Results 61 to 70 of about 47,484 (302)

Mechanosensitive Hydrolysis of ATP and ADP in Lamina Propria of the Murine Bladder by Membrane-Bound and Soluble Nucleotidases

Frontiers in Physiology, 2022
Prior studies suggest that urothelium-released adenosine 5′-triphosphate (ATP) has a prominent role in bladder mechanotransduction. Urothelial ATP regulates the micturition cycle through activation of purinergic receptors that are expressed in many cell ...
Mafalda S. L. Aresta Branco, Alejandro Gutierrez Cruz, Jacob Dayton, Brian A. Perrino, Violeta N. Mutafova-Yambolieva   +4 more
doaj   +1 more source

A General Enzymatic Strategy for Site‐Specific Incorporation of Modified Genetic Building Blocks Into DNA

Advanced Science, EarlyView.
Eco‐friendly enzymatic synthesis of high‐fidelity, site‐specifically modified DNA using 3′‐blocked nucleotides for full synthetic control and next‐generation sequencing compatibility. ABSTRACT Methods for site‐specific incorporation of modified DNA building blocks remain limited.
Raveena Raveena, Bhavana Ramadas, Sidney Becker   +2 more
wiley   +1 more source

Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach

Advanced Science, EarlyView.
The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen, Jiayi Liang, Yujia Wu, Jianan Xu, Yi Liu, Wenguang Wang, Xinhang Jiang, Benjie Gao, Yueyue Wang, Hui Jiang   +9 more
wiley   +1 more source

Light‐Activated Ruthenium Nanoclusters Reprogram the Metabolic‐Quorum Sensing Axis for Precision Periodontitis Therapy

Advanced Science, EarlyView.
Under 660 nm visible light, Ru NCs efficiently photocatalyze nitrate‐to‐ammonium conversion and modulate oral nitrogen metabolism. They precisely perturb Veillonella parvula, block its key support to Porphyromonas gingivalis, and exert an “inhibiting without killing” antivirulence effect.
Jing Zhou, Xiaolin Sun, Chengyu Liu, Yujia Shi, Meiqi Li, Meng Bo, Jingjie Zhai, Chunyan Li, Zhennan Wu, Xue Bai, Lin Wang   +10 more
wiley   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

A Homogeneous Cyclic Cmp Phospho Di Esterase Hydrolyzes Both Pyrimidine and Purine Cyclic 2' 3' Nucleotides and 3' 5' Nucleotides [PDF]

, 1982
A homogeneous preparation of [pig liver] cyclic[c]CMP phosphodiesterase catalyzes the hydrolysis of both pyrimidine and purine cyclic 2':3'- and 3':5'-nucleotides.
Helfman, D. M., Kuo, J. F.
core  

Diguanosine 5′ ,5‴-P1 ,P4-tetraphosphate and other purine nucleotides inhibit endoribonuclease VI from Artemia [PDF]

, 1988
The activity of the endoribonuclease VI from Artemia is sensitive to several purine nucleotides. The enzyme is non-competitively inhibited by diguanosine tetraphosphate (Ki = 75 μM), a nucleotide abundant in Artemia encysted gastrulae and located in the ...
Heredia, Claudio F., Pilar P. Grau, Grau, Pilar P., Claudio F. Heredia   +3 more
core   +1 more source

Metagenomic Association Uncovers Host Genotype‐Structured Rhizobacterial Networks and Novel Taxa That Enhance Soybean Salt Tolerance

Advanced Science, EarlyView.
An STI‐guided metagenomic association framework links soybean salt‐tolerance phenotypes with rhizosphere microbiome composition and network organization in natural saline soils. The approach identifies candidate beneficial taxa, including Thalassospira xiamenensis, and provides an efficient strategy for mining stress‐protective microbes from native ...
Yu Luo, Feng‐Li Kang, Qi‐Min Li, Wei‐Cai Yang   +3 more
wiley   +1 more source

Concentrations of Purine Nucleotides and Purine and Pyrimidine Bases in Cerebrospinal Fluid of Neurologically Healthy Children [PDF]

, 1992
Summary: The concentrations of the nucleotides AMP and IMP, the nucleosides adenosine, guanosine and inosine, the purine bases adenine, guanine, hypoxanthine and xanthine, urate, and the pyrimidine bases cytosine, thymine and uracil were determined by ...
M. Castro-gago, Rodríguez-Núñez, A., S. Rodriguez-segade, Castro-Gago, M., S. Lojo, Camiña, F., Rodríguez-Segade, S., F. Camina, Lojo, S., A. Rodriguez-nunez   +9 more
core   +1 more source

Post-translational regulation of P2X receptor channels: modulation by phospholipids

Frontiers in Cellular Neuroscience, 2013
P2X receptor channels mediate fast excitatory signaling by ATP and play major roles in sensory transduction, neuro-immune communication and inflammatory response.
Louis-Philippe eBernier, Ariel eAse, Philippe eSeguela   +2 more
doaj   +1 more source