Results 1 to 10 of about 45,190 (164)
Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity [PDF]
Molecular Metabolism, 2018 Objective: Non-shivering thermogenesis in mammalian brown adipose tissue depends on thermogenic uncoupling protein 1. Its activity is triggered by free fatty acids while purine nucleotides mediate inhibition.
Tobias Fromme +2 more
exaly +4 more sources
Purine Nucleotides in the Regulation of Brown Adipose Tissue Activity [PDF]
Frontiers in Endocrinology, 2020 Non-shivering thermogenesis in mammalian brown adipose tissue is a powerful mechanism to defend normothermia in cold climates. To minimize the loss of chemical energy, the central functional component, mitochondrial uncoupling protein 1, UCP1, must be ...
Andrea Bast-Habersbrunner +3 more
doaj +2 more sources
Effects of purine nucleotide administration on purine nucleotide metabolism in brains of heroin-dependent rats [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2016 Heroin is known to enhance catabolism and inhibit anabolism of purine nucleotides, leading to purine nucleotide deficiencies in rat brains. Here, we determined the effect of exogenous purine nucleotide administration on purine nucleotide metabolism in ...
Kun Li +3 more
doaj +3 more sources
Serine starvation suppresses the progression of esophageal cancer by regulating the synthesis of purine nucleotides and NADPH [PDF]
Cancer & MetabolismSerine metabolism provides important metabolic intermediates that support the rapid proliferation of tumor cells. However, the role of serine metabolism in esophageal squamous cell carcinoma (ESCC) and the underlying mechanism remains unclear.
Hui Jie +12 more
doaj +2 more sources
Phytohormones: structural and functional relationship to purine nucleotides and some pharmacologic agents [PDF]
Plant Signaling and Behavior, 2021 Williams WR.
exaly +2 more sources
Research Advances in Purine Phosphoribosyltransferases of Protozoan Parasites
Guangdong nongye kexue, 2023 Parasitic protozoa are single-celled organisms that have adapted to live in cells of humans and animals. The protozoan parasites include Leishmania spp., Trypanosoma spp., Plasmodium spp., Toxoplasma gondii, Cryptosporidium spp., and Eimeria spp., which ...
Zhihui YU +7 more
doaj +1 more source
Molecular determinants of inhibition of UCP1-mediated respiratory uncoupling
Nature Communications, 2023 Brown adipose tissue expresses uncoupling protein 1 (UCP1), which dissipates energy as heat, making it a target for treating metabolic disorders. Here, we investigate how purine nucleotides inhibit respiration uncoupling by UCP1.
Antoine Gagelin +7 more
doaj +1 more source
Inborn Errors of Purine Salvage and Catabolism
Metabolites, 2023 Cellular purine nucleotides derive mainly from de novo synthesis or nucleic acid turnover and, only marginally, from dietary intake. They are subjected to catabolism, eventually forming uric acid in humans, while bases and nucleosides may be converted ...
Marcella Camici +6 more
doaj +1 more source
Biotechnology for Biofuels and Bioproducts, 2022 Background Purine nucleosides play essential roles in cellular physiological processes and have a wide range of applications in the fields of antitumor/antiviral drugs and food. However, microbial overproduction of purine nucleosides by de novo metabolic
Aihua Deng +7 more
doaj +1 more source
Chemistry, 2023 A styrylpyridine-containing cyclophane with diethylenetriamine linkers is presented as a host system whose association with representative nucleotides was examined with photometric and fluorimetric titrations.
Julika Schlosser +3 more
doaj +1 more source