Results 21 to 30 of about 77,981 (273)

De Novo Purine Nucleotide Biosynthesis Pathway Is Required for Development and Pathogenicity in Magnaporthe oryzae

Journal of Fungi, 2022
Purine nucleotides are indispensable compounds for many organisms and participate in basic vital activities such as heredity, development, and growth. Blocking of purine nucleotide biosynthesis may inhibit proliferation and development and is commonly ...
Meng-Yu Liu, Li-Xiao Sun, Hui Qian, Yun-Ran Zhang, Xue-Ming Zhu, Lin Li, Shuang Liang, Jian-Ping Lu, Fu-Cheng Lin, Xiao-Hong Liu   +9 more
doaj   +1 more source

Atomic mutagenesis of stop codon nucleotides reveals the chemical prerequisites for release factor-mediated peptide release. [PDF]

, 2018
Termination of protein synthesis is triggered by the recognition of a stop codon at the ribosomal A site and is mediated by class I release factors (RFs).
Clementi, Nina, Erlacher, Matthias David, Faserl, Klaus, Gasser, Catherina, Hoernes, Thomas Philipp, Hüttenhofer, Alexander, Joseph, Simpson, Juen, Michael Andreas, Kreutz, Christoph, Lindner, Herbert, Shi, Xinying, Willi, Jessica   +11 more
core   +3 more sources

FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle [PDF]

Cell, 2020
Mutations in FAMIN cause arthritis and inflammatory bowel disease in early childhood, and a common genetic variant increases risk for Crohn’s disease and leprosy. We developed an unbiased liquid chromatography mass spectrometry screen for enzymatic activity of this orphan protein.
Cader, M Zaeem, Rodrigues, Rodrigo Pereira De Almeida, West, James A, Sewell, Gavin W, Md-Ibrahim, Muhammad N, Reikine, Stephanie, Sirago, Giuseppe, Unger, Lukas W, Iglesias Romero, Ana Bélen, Ramshorn, Katharina, Haag, Lea-Maxie, Saveljeva, Svetlana, Ebel, Jana-Fabienne, Rosenstiel, Philip, Kaneider-Kaser, Nicole C, Lee, James C, Lawley, Trevor D, Bradley, Allan, Dougan, Gordon, Modis, Yorgo, Griffin, Julian L, Kaser, Arthur   +21 more
openaire   +7 more sources

Urinary ATP Levels Are Controlled by Nucleotidases Released from the Urothelium in a Regulated Manner

Metabolites, 2022
Adenosine 5′-triphosphate (ATP) is released in the bladder lumen during filling. Urothelial ATP is presumed to regulate bladder excitability. Urinary ATP is suggested as a urinary biomarker of bladder dysfunctions since ATP is increased in the urine of ...
Alejandro Gutierrez Cruz, Mafalda S. L. Aresta Branco, Brian A. Perrino, Kenton M. Sanders, Violeta N. Mutafova-Yambolieva   +4 more
doaj   +1 more source

Single-molecule microscopy reveals new insights into nucleotide selection by DNA polymerase I. [PDF]

, 2012
The mechanism by which DNA polymerases achieve their extraordinary accuracy has been intensely studied because of the linkage between this process and mutagenesis and carcinogenesis. Here, we have used single-molecule fluorescence microscopy to study the
Markiewicz, RP, Romano, LJ, Rueda, D, Vrtis, KB   +3 more
core   +1 more source

Mitochondrial-encoded membrane protein transcripts are pyrimidine-rich while soluble protein transcripts and ribosomal RNA are purine-rich

BMC Genomics, 2005
Background Eukaryotic organisms contain mitochondria, organelles capable of producing large amounts of ATP by oxidative phosphorylation. Each cell contains many mitochondria with many copies of mitochondrial DNA in each organelle.
Samuels David C, Rathi Anand, Bradshaw Patrick C   +2 more
doaj   +1 more source

One-carbon metabolism in cancer [PDF]

, 2017
Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells.
AJ MacFarlane, Alice C Newman, AS Tibbetts, B Chaneton, BC Blount, C Commisso, CA Lewis, CF Labuschagne, CF Woeller, D Hanahan, D Hanahan, D Kim, DD Anderson, E Currie, E Mullarky, F Daidone, F Kottakis, G Kikuchi, GM DeNicola, Gregory S. Ducker, GS Ducker, J Liu, J Meiser, J Ye, Jason W. Locasale, JJ Kamphorst, JW Locasale, K Snell, K Snell, K Snell, Katherine R. Mattaini, L Galluzzi, M Goulian, M Jain, M Kulis, Mahya Mehrmohamadi, ME Pacold, Ming Yang, MJ Osborn, ML Rose, ML Rose, OD Maddocks, OD Maddocks, Oliver D K Maddocks, Oliver D. K. Maddocks, PM Ueland, R Possemato, S Farber, S Kit, S Pollari, SJ Mentch, Swetha Bolusani, T Shlomi, WC Zhang, Y Fu, Z Ser   +55 more
core   +1 more source

De novo nucleotide biosynthetic pathway and cancer

Genes and Diseases, 2023
De novo nucleotide biosynthetic pathway is a highly conserved and essential biochemical pathway in almost all organisms. Both purine nucleotides and pyrimidine nucleotides are necessary for cell metabolism and proliferation.
Jie Chen, Siqi Yang, Yingge Li, Xu Ziwen, Pingfeng Zhang, Qibin Song, Yi Yao, Huadong Pei   +7 more
doaj   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Purine metabolism in the light of aerobic and anaerobic capacity of female boxers

Central European Journal of Sport Sciences and Medicine, 2020
The aim of the work was to assess the intensity of purine nucleotide degradation during maximum physical exercise. 5 elite female boxers were the subject of the study.
Katarzyna Domaszewska, Piotr Szewczyk, Jakub Kryściak, Edyta Michalak, Tomasz Podgórski   +4 more
doaj   +1 more source