Results 161 to 170 of about 51,246 (252)

The multifaceted roles of the transcription factor SP1 in the pathogenesis of Alzheimer's disease: From molecular regulation to therapeutic targets

open access: yesAlzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 2, April/June 2026.
Abstract Alzheimer's disease (AD) is driven by interrelated pathologies, including the accumulation of amyloid β (Aβ), tau pathology, chronic neuroinflammation, and oxidative stress (OS). These pathological processes collectively lead to progressive neurodegeneration.
Zhengxiang Lv   +5 more
wiley   +1 more source

Molecular and Pharmacological Evidence for the Expression of Multiple Functional P2 Purinergic Receptors in Human Adipocytes. [PDF]

open access: yesMolecules, 2022
Rossato M   +9 more
europepmc   +1 more source

pH‐Dependent Microenvironmental Ionic Signaling in Pancreatic Ductal Adenocarcinoma

open access: yesActa Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Pancreatic ductal adenocarcinoma (PDAC) develops within a uniquely dynamic pH landscape shaped by substantial acid–base fluxes produced by the exocrine pancreas. Secretion of alkaline pancreatic juice, normally linked to digestion, produces intermittent acidifications of the pancreatic interstitium, which challenges epithelial and stromal ...
Albrecht Schwab   +37 more
wiley   +1 more source

Blocking microglial reactivity via purinergic receptors prevents subacute cognitive deficits after TIA. [PDF]

open access: yesEMBO Mol Med
Llovera G   +12 more
europepmc   +1 more source

Intramuscular neutrophil‐derived immunometabolic niches locally boost insulin‐responsive GLUT4 translocation after muscle contraction

open access: yesThe Journal of Physiology, Volume 604, Issue 7, Page 2717-2737, 1 April 2026.
Abstract figure legend Contraction‐induced formation of a NET‐based immunometabolic niche potentiates regional insulin sensitivity and GLUT4 translocation. The schematic model illustrating how skeletal muscle contraction promotes a NET‐based immunometabolic niche that enhances regional insulin sensitivity.
Weijian Chen, Makoto Kanzaki
wiley   +1 more source

P2X Purinergic Receptors Are Multisensory Detectors for Micro-Environmental Stimuli That Control Migration of Tumoral Endothelium. [PDF]

open access: yesCancers (Basel), 2022
Scarpellino G   +6 more
europepmc   +1 more source

The role of purinergic signalling in the musculoskeletal system [PDF]

open access: yes
Abbracchio   +176 more
core   +1 more source

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