Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase [PDF]
Cell Reports, 2017 Pharmacologic agents that interfere with nucleotide metabolism constitute an important class of anticancer agents. Recent studies have demonstrated that mTOR complex 1 (mTORC1) inhibitors suppress de novo biosynthesis of pyrimidine and purine nucleotides.
Natasha Emmanuel +9 more
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Proton conductance by human uncoupling protein 1 is inhibited by purine and pyrimidine nucleotides [PDF]
The EMBO JournalUncoupling protein 1 (UCP1, SLC25A7) is responsible for the thermogenic properties of brown adipose tissue. Upon fatty acid activation, UCP1 facilitates proton leakage, dissipating the mitochondrial proton motive force to release energy as heat.
Scott A Jones +9 more
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Plasma membrane-located purine nucleotide transport proteins are key components for host exploitation by microsporidian intracellular parasites. [PDF]
PLoS Pathogens, 2014 Microsporidia are obligate intracellular parasites of most animal groups including humans, but despite their significant economic and medical importance there are major gaps in our understanding of how they exploit infected host cells.
Eva Heinz +11 more
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Purine Metabolism and Rett Syndrome [PDF]
Pediatric Neurology Briefs, 1996 Levels of purine and pyridine nucleotides and their metabolites were determined in erythrocytes and plasma of 31 Rett pattients and 17 age-matched controls at the Departments of Molecular Biology and Child Psychiatry, University of Siena, Children’s ...
J Gordon Millichap
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Probing ligand selectivity in pathogens
eLife, 2023 Why does protein kinase A respond to purine nucleosides in certain pathogens, but not to the cyclic nucleotides that activate this kinase in most other organisms?
Bryan VanSchouwen, Giuseppe Melacini
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FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle [PDF]
Cell, 2020 Mutations in FAMIN cause arthritis and inflammatory bowel disease in early childhood, and a common genetic variant increases risk for Crohn’s disease and leprosy. We developed an unbiased liquid chromatography mass spectrometry screen for enzymatic activity of this orphan protein.
Cader, M Zaeem +21 more
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Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway
Nature Communications, 2022 Nucleotides are essential for different biological processes and have been also associated to cancer development. Depleting cellular nucleotides is a strategy commonly employed to target cancers.
Mona Hoseini Soflaee +20 more
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Metabolic engineering of the purine biosynthetic pathway in Corynebacterium glutamicum results in increased intracellular pool sizes of IMP and hypoxanthine [PDF]
, 2012 Background: Purine nucleotides exhibit various functions in cellular metabolism. Besides serving as building blocks for nucleic acid synthesis, they participate in signaling pathways and energy metabolism.
Sarah Zimmet +11 more
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Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides [PDF]
, 1989 Human neutrophils and HL-60 leukaemic cells possess an NADPH oxidase which catalyses superoxide (O2-) formation and is activated by the chemotactic peptide, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe).
Seifert, Roland +2 more
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Potential Mechanisms Connecting Purine Metabolism and Cancer Therapy
Frontiers in Immunology, 2018 Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of nucleotides in cell proliferation, thus impaired purine metabolism is associated with the progression of cancer.
Jie Yin +9 more
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