Results 121 to 130 of about 44,347 (208)

Purinergic Receptors in the Airways: Potential Therapeutic Targets for Asthma? [PDF]

Front Allergy, 2021
Thompson RJ, Sayers I, Kuokkanen K, Hall IP.   +3 more
europepmc   +1 more source

Blockade of P2X7 receptors preserves blood retinal barrier integrity by modulating the plasmalemma vesicle‐associated protein: Implications for diabetic retinopathy

British Journal of Pharmacology, Volume 182, Issue 12, Page 2603-2620, June 2025.
Background and Purpose Plasmalemma vesicle‐associated protein (PLVAP) regulates transcytosis in vascular endothelial cells. PLVAP expression is increased in pathological conditions, such as diabetic retinopathy. P2X7 receptor antagonists have been shown to preserve blood‐retinal barrier (BRB) integrity.
Chiara Bianca Maria Platania, Francesca Lazzara, Kenneth Mitton, Naomi Haque, Wendelin Dailey, Federica Conti, Erika Giuffrida, Filippo Drago, Anca Hermenean, Cornel Balta, Hildegard Herman, Alina Ciceu, Maria Consiglia Trotta, Michele D'Amico, Giuseppe Nicosia, Settimio Rossi, Claudio Bucolo   +16 more
wiley   +1 more source

P2X4 purinergic receptors offer a therapeutic target for aggressive prostate cancer. [PDF]

J Pathol, 2022
Maynard JP, Lu J, Vidal I, Hicks J, Mummert L, Ali T, Kempski R, Carter AM, Sosa RY, Peiffer LB, Joshu CE, Lotan TL, De Marzo AM, Sfanos KS.   +13 more
europepmc   +1 more source

Neural Metabolic Networks: Key Elements of Healthy Brain Function

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
This review originated from the Fourth International Society for Neurochemistry (ISN) and Journal of Neurochemistry (JNC) Flagship School (2022). Here, we describe how the specific bioenergetic profiles and metabolic exchanges between brain cells enable and gate synaptic function and behavior. Then, based on this analysis, we discuss the potential role
Nimrod Madrer, Nirma D. Perera, Nonthué A. Uccelli, Alice Abbondanza, Jens V. Andersen, Emma Veronica Carsana, Matthew D. Demmings, Regina F. Fernandez, Matheus Garcia de Fragas, Ismail Gbadamosi, Divita Kulshrestha, Ricardo A. S. Lima‐Filho, Oana C. Marian, Kia H. Markussen, Andrew J. McGovern, Elliott S. Neal, Sukanya Sarkar, Eva Šimončičová, Jazmín Soto‐Verdugo, Sozerko Yandiev, Ignacio Fernández‐Moncada   +20 more
wiley   +1 more source

P2X Purinergic Receptors Are Multisensory Detectors for Micro-Environmental Stimuli That Control Migration of Tumoral Endothelium. [PDF]

Cancers (Basel), 2022
Scarpellino G, Genova T, Quarta E, Distasi C, Dionisi M, Fiorio Pla A, Munaron L.   +6 more
europepmc   +1 more source

Enhanced Adenosine Triphosphate Release From the Urothelium of Patients With Painful Bladder Syndrome:A Possible Pathophysiological Explanation [PDF]

, 2007
Chapple, Christopher R., Chess-Williams, Russell, Kumar, Vivek, Surprenant, Ann Marie   +3 more
core   +1 more source

Diet‐Induced Obesity Blunts Sensitivity of Intestinal Enteric Neurons: FIRST Evidence of Modulation of Activity of Enteric Neurons by Luminal Nutrients

The FASEB Journal, Volume 39, Issue 9, 15 May 2025.
The enteric nervous system (ENS) regulates critical physiological functions including gut motility, blood flow, and epithelial secretions. However, given the anatomical disadvantage of not contacting the lumen, its role in direct luminal sensing has been precluded.
Ava Grandberry, Naomi Rajesh, Robert Murphy, Sinju Sundaresan   +3 more
wiley   +1 more source

Molecular and Pharmacological Evidence for the Expression of Multiple Functional P2 Purinergic Receptors in Human Adipocytes. [PDF]

Molecules, 2022
Rossato M, Favaretto F, Granzotto M, Crescenzi M, Boscaro A, Di Vincenzo A, Capone F, Dalla Nora E, Zabeo E, Vettor R.   +9 more
europepmc   +1 more source

Adipocyte purinergic receptors activated by uracil nucleotides as obesity and type 2 diabetes targets. [PDF]

Curr Opin Pharmacol, 2022
Jain S, Jacobson KA.
europepmc   +1 more source

Control of Macrophage Inflammation by P2Y Purinergic Receptors. [PDF]

Cells, 2021
Klaver D, Thurnher M.
europepmc   +1 more source