mendelian randomisation (MR) analysis. Materials and Methods We
Hong Sang Choi, Jaejun Heo, Sungho Won, Sang Heon Suh, Chang Seong Kim, Eun Hui Bae, Juhee Ahn, Soo Wan Kim   +7 more
wiley   +1 more source

Changes in Purine Metabolism During Differentiation of Dopamine Neurons from Human Induced Pluripotent Stem Cells. [PDF]

Cell Mol Neurobiol
Grychowski L, Seifar F, Ozel E, Thite A, Sutcliffe DJ, Dinasarapu AR, Hess EJ, Jinnah HA.   +7 more
europepmc   +1 more source