Results 11 to 20 of about 144,015 (298)

Proton conductance by human uncoupling protein 1 is inhibited by purine and pyrimidine nucleotides [PDF]

The EMBO Journal
Uncoupling protein 1 (UCP1, SLC25A7) is responsible for the thermogenic properties of brown adipose tissue. Upon fatty acid activation, UCP1 facilitates proton leakage, dissipating the mitochondrial proton motive force to release energy as heat.
Scott A Jones, Alice P Sowton, Denis Lacabanne, Martin S King, Shane M Palmer, Thomas Zögg, Els Pardon, Jan Steyaert, Jonathan J Ruprecht, Edmund R S Kunji   +9 more
doaj   +7 more sources

Plasma membrane-located purine nucleotide transport proteins are key components for host exploitation by microsporidian intracellular parasites. [PDF]

PLoS Pathogens, 2014
Microsporidia are obligate intracellular parasites of most animal groups including humans, but despite their significant economic and medical importance there are major gaps in our understanding of how they exploit infected host cells.
Eva Heinz, Christian Hacker, Paul Dean, John Mifsud, Alina V Goldberg, Tom A Williams, Sirintra Nakjang, Alison Gregory, Robert P Hirt, John M Lucocq, Edmund R S Kunji, T Martin Embley   +11 more
doaj   +2 more sources

Probing ligand selectivity in pathogens

eLife, 2023
Why does protein kinase A respond to purine nucleosides in certain pathogens, but not to the cyclic nucleotides that activate this kinase in most other organisms?
Bryan VanSchouwen, Giuseppe Melacini
doaj   +1 more source

Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway

Nature Communications, 2022
Nucleotides are essential for different biological processes and have been also associated to cancer development. Depleting cellular nucleotides is a strategy commonly employed to target cancers.
Mona Hoseini Soflaee, Rushendhiran Kesavan, Umakant Sahu, Alpaslan Tasdogan, Elodie Villa, Zied Djabari, Feng Cai, Diem H. Tran, Hieu S. Vu, Eunus S. Ali, Halie Rion, Brendan P. O’Hara, Sherwin Kelekar, James Hughes Hallett, Misty Martin, Thomas P. Mathews, Peng Gao, John M. Asara, Brendan D. Manning, Issam Ben-Sahra, Gerta Hoxhaj   +20 more
doaj   +1 more source

FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle [PDF]

Cell, 2020
Mutations in FAMIN cause arthritis and inflammatory bowel disease in early childhood, and a common genetic variant increases risk for Crohn’s disease and leprosy. We developed an unbiased liquid chromatography mass spectrometry screen for enzymatic activity of this orphan protein.
Cader, M Zaeem, Rodrigues, Rodrigo Pereira De Almeida, West, James A, Sewell, Gavin W, Md-Ibrahim, Muhammad N, Reikine, Stephanie, Sirago, Giuseppe, Unger, Lukas W, Iglesias Romero, Ana Bélen, Ramshorn, Katharina, Haag, Lea-Maxie, Saveljeva, Svetlana, Ebel, Jana-Fabienne, Rosenstiel, Philip, Kaneider-Kaser, Nicole C, Lee, James C, Lawley, Trevor D, Bradley, Allan, Dougan, Gordon, Modis, Yorgo, Griffin, Julian L, Kaser, Arthur   +21 more
openaire   +4 more sources

Metabolic engineering of the purine biosynthetic pathway in Corynebacterium glutamicum results in increased intracellular pool sizes of IMP and hypoxanthine [PDF]

, 2012
Background: Purine nucleotides exhibit various functions in cellular metabolism. Besides serving as building blocks for nucleic acid synthesis, they participate in signaling pathways and energy metabolism.
Sarah Zimmet, Susanne Peifer, Elmar Heinzle, Heinzle, Elmar, Dietrich A Volmer, Schneider, Konstantin, Konstantin Schneider, Barduhn, Tobias, Volmer, Dietrich A., Tobias Barduhn, Zimmet, Sarah, Peifer, Susanne   +11 more
core   +1 more source

Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides [PDF]

, 1989
Human neutrophils and HL-60 leukaemic cells possess an NADPH oxidase which catalyses superoxide (O2-) formation and is activated by the chemotactic peptide, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe).
Seifert, Roland, Schultz, Günter, Burde, R.   +2 more
core   +1 more source

Potential Mechanisms Connecting Purine Metabolism and Cancer Therapy

Frontiers in Immunology, 2018
Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of nucleotides in cell proliferation, thus impaired purine metabolism is associated with the progression of cancer.
Jie Yin, Jie Yin, Jie Yin, Wenkai Ren, Xingguo Huang, Xingguo Huang, Jinping Deng, Tiejun Li, Yulong Yin, Yulong Yin   +9 more
doaj   +1 more source

Biosensor measurement of purine release from cerebellar cultures and slices [PDF]

, 2010
We have previously described an action-potential and Ca2+-dependent form of adenosine release in the molecular layer of cerebellar slices. The most likely source of the adenosine is the parallel fibres, the axons of granule cells. Using microelectrode
Eason, Robert, Robert Eason, Dale, Nicholas, Wall, Mark J., Mark Wall, Nicholas Dale   +5 more
core   +1 more source

Characterisation of multiple substrate-specific (d)ITP/(d)XTPase and modelling of deaminated purine nucleotide metabolism [PDF]

, 2011
To be viable, organisms possess a number of (deoxy)nucleotide phosphohydrolases, which hydrolyze these nucleotides removing them from the active NTP and dNTP pools. Deamination of purine bases can result in accumulation of such nucleotides as ITP, dITP,
Davies, Oluwafemi, Mendes, Pedro, Naglis Malys, Smallbone, Kieran, Pedro Mendes, Malys, Naglis, Smallbone, Kiera, Kieran Smallbone, Oluwafemi Davies   +8 more
core   +1 more source