Results 151 to 160 of about 35,200 (254)

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
wiley   +1 more source

A Dynamic Change of Microglial States Occurs During the Transition From Photoreceptor Degeneration to Regeneration in Zebrafish pde6c Mutants

Glia, Volume 74, Issue 6, June 2026.
Zebrafish pde6c mutants undergo photoreceptor degeneration from 5 dpf, but rods regenerate from 4 wpf. scRNA‐seq of retinal microglia reveals dynamic change of states between 5 dpf and 4 wpf. Two states emerge specifically during regeneration. ABSTRACT Microglia, brain‐resident immune cells, maintain brain homeostasis.
Darshini Ravishankar, Yuki Takeuchi, Ichiro Masai   +2 more
wiley   +1 more source

Purinergic receptors of mice podocytes in culture

, 2003
Extrazelluläre Nukleotide wie ATP und UTP sind wichtige Regulatoren glomerulärer Funktionen. In der vorliegenden Arbeit wurde die Reaktion von kultivierten Mauspodozyten auf purinenerge Agonisten mit der Saug-Elektroden Technik und intrazellulärer Ca2 ...
Saueressig, Ulrich
core  

Nucleotide homeostasis and purinergic nociceptive signaling in rat meninges in migraine-like conditions

, 2020
© 2016, Springer Science+Business Media Dordrecht.Extracellular ATP is suspected to contribute to migraine pain but regulatory mechanisms controlling pro-nociceptive purinergic mechanisms in the meninges remain unknown.
Yegutkin G., Koroleva K., Kilinc E., Ishchenko Y., Giniatullin R., Abushik P., Fayuk D., Giniatullina R., Guerrero-Toro C.   +8 more
core  

Purinergic receptors mediate endothelial dysfunction and participate in atherosclerosis. [PDF]

Purinergic Signal, 2023
Wu XM, Zhang N, Li JS, Yang ZH, Huang XL, Yang XF.   +5 more
europepmc   +1 more source

Anti-Inflammatory Activity of 1,4-Naphthoquinones Blocking P2X7 Purinergic Receptors in RAW 264.7 Macrophage Cells. [PDF]

Toxins (Basel), 2023
Kozlovskiy SA, Pislyagin EA, Menchinskaya ES, Chingizova EA, Sabutski YE, Polonik SG, Likhatskaya GN, Aminin DL.   +7 more
europepmc   +1 more source

Cannabidiol Protects Against 1‐Methyl‐4‐Phenylpyridinium and Manganese‐Induced Neurotoxicity via Nod‐Like Receptor Protein 3 Inflammasome Suppression

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
CBD oil exhibits neuroprotective effects in Parkinson's disease models by inhibiting NLRP3 inflammasome activation. It preserves dopamine levels and reduces α‐synuclein accumulation, suggesting its potential as a therapeutic strategy against neuroinflammation and neurodegeneration.
Göksun Demirel, Anıl Yirün, Deniz Arca Çakir, Hüseyin Özkan, Berfu Şura Güneş, Selen Selvi, Yeter EROL. Öztürk, Pınar Erkekoğlu   +7 more
wiley   +1 more source

Purinergic Receptors P2X7 and P2X4 as Markers of Disease Progression in the rd10 Mouse Model of Inherited Retinal Dystrophy. [PDF]

Int J Mol Sci, 2022
Martínez-Gil N, Kutsyr O, Noailles A, Fernández-Sánchez L, Vidal L, Sánchez-Sáez X, Sánchez-Castillo C, Lax P, Cuenca N, García AG, Maneu V.   +10 more
europepmc   +1 more source

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source

Encephalopathy: Cause, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 6, June 2026.
Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv, Xia Zhong, Ruirui Shang, Linghui Kong, Yufei Huang, Yuexiang Ma, Jing Teng, Sheng Wei   +7 more
wiley   +1 more source