Results 51 to 60 of about 1,391,718 (154)
The Journal of Physiology, EarlyView.Abstract figure legend A preclinical large‐animal model of hypertensive heart failure with preserved ejection fraction (HFpEF) was used to examine the role of purinergic P2X3 receptor signalling during treadmill exercise. Animals were instrumented with either thoracic cardiac output and coronary flow probes or abdominal renal and hindlimb blood flow ...
Mridula Pachen +7 more
wiley +1 more source
Purinergic signalling: past, present and future [PDF]
, 2009 The discovery of non-adrenergic, non-cholinergic neurotransmission in the gut and bladder in the early 1960's is described as well as the identification of adenosine 5'-triphosphate (ATP) as a transmitter in these nerves in the early 1970's.
G. Burnstock, Burnstock, G
core
European Journal of Immunology, Volume 56, Issue 10, October 2026.On tumour‐reactive CD8+ TILs, CD39 drives two opposing fates at once: It marks cells actively cytolysing tumour cells via released ATP, yet also degrades that same ATP into adenosine, triggering A2AR signalling that locks the cells into a hypoxia‐amplified, self‐reinforcing immunosuppressive loop, blunting their own anti‐tumour action.
Manolo Sambucci +7 more
wiley +1 more source
Graph neural networks-based prediction of drug gene association of P2X receptors in periodontal pain
Journal of Oral Biology and Craniofacial ResearchThe P2X7 receptor, a member of the P2X receptor family, plays a crucial role in various physiological processes, particularly pain perception. Its expression across immune, neuronal, and glial cells facilitates the release of pro-inflammatory molecules ...
Pradeep Kumar Yadalam +3 more
doaj +1 more source
Small Molecule Therapeutic Approaches With a Greater Focus on Hearing Loss: A Review
Health Science Reports, Volume 9, Issue 10, October 2026.ABSTRACT Background and Aims Hearing loss (HL) is one of the most common sensory impairments worldwide and has substantial effects on quality of life and daily functioning. Although cochlear implants and hearing aids have markedly improved the management of hearing impairment, these devices do not directly address the underlying pathogenic mechanisms ...
Maryam Naghinejad +5 more
wiley +1 more source
Molecular PainToothache is one of the most common types of pain, but the mechanisms underlying pulpitis-induced pain remain unknown. The ionotropic purinergic receptor family (P2X) is reported to mediate nociception in the nervous system.
Yangxi Chen +5 more
doaj +1 more source
Role of ion channels in the pathogenesis of psoriasis
Pifu-xingbing zhenliaoxue zazhiPsoriasis is a chronic inflammatory disease involving immune dysregulation, abnormal proliferation of keratinocytes(KCs), and neurogenic inflammation, with its molecular mechanisms not yet fully elucidated.
TANG Zijie, LI Chengxin, WANG Rui
doaj +1 more source
Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach
Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley +1 more source
Neuropathic Pain: From Mechanisms to Therapeutic Interventions
MedComm, Volume 7, Issue 10, October 2026.Neuropathic pain arises from peripheral nerve injury, central sensitization, neurotransmitter imbalance, neuroimmune activation, and maladaptive circuit remodeling. Clinical phenotyping and multimodal imaging can identify dominant peripheral and central mechanisms.
Yaling Dai +8 more
wiley +1 more source
Purinergic Signaling: Impact of GPCR Structures on Rational Drug Design [PDF]
, 2020 The purinergic signaling system includes membrane-bound receptors for extracellular purines and pyrimidines, and enzymes/transporters that regulate receptor activation by endogenous agonists.
Veronica Salmaso +3 more
core +1 more source