Results 41 to 50 of about 7,019 (140)
The Role of Ion Channels in Pulmonary Hypertension: A Review
Pulmonary Circulation, Volume 15, Issue 1, January 2025.ABSTRACT Pulmonary hypertension (PH) constitutes a critical challenge in cardiopulmonary medicine with a pathogenesis that is multifaceted and intricate. Ion channels, crucial determinants of cellular electrochemical gradient modulation, have emerged as significant participants in the pathophysiological progression of PH.
Han‐Fei Li +11 more
wiley +1 more source
Release of ATP in the ventral medulla during hypoxia in rats: role in hypoxic ventilatory response [PDF]
, 2005 P2X2 receptor subunits of the ATP-gated ion channels are expressed by physiologically identified respiratory neurons in the ventral respiratory column, implicating ATP in the control of respiratory activity.
Dale, Nicholas +3 more
core +2 more sources
P2 purinoceptors signaling in fibroblasts of rat subcutaneous tissue [PDF]
, 2011 Mestrado em Biologia Molecular e CelularO tecido conjuntivo parece estar envolvido na génese de diversas condições patológicas. O aumento da rigidez do tecido conjuntivo, resultante da fibrose, pode constituir um factor importante no mecanismo patogénico
Reis, Carla Patrícia da Silva e Sousa
core +1 more source
P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes [PDF]
, 2008 ATP plays an important role in signal transduction between neuronal and glial circuits and within glial networks. Here we describe currents activated by ATP in astrocytes acutely isolated from cortical brain slices by non-enzymatic mechanical ...
Kirchhoff, Frank +6 more
core +1 more source
Role of inflammasomes and neuroinflammation in epilepsy
Immunological Reviews, Volume 329, Issue 1, January 2025.Summary Epilepsy is a brain disorder characterized by recurrent seizures, which are brief episodes of abnormal electrical activity in the brain and involuntary movement that can lead to physical injury and loss of consciousness. Seizures are canonically accompanied by increased inflammatory cytokine production that promotes neuroinflammation, brain ...
Ava Hollis, John R. Lukens
wiley +1 more source
Changes in P2Y Purinergic Receptor Expression in the Ciliary Body in a Murine Model of Glaucoma [PDF]
, 2017 Glaucoma is a neuropathology, often accompanied by an elevated intraocular pressure (IOP), which can lead to blindness. Since DBA/2J mice develop glaucoma, several studies of the physiopathology of glaucoma have been reported in this animal model.
Fonseca Vázquez, Begoña +5 more
core +2 more sources
Advanced Science, Volume 11, Issue 45, December 4, 2024.Exact knowledge about interactions and effects of engineered nanoparticles with the pulmonary microcirculation are instrumental for future application of this technology in patients. Using intravital microscopy, this study unravels the complex cascade of neutrophil recruitment during QD nanoparticle‐induced sterile inflammation in the lung ...
Chenxi Li +14 more
wiley +1 more source
Investigation of the functional expression of purine and pyrimidine receptors in porcine isolated pancreatic arteries [PDF]
, 2013 Receptors for purines and pyrimidines are expressed throughout the cardiovascular system. This study investigated their functional expression in porcine isolated pancreatic arteries.
Alsaqati, M. +2 more
core +3 more sources
Biotechnological Interventions for the Production of Subunit Vaccines Against Group A Rotavirus
Cell Biochemistry and Function, Volume 42, Issue 8, December 2024.ABSTRACT Group A rotavirus (RVA) is a major cause of severe gastroenteritis in infants and young children globally, despite the availability of live‐attenuated vaccines. Challenges such as limited efficacy in low‐income regions, safety concerns for immunocompromised individuals, and cold‐chain dependency necessitate alternative vaccine strategies ...
Mukta Prajapati +10 more
wiley +1 more source
European Journal of Immunology, Volume 54, Issue 12, December 2024.The absence of adenosine receptor A2B on myeloid cells in Adora2B923f/f‐LysMCre mice resulted in systemic changes in myeloid and lymphoid cell populations during pregnancy. There was an increased expression of IL‐6 and a reduction of MDSC and uNK cells. However, there were only marginal differences in pregnancy outcomes.
Stefanie Dietz +8 more
wiley +1 more source