Results 41 to 50 of about 47,484 (302)

Yeast to Study Human Purine Metabolism Diseases

Cells, 2019
Purine nucleotides are involved in a multitude of cellular processes, and the dysfunction of purine metabolism has drastic physiological and pathological consequences.
Bertrand Daignan-Fornier, Benoît Pinson
doaj   +1 more source

Ectonucleotidases in Acute and Chronic Inflammation

Frontiers in Pharmacology, 2021
Ectonucleotidases are extracellular enzymes with a pivotal role in inflammation that hydrolyse extracellular purine and pyrimidine nucleotides, e.g., ATP, UTP, ADP, UDP, AMP and NAD+. Ectonucleotidases, expressed by virtually all cell types, immune cells
Anna Lisa Giuliani, Alba Clara Sarti, Francesco Di Virgilio   +2 more
doaj   +1 more source

A.: Mechanisms of synthesis of purine nucleotides in heart muscle extracts [PDF]

, 1957
The key role of ATP, a purine nucleotide, in the conversion of chemical energy into mechanical work by myocardial tissue is well established (1, 2). The requirement for purine nucleotides has also been demonstrated in the multiple synthetic reactions ...
David A. Goldthwait, A. Goldthwait
core   +1 more source

Divergent Prebiotic Synthesis of Pyrimidine and 8-Oxo-purine Ribonucleotides [PDF]

, 2017
Understanding prebiotic nucleotide synthesis is a long standing challenge thought to be essential to elucidating the origins of life on Earth. Recently, remarkable progress has been made, but to date all proposed syntheses account separately for the ...
Powner, Matthew W., Dejan-Krešimir Bučar, Bucar, D-K, Nikmal, Arif, Stairs, S, Zheng, S-L, Powner, MW, Zheng, Shao-Liang, Jack W. Szostak, Arif Nikmal, Shaun Stairs, Szostak, Jack, Shao-Liang Zheng, Stairs, Shaun, Nikmal, A, Szostak, JW, Bučar, Dejan-Krešimir, Matthew W. Powner   +17 more
core   +4 more sources

Analysis of substrate specificity and kinetics of cyclic nucleotide phosphodiesterases with N'-methylanthraniloyl-substituted purine and pyrimidine 3',5'-cyclic nucleotides by fluorescence spectrometry.

PLoS ONE, 2013
As second messengers, the cyclic purine nucleotides adenosine 3',5'-cyclic monophosphate (cAMP) and guanosine 3',5'-cyclic monophosphate (cGMP) play an essential role in intracellular signaling.
Daniel Reinecke, Frank Schwede, Hans-Gottfried Genieser, Roland Seifert   +3 more
doaj   +1 more source

Co-therapy with S-adenosylmethionine and nicotinamide riboside improves t-cell survival and function in Arts Syndrome (PRPS1 deficiency)

Molecular Genetics and Metabolism Reports, 2021
Arts syndrome or phosphoribosyl-pyrophosphate-synthetase-1 (PRPS1) deficiency is caused by loss-of-function mutations in the PRPS1 gene (Xq22.3). PRPS1 is an initial and essential step for the synthesis of the nucleotides of purines, pyrimidines, and ...
Nina Lenherr, John Christodoulou, John Duley, Doreen Dobritzsch, Lynette Fairbanks, Alexandre N. Datta, Isabel Filges, Nicolas Gürtler, Jeroen Roelofsen, André B.P. van Kuilenburg, Claudia Kemper, Erin E. West, Gabor Szinnai, Martina Huemer   +13 more
doaj   +1 more source

Levels and variability of purine nucleotides in normal human lymphocytes [PDF]

, 1992
Anion-exchange, high performance liquid chromatography was used to determine purine nucleotides in lymphocytes of healthy males and females of various ages.
LEONCINI, ROBERTO, Tagliaferri P., CARLUCCI, FILIPPO, PORCELLI, BRUNETTA, Consolmagno E., TABUCCHI, ANTONELLA, Pagani, Marinello E.   +7 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Comparison of the stabilities and solution structures of metal ion complexes formed with 5'-di- and 5'-triphosphates of purine nucleosides [PDF]

, 2003
Nucleotides and metal ions are involved in the basic metabolic processes of life, participating as substrates in enzymatic reactions in the form of metal ion complexes.
Minari Bianchi, Emanuela
core   +1 more source

DNA‐Templated 2D Heterostructures as Phototriggered Dynamic Nanohybrids: From Releasing Molecular Loads to Controlling Enzyme Biocatalytic Function

Advanced Functional Materials, EarlyView.
DNA strands are employed both as dynamic linkers and nanoscale templates for the integration of Ag2S nanoparticles on MoS2, which in turn imparted photothermal responsiveness; this feature permits the selective cargo (fluorophore, quantum dots or an enzyme) release from the MoS2 surface in response to local heat induced by light irradiation.
Kai Chen, Haosen Miao, Weiying Hong, Matteo Palma   +3 more
wiley   +1 more source