Results 91 to 100 of about 44,347 (208)
Purinergic receptors in the endocrine and exocrine pancreas [PDF]
Purinergic Signalling, 2007 The pancreas is a complex gland performing both endocrine and exocrine functions. In recent years there has been increasing evidence that both endocrine and exocrine cells possess purinergic receptors, which influence processes such as insulin secretion and epithelial ion transport. Most commonly, these processes have been viewed separately.
openaire +4 more sources
The Journal of Physiology, EarlyView.Abstract figure legend The volume‐regulated anion channel (VRAC), composed of leucine‐rich repeat‐containing 8 (LRRC8) proteins, serves both canonical and non‐canonical functions in vertebrate cells. The canonical function of this channel relates to its original description, which is homeostatic regulation of cell volume in response to hypotonic ...
Sergei Yanushkevich +9 more
wiley +1 more source
Dual role for pannexin 1 at synapses: regulating functional and morphological plasticity
The Journal of Physiology, EarlyView.Abstract figure legend Pannexin 1 (PANX1) regulation of dendritic spines. The postnatal decrease in PANX1 expression could release key spine cytoskeleton‐regulating proteins enabling spine stabilization. Does the physiological decrease in neuronal PANX1 levels across brain development underlie dendritic spine maturation?
Adriana Casillas Martinez +3 more
wiley +1 more source
The role of purinergic receptors in neural repair and regeneration after spinal cord injury. [PDF]
Neural Regen Res, 2023 Cheng RD, Ren W, Luo BY, Ye XM.
europepmc +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The majority of L4–L5 dorsal root ganglion cells innervating the triceps surae muscles of healthy rats expressed TRPC6 channels. In decerebrated rats, pharmacological inhibition of TRPC6 channels by injection of antagonists (SAR7334 or BI‐749327) into the arterial supply of the triceps surae muscles inhibited the exercise pressor
Guillaume P. Ducrocq +5 more
wiley +1 more source
The role of Pannexin-1 channels, ATP, and purinergic receptors in the pathogenesis of HIV and SARS-CoV-2. [PDF]
Curr Opin Pharmacol, 2023 Hernandez CA, Eugenin EA.
europepmc +1 more source
Voiding Behavior and Efferent Bladder Function Altered in Mice Following Social Defeat but Not Witness Trauma [PDF]
, 2020 Chess-Williams, Russ +3 more
core +1 more source
Sphingosine‐1‐phosphate activates LRRC8 volume‐regulated anion channels through Gβγ signalling
The Journal of Physiology, EarlyView.Abstract figure legend Sphingosine‐1‐phosphate (S1P) binds to Gi protein‐coupled receptor S1PR1. Upon S1PR1 activation, Gβγ is released from the Gαi‐Gβγ heterotrimer, allowing it to recruit phospholipase Cβ (PLCβ) to the plasma membrane. PLCβ cleaves phosphatidylinositol‐4,5‐bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG).
Yulia Kostritskaia +4 more
wiley +1 more source
Structural insights into signal transduction of the purinergic receptors P2Y1R and P2Y12R. [PDF]
Protein Cell, 2023 Li B +8 more
europepmc +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Epidemiological evidence suggests a link between dementia and cardiovascular health, including the regulation of platelets. To investigate this relationship, we examined how platelet reactivity relates to cerebral neurovascular function and systemic vascular reactivity in healthy older adults.
Gabriella M. K. Rossetti +10 more
wiley +1 more source