Results 151 to 160 of about 32,402 (193)
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Current Opinion in Pharmacology, 2003
Activation of P2Y(1) and P2Y(12) receptors, through secreted ADP that is stimulated by agonists such as thrombin, thromboxane and collagen, is a major mechanism of platelet activation. P2X(1) receptors also participate in platelet shape change and potentiation of calcium mobilization.
Satya P, Kunapuli +3 more
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Activation of P2Y(1) and P2Y(12) receptors, through secreted ADP that is stimulated by agonists such as thrombin, thromboxane and collagen, is a major mechanism of platelet activation. P2X(1) receptors also participate in platelet shape change and potentiation of calcium mobilization.
Satya P, Kunapuli +3 more
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Annals of the New York Academy of Sciences, 1990
In rabbits the contractile response of the urinary bladder is only partially due to cholinergic innervation since atropine does not completely block neuronally mediated contractions. In the human bladder this atropine resistance is controversial with some reporting atropine resistance in vitro while others have stated that the atropine resistance is ...
M R, Ruggieri, K E, Whitmore, R M, Levin
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In rabbits the contractile response of the urinary bladder is only partially due to cholinergic innervation since atropine does not completely block neuronally mediated contractions. In the human bladder this atropine resistance is controversial with some reporting atropine resistance in vitro while others have stated that the atropine resistance is ...
M R, Ruggieri, K E, Whitmore, R M, Levin
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Signaling at Purinergic P2X Receptors
Annual Review of Physiology, 2009P2X receptors are membrane cation channels gated by extracellular ATP. Seven P2X receptor subunits (P2X1-7) are widely distributed in excitable and nonexcitable cells of vertebrates. They play key roles in inter alia afferent signaling (including pain), regulation of renal blood flow, vascular endothelium, and inflammatory responses.
Surprenant, Annmarie, Alan North, R.
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Purinergic receptors, prostacyclin and atherosclerosis
Pharmacological Research, 1992Over the last decade, evidence has been provided that endothelial cells have a metabolic function in order to maintain blood vessel homeostasis. The endothelium releases relaxing and contracting factors in response to endogenous or exogenous substances such as acetylcholine, calcimycine, adenosine 5'triphosphate (ATP), bradykinin, arachidonic acid and ...
RAGAZZI, EUGENIO, CHINELLATO A.
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Purinergic and Glutamatergic Receptors on Astroglia
2014Astroglial cells express many neurotransmitter receptors; the receptors to glutamate and ATP being the most abundant. Here, we provide a concise overview on the expression and main properties of astroglial glutamate receptors (ionotropic receptors represented by AMPA and NMDA subtypes) and metabotropic (mainly mGluR5 and mGluR3 subtypes) and ...
Verkhratsky, A; id_orcid 0000-0003-2592-9898 +1 more
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Current Pharmaceutical Design, 2009
There is a brief summary of the early background literature about purinergic signalling and its involvement in pain, of ATP storage, release and ectoenzymatic breakdown and of the current classification of receptor subtypes for purines and pyrimidines. The review then focuses on purinergic mechanosensory transduction involved in visceral, cutaneous and
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There is a brief summary of the early background literature about purinergic signalling and its involvement in pain, of ATP storage, release and ectoenzymatic breakdown and of the current classification of receptor subtypes for purines and pyrimidines. The review then focuses on purinergic mechanosensory transduction involved in visceral, cutaneous and
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2002
Abstract The term purinergic receptor (or purinoceptor ) was first introduced to describe classes of membrane receptors that, when activated by either neurally released ATP (P2 purinoceptor ) or its breakdown product adenosine (P1 purinoceptor ), mediated relaxation of gut smooth muscle (Burnstock 1972, 1978).
Brian F King, Geoffrey Burnstock
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Abstract The term purinergic receptor (or purinoceptor ) was first introduced to describe classes of membrane receptors that, when activated by either neurally released ATP (P2 purinoceptor ) or its breakdown product adenosine (P1 purinoceptor ), mediated relaxation of gut smooth muscle (Burnstock 1972, 1978).
Brian F King, Geoffrey Burnstock
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PET Imaging of Purinergic Receptors
2020Over the recent years, interest in the purinergic signaling system has sparked in the field of positron emission tomography (PET). Purinergic receptors play key roles in physiological and pathological processes, although the exact role in these processes is not always fully understood.
Janssen, Bieneke +2 more
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Agonists and Antagonists for Purinergic Receptors
2019Membrane receptors that are activated by the purine nucleoside adenosine (adenosine receptors) or by purine or pyrimidine nucleotides (P2Y and P2X receptors) transduce extracellular signals to the cytosol. They play important roles in physiology and disease. The G protein-coupled adenosine receptors comprise four subtypes: A1, A2A, A2B, and A3.
Christa E, Müller +2 more
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Purinergic receptors in gastrointestinal inflammation
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2008Purinergic receptors comprise a family of transmembrane receptors that are activated by extracellular nucleosides and nucleotides. The two major classes of purinergic receptors, P1 and P2, are expressed widely in the gastrointestinal tract as well as immune cells.
Vasantha L, Kolachala +3 more
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