Results 41 to 50 of about 7,481 (163)
Molecular Pain, 2009 Background The translocation of neuronal nitric oxide synthase (nNOS) from the cytosol to the membrane is functionally coupled to the activation of N-methyl-D-aspartate (NMDA) receptors at synapses.
Ohnishi Takayuki +2 more
doaj +1 more source
Spatio‐Temporal Diversity of Calcium Activity in Microglia
Glia, Volume 74, Issue 3, March 2026.Ca2+ activity mostly occurs in microglial processes and stays localized. When it spreads, it often shows a directional bias and is constrained by branch points. Activity strongly relies on P2Y12 receptors and is shaped by neuronal activity. ABSTRACT Microglia, the brain's innate immune cells, possess complex, highly motile branched processes. These act
Hiroshi Horiuchi +3 more
wiley +1 more source
Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Qianlu Yang, Jie Yan, Qianxi Yang
wiley +1 more source
Purinergic Receptor Antagonists Inhibit Hemolysis Induced by Clostridium perfringens Alpha Toxin
PathogensClostridium perfringens alpha toxin (CPA), which causes yellow lamb disease in sheep and gas gangrene and food poisoning in humans, is produced by all types of C. perfringens and is the major virulence determinant of C. perfringens type A.
Zishuo Guo +14 more
doaj +1 more source
Purinergic signalling: past, present and future [PDF]
, 2009 The discovery of non-adrenergic, non-cholinergic neurotransmission in the gut and bladder in the early 1960's is described as well as the identification of adenosine 5'-triphosphate (ATP) as a transmitter in these nerves in the early 1970's.
Burnstock, G
core +1 more source
P2X receptors as targets for the treatment of status epilepticus. [PDF]
, 2013 Prolonged seizures are amongst the most common neurological emergencies. Status epilepticus is a state of continuous seizures that is life-threatening and prompt termination of status epilepticus is critical to protect the brain from permanent damage ...
Diaz-Hernandez, Miguel +3 more
core +1 more source
British Journal of Pharmacology, Volume 183, Issue 3, Page 545-559, February 2026.Background and Purpose The functional organization of corneal cold nerve endings, critical structures in maintaining the ocular surface, remains poorly understood. Here, the photoisomerizable small‐molecule diethylamine‐azobenzene‐quaternary ammonium (DENAQ) was used to photomodulate activity of cold‐sensing nerve terminals in control and chronic tear ...
David Ares‐Suárez +11 more
wiley +1 more source
Effects of NAD at purine receptors in isolated blood vessels [PDF]
, 2014 Nicotinamide adenine dinucleotide (NAD) belongs to the family of naturally occurring adenine dinucleotides, best known for their various intracellular roles.
Alefishat, Eman +2 more
core +2 more sources
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source
P2 purinoceptors signaling in fibroblasts of rat subcutaneous tissue [PDF]
, 2011 Mestrado em Biologia Molecular e CelularO tecido conjuntivo parece estar envolvido na génese de diversas condições patológicas. O aumento da rigidez do tecido conjuntivo, resultante da fibrose, pode constituir um factor importante no mecanismo patogénico
Reis, Carla Patrícia da Silva e Sousa
core +1 more source