Results 61 to 70 of about 7,481 (163)
P2X7R modulation of visually evoked synaptic responses in the retina. [PDF]
, 2016 P2X7Rs are distributed throughout all layers of the retina, and thus, their localisation on various cell types puts into question their specific site(s) of action.
Chavda, S, Luthert, PJ, Salt, TE
core +1 more source
Mechanism and role of regulated cell death in tumor immunity and immunotherapy
Cancer Communications, Volume 45, Issue 11, Page 1456-1495, November 2025.Abstract Cancer immune checkpoint inhibitors (ICIs) have brought breakthroughs, but only about one‐third of cancer patients benefit from ICIs. In recent years, targeting non‐apoptotic regulated cell death (RCD) subtypes, such as ferroptosis, necroptosis, autophagy, cuproptosis, and pyroptosis, has emerged as a novel strategy in cancer therapy due to ...
Jingwen Hu +4 more
wiley +1 more source
Purinergic mechanisms in neuroinflammation: An update from molecules to behavior. [PDF]
, 2015 The principle functions of neuroinflammation are to limit tissue damage and promote tissue repair in response to pathogens or injury. While neuroinflammation has utility, pathophysiological inflammatory responses, to some extent, underlie almost all ...
Beamer, Edward +6 more
core +1 more source
CNS Neuroscience &Therapeutics, Volume 31, Issue 11, November 2025.Both pharmacological blockade and genetic knockdown of astrocytic connexin43 channels in the preBötzinger complex induce a high‐frequency breathing pattern, thereby enhancing respiratory motor output. This effect is mediated by astrocytic activation and subsequent ATP release, which activates P2Y1 receptors on somatostatin‐expressing preBötzinger ...
Xue Zhao +11 more
wiley +1 more source
Isolation and characterization of Pisum sativum apyrases, PsNTP9 and PsNTP9-DM, cloned and expressed in Escherichia coli [PDF]
, 2019 Adenosine triphosphate (ATP) is widely known as a fuel source for many biochemical processes, and to a lesser degree also as a signaling molecule in plants and animals.
Wallen, Michael Andrew, Jr
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Advanced Science, Volume 12, Issue 40, October 27, 2025.ENTPD5‐mediated conversion of extracellular adenosine triphosphate to ADP of hepatocytes is critical for maintaining hepatic glucose/lipid metabolism and promoting brown adipose tissue thermogenesis via the inhibition of adrenomedullin expression and secretion.
Rufeng Ma +9 more
wiley +1 more source
New Therapeutic Targets for Mood Disorders [PDF]
, 2010 Existing pharmacological treatments for bipolar disorder (BPD) and major depressive disorder (MDD) are often insufficient for many patients. Here we describe a number of targets/compounds that clinical and preclinical studies suggest could result in ...
Carlos A. Zarate +8 more
core +1 more source
From Genome to Geroscience: How DNA Damage Shapes Systemic Decline
BioEssays, Volume 47, Issue 10, October 2025.Persistent DNA damage triggers systemic secretory responses including damage‐associated molecular patterns (DAMPs), the senescence‐associated secretory phenotype (SASP), and extracellular vesicles (EVs). This non‐cell‐autonomous signaling disrupts intercellular communication, driving organism‐wide dysfunction and aging, and offering new therapeutic ...
Athanasios Siametis, George A. Garinis
wiley +1 more source
Dinucleoside polyphosphates : newly detected uraemic compounds with an impact on leucocyte oxidative burst [PDF]
, 2009 Background. Dinucleoside polyphosphates (NpnN) have pathophysiologic roles in cardiovascular disease and are newly detected uraemic retention solutes. They were retrieved in human plasma, tissues and cells.
Dhondt, Annemieke +5 more
core +1 more source
TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP [PDF]
, 2009 Transient receptor potential V3 (TRPV3) and TRPV4 are heat-activated cation channels expressed in keratinocytes. It has been proposed that heat-activation of TRPV3 and/or TRPV4 in the skin may release diffusible molecules which would then activate ...
Ardem Patapoutian +9 more
core +2 more sources