Results 151 to 160 of about 51,246 (252)
Enhanced Adenosine Triphosphate Release From the Urothelium of Patients With Painful Bladder Syndrome:A Possible Pathophysiological Explanation [PDF]
, 2007 Chapple, Christopher R. +3 more
core +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.EA exerts therapeutic effects in ischemic stroke through multiple mechanisms: it alleviates acute injury by suppressing neuroinflammation, excitotoxicity, oxidative stress, apoptosis, pyroptosis, ferroptosis, autophagy dysregulation, and blood–brain barrier disruption, while enhancing cerebral blood flow, angiogenesis, and neurogenesis to support ...
Mingyue Zhao +8 more
wiley +1 more source
Anti-Inflammatory Activity of 1,4-Naphthoquinones Blocking P2X7 Purinergic Receptors in RAW 264.7 Macrophage Cells. [PDF]
Toxins (Basel), 2023 Kozlovskiy SA +7 more
europepmc +1 more source
Comprehensive Physiology, Volume 16, Issue 2, April 2026.Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu +11 more
wiley +1 more source
Purinergic Receptors P2X7 and P2X4 as Markers of Disease Progression in the rd10 Mouse Model of Inherited Retinal Dystrophy. [PDF]
Int J Mol Sci, 2022 Martínez-Gil N +10 more
europepmc +1 more source
Protective Effect of Silymarin Against Paclitaxel‐Induced Cardiotoxicity
Food Science &Nutrition, Volume 14, Issue 4, April 2026.Paclitaxel, a potent chemotherapeutic agent, induces oxidative stress, inflammation, and apoptosis leading to cardiotoxicity. In this study, silymarin supplementation significantly reduced oxidative stress markers, downregulated inflammatory cytokines (IL‐1β, TNF‐α, NF‐κB), and restored the balance between pro‐ and anti‐apoptotic proteins in rat heart ...
Tuğçe Tutar +4 more
wiley +1 more source
Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment
MedComm, Volume 7, Issue 4, April 2026.Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai +3 more
wiley +1 more source
P2X4 purinergic receptors offer a therapeutic target for aggressive prostate cancer. [PDF]
J Pathol, 2022 Maynard JP +13 more
europepmc +1 more source
Pharmacological Separation of Mechanosensory Mechanisms in Rat Urinary Bladder Ex Vivo
Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.ABSTRACT The local response of the bladder wall to stretch is believed to result from the coordinated activation of mechanosensitive ion channels located in the plasma membrane of the cells that form the wall's urothelial and detrusor smooth muscle (DSM) layers.
Igor B. Philyppov +4 more
wiley +1 more source