Results 231 to 240 of about 47,484 (302)

Purine Nucleotide Precursors in Preventing Myocardial Ischemia-Reperfusion Injury. [PDF]

Int J Mol Sci
Musial PT, Badtke PA, Zabielska-Kaczorowska MA.   +2 more
europepmc   +1 more source

Elucidation of DNA Primase as a Drug Target in Leishmania donovani: Structure‐Guided Inhibitor Identification and Biochemical Validation

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
Structure‐guided and biochemical analyses indicate that DNA primase of Leishmania donovani represents a potential therapeutic target, as repurposed compounds, particularly Pritelivir, demonstrate marked inhibitory effects accompanied by reduced parasite proliferation, replication, and altered cellular morphology in in vitro and cell‐based studies ...
Deep Bhowmik, Anupama Sharma, Ravi Prakash Arya, Diwakar Kumar   +3 more
wiley   +1 more source

Current Perspectives on STING Agonists for Anticancer Drug Development

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
The molecular structures of STING agonists play a decisive role in regulating the STING pathway. Their distinct scaffolds and functional groups orchestrate receptor binding, conformational activation, and the subsequent immune response. ABSTRACT The cyclic GMP‐AMP (cGAS) synthase and stimulator of interferon genes signaling pathway plays a central role
Dilay Kahvecioglu Cicek
wiley   +1 more source

Inositol and Berberine Synergistically Reprogram Endocrine and Ovarian Metabolism in Polycystic Ovary Syndrome

Cell Proliferation, Volume 59, Issue 7, July 2026.
In a DHEA+HFD‐induced mouse model, Ins/BBR alleviated mitochondrial defects and broadly reprogrammed metabolic landscape in granulosa cells, in specific, restoring nucleotide pools and amino acid turnover, and preventing abnormal long‐chain fatty acid accumulation.
Juan Ge, Chenxiang Zhang, Yilong Zhao, Haiyang Zhao, Shuai Zhu, Tao Tang, Guorui Zhang, Qiang Wang, Hui Wang   +8 more
wiley   +1 more source

Repartitioning brain glucose: serine-nucleotide dependency sensitizes glioblastoma therapy. [PDF]

Signal Transduct Target Ther
Hong Y, Hua C, Wu M.
europepmc   +1 more source

An IMPDH2 variant associated with neurodevelopmental disorder disrupts purine biosynthesis and somite organization. [PDF]

Proc Natl Acad Sci U S A
O'Neill AG, McCartney ME, Wheeler GM, Patel JH, Sanchez-Ramirez G, Kollman JM, Wills AE.   +6 more
europepmc   +1 more source

A universal polyphosphate kinase powers in vitro transcription. [PDF]

Nat Commun
Matsumoto R, Watanabe T, Yamazaki E, Kagawa A, Longo LM, Matsuura T.   +5 more
europepmc   +1 more source

Investigating Polarity Effects in DNA Base Stacking. [PDF]

JACS Au
Abraham Punnoose J, Kam CS, Melfi T, Vangaveti S, Chen AA, Halvorsen K.   +5 more
europepmc   +1 more source

Biomimetic Studies on the Reactivity of Sulfur-Centered Radicals with Purine Moieties of DNA. [PDF]

Biomolecules
Masi A, Barata-Vallejo S, Chatgilialoglu C.   +2 more
europepmc   +1 more source