Results 251 to 260 of about 47,484 (302)
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Disturbances of purine nucleotide metabolism in uremia
Seminars in Nephrology, 2004The increased concentration of adenosine triphosphate (ATP) in erythrocytes from patients with chronic renal failure (CRF) has been observed in many studies but the mechanism leading to these abnormalities still is controversial. It is believed that hyperphosphatemia and metabolic acidosis triggering enhanced reutilization of purine bases are the ...
Bolesław, Rutkowski +7 more
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3 Purine, Purine Nucleoside, and Purine Nucleotide Aminohydrolases
1971Publisher Summary This chapter discusses the chemical significance of adenosine aminohydrolase, 5′-adenylic acid aminohydrolase, adenine nucleoside, nucleotide aminohydrolase, guanine aminohydrolase, and guanosine aminohydrolase. The partially purified adenine aminohydrolase from Azotobacter vinelandii catalyzes the anaerobic conversion of adenine ...
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Purine nucleotide biosynthesis in gastrointestinal mucosa
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1973Abstract Two methods were used to elucidate the relative dependence of intestinal mucosa on the alternative pathways of purine nucleotide biosynthesis. While salvage activity was high, there was no evidence of active de novo purine synthesis by either method, suggesting that intestinal mucosa is dependent on salvage pathway activity for the provision
A M, Mackinnon, D J, Deller
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Studies of the Regulation of Purine Nucleotide Catabolism
Canadian Journal of Biochemistry, 1975Ehrlich ascites tumor cells containing radioactive ATP were incubated in vitro with a range of concentrations of 2-deoxyglucose in order to produce different rates of ATP catabolism. Concentrations of all radioactive products of ATP catabolism were measured, and apparent rates of adenylate deaminase and inosinate dehydrogenase and of adenylate and ...
C A, Lomax, A S, Bagnara, J F, Henderson
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Degradation of Purine Nucleotides
1978Purine nucleotides have a vital role in metabolism. Therefore, the maintenance of a constant nucleotide composition of the cell is essential for normal function. Purine nucleotides are synthesized by purine biosynthesis de novo, by salvage pathways and nucleoside kinases, and by degradation of nucleic acids.
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De Novo Purine Nucleotide Biosynthesis
1992This chapter reviews current understanding of de novo purine nucleotide synthesis in Bacillus subtilis,with emphasis on recent developments in understanding gene organization and regulation and on the distinctive structural features of two enzymes of the pathway.
H, Zalkin, J E, Dixon
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Purine nucleotides as regulators of vessel tone
Biochemical Society Transactions, 19885‘-isobutylthioadenosine, but it was inhibited by 10 mMp-nitrophenylphsphate to 50 k 11% ( n = 6). The inhibition of the pigeon ventricle AMPase by other nucleoside monophosphates (with specificity for the base moeity), but not by ribose phosphate or B-glycerophosphate, indicates the presence of a 5’-nucleotidase.
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Advances in biochemical psychopharmacology, 1977
The existence of nonadrenergic, noncholinergic nerve components in the autonomic nervous system is now well established. They are strongly represented in the gastrointestinal tract of all vertebrates and have been identified in a variety of other organs, including lung, trachea, bladder, esophagus, eye, seminal vesicles, and possibly parts of the ...
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The existence of nonadrenergic, noncholinergic nerve components in the autonomic nervous system is now well established. They are strongly represented in the gastrointestinal tract of all vertebrates and have been identified in a variety of other organs, including lung, trachea, bladder, esophagus, eye, seminal vesicles, and possibly parts of the ...
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Purine Nucleotide Interconversions
1978The various reactions of purine ribonucleotide synthesis result in the formation of adenylate, inosinate, and guanylate; xanthylate may also be formed, but this seems to be a quantitatively minor process in most mammalian cells. These purine ribonucleoside monophosphates can be metabolized in several different ways; these processes can in general be ...
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Purine Nucleotide Content in the Leukocytes of Leukemia Patients
1995Purine nucleotides play an important role in cell life: they are precursors of RNA and DNA, and act as coenzymes and condensers of energy. The evaluation of their metabolism under physiological and pathological conditions is therefore of great interest.
Carlucci F. +8 more
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