Results 141 to 150 of about 35,200 (254)
The FASEB Journal, Volume 40, Issue 11, 15 June 2026.Bitter taste receptors (T2Rs) play an important role in physiological and cellular responses. Bitter tasting chemicals and microbial metabolites can bind to T2R14, which enables interactions between T2R14 and specific intracellular domains of the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel.
Tejas Gupte +8 more
wiley +1 more source
P2X₃ Knock-Out Mice Reveal a Major Sensory Role for Urothelially Released ATP
, 2001 The present study explores the possible involvement of a purinergic mechanism in mechanosensory transduction in the bladder using P2X₃ receptor knock-out (P2X₃ ⁻⁄⁻) and wild-type control (P2X₃ ⁺⁄⁺) mice.
Bodin, P +7 more
core
The role of Pannexin-1 channels, ATP, and purinergic receptors in the pathogenesis of HIV and SARS-CoV-2. [PDF]
Curr Opin Pharmacol, 2023 Hernandez CA, Eugenin EA.
europepmc +1 more source
Purinergic receptors in the endocrine and exocrine pancreas
, 2007 Udgivelsesdato: 2007-Dec-11The pancreas is a complex gland performing both endocrine and exocrine functions. In recent years there has been increasing evidence that both endocrine and exocrine cells possess purinergic receptors, which influence ...
Novak, I, I. Novak
core +1 more source
Channel Dysfunction as the Basis for Comorbidities in Multiple Sclerosis and Depression
Archiv der Pharmazie, Volume 359, Issue 6, June 2026.Ion channel remodelling induced by neuroinflammation in multiple sclerosis alters neuronal excitability and immune signalling, creating shared molecular pathways that link multiple sclerosis pathology to depression and reveal novel pharmacological targets.
Nicole Rychlik +4 more
wiley +1 more source
Caffeine and Headache: Exploring the Multifaceted Relationship
Brain and Behavior, Volume 16, Issue 6, June 2026.ABSTRACT Purpose To explore the multifaceted relationship between caffeine and headache disorders, focusing on its dual role as both an analgesic and a potential trigger and to summarize the mechanisms underlying its anti‐nociceptive effects. Method This narrative review synthesizes evidence from experimental, clinical, and epidemiological studies on ...
Mona Hussein +6 more
wiley +1 more source
Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.Abstract Atrial fibrillation (AF), the most common clinical arrhythmia, is driven by inflammatory activation and oxidative stress, though precise molecular links remain unclear. This study identifies the P2X7 receptor as a key upstream regulator orchestrating proarrhythmic atrial remodeling through reactive oxygen species (ROS)‐mediated mitogen ...
Lingnan Zhang, Yeran Zhu, Xinshun Gu
wiley +1 more source
Targeting purinergic receptors to attenuate inflammation of dry eye. [PDF]
Purinergic Signal, 2023 Wang JN, Fan H, Song JT.
europepmc +1 more source
Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1494-1502, June 2026.Carfilzomib is highly effective in the treatment of multiple myeloma, but it has been associated with cardiovascular adverse events that impact patient outcomes. Our prior global metabolomic analyses indicated an association between hydrophilic bile acids and carfilzomib‐cardiotoxicity risk, although a causal relationship remained to be determined ...
Samia Shabnaz +15 more
wiley +1 more source
The Role of ATP and Purinergic Receptors in Taste Signaling. [PDF]
Handb Exp Pharmacol, 2022 Kinnamon S, Finger T.
europepmc +1 more source