Results 181 to 190 of about 35,200 (254)

Asymptomatic Versus Symptomatic Alzheimer's Disease Neuropathology: A Systematic Review of Differences Reported in Post‐Mortem Studies

Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.
Graphical summary of post‐mortem brain tissue findings that differ between symptomatic and asymptomatic AD. Current evidence suggests reduced accumulation of Aβ and p‐tau oligomers, particularly at synapses, preserved neuronal and synaptic integrity and metabolic activity and a dynamic profile of glial and immune responses in ASYMAD.
Thiago Guilherme Rêgo Barros, Laura Barbosa Grossi, Maria Letícia da Silva Campos, Israel Bem‐Hur Netto Cardoso, Antônio Lúcio Teixeira, Aline Silva de Miranda, Eliana Cristina de Brito Toscano   +6 more
wiley   +1 more source

Pannexin-1 channels, extracellular ATP, and purinergic receptors are essential for CCR5/CXCR4 clustering and HIV entry. [PDF]

NeuroImmune Pharm Ther
Ajasin D, Velasquez S, Gibson J, Scemes E, Cibelli A, Spray D, Eugenin EA.   +6 more
europepmc   +1 more source

Early Regional Microglial Remodelling in the Hippocampus of the AppNL‐G‐F Alzheimer's Model

Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.
Microglia undergo profound structural and functional changes during Alzheimer's disease, yet the earliest stages of morphological remodelling that occur prior to amyloid deposition remain poorly defined. Through high‐resolution 3D morphometry in the CA1 region of the hippocampus of AppNL‐G‐F mice, it was found that although microglial numbers and ...
Ryan J. Bevan, Jessica F. Minett, Alice L. Smith, Ana Cardus Figueras, Philip R. Taylor   +4 more
wiley   +1 more source

The genetic inhibition of GPR17 affects myelination by influencing important players in oligodendrocyte maturation, including purinergic receptors

, 2017
Oligodendrocyte precursor cells (OPCs) are the primary source of myelinating oligodendrocytes in the central nervous system (CNS). Both OPCs and mature oligodendrocytes express purinergic receptors, and for some of them, their expression is restricted to
Fumagalli M, Marangon D, Coppolino GT, Lecca D, Abbracchio MP., Bonfanti E   +5 more
core  

Purines and purinergic receptors in primary tumors of the central nervous system. [PDF]

Purinergic Signal
Soares AA, Dos Santos HM, Domann KN, Alves NPR, Böhm BR, Haack CM, Pretto KP, Guimarães ES, Rocha GF, de Paula IR, de Alcântara Guimarães LE, de Ávila Pessoa HC, Rodrigues RD, Dalagnol AMK, da Cunha MLV, de Resende E Silva DT.   +15 more
europepmc   +1 more source

Aerobic Exercise Inhibited P2X7 Purinergic Receptors to Improve Cardiac Remodeling in Mice With Type 2 Diabetes. [PDF]

Front Physiol, 2022
Wang T, Li J, Li H, Zhong X, Wang L, Zhao S, Liu X, Huang Z, Wang Y.   +8 more
europepmc   +1 more source

Acute Sleep Deprivation Shifts Substrate Utilization Toward Greater Fat Oxidation During Incremental Exercise in Recreationally Trained Adults

Scandinavian Journal of Medicine &Science in Sports, Volume 36, Issue 6, June 2026.
ABSTRACT Sleep deprivation alters metabolic homeostasis and substrate metabolism, but its effect on fat and carbohydrate utilization during exercise is unclear. This study examined the effects of one night of total and partial sleep deprivation on substrate utilization during a maximal fat oxidation test (MFO) in recreationally trained adults.
Marta del Val‐Manzano, Juan Jesús Montalvo‐Alonso, Paola Gonzalo‐Encabo, David Valadés, Carmen Ferragut, Alberto Pérez‐López   +5 more
wiley   +1 more source

Platelets, inflammation, and purinergic receptors in chronic kidney disease. [PDF]

Kidney Int
Corken AL, Ong V, Kore R, Ghanta SN, Karaduta O, Pathak R, Rose S, Porter C, Jain N.   +8 more
europepmc   +1 more source

HIF‐Regulated Pannexin‐1 Channel Drives Luminal ATP Accumulation in Kidney Cysts

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Autosomal dominant polycystic kidney disease causes progressive cyst enlargement in the kidneys, leading to hypoxia and induction of HIF‐1α. Our study identifies HIF‐1α‐dependent transcriptional upregulation of Pannexin1 (PANX1) in the apical membrane of cyst epithelial cells, promoting ATP release into the cyst lumen.
Kathrin Skoczynski, Julia Katharina Scholz, Raluca Ursu, Johannes Schödel, Steffen Grampp, Stephanie Naas, Victoria Lauer, Mario Schiffer, Maike Büttner‐Herold, Bjoern Buchholz, Andre Kraus   +10 more
wiley   +1 more source

Regulation of GABAergic neurotransmission by purinergic receptors in brain physiology and disease. [PDF]

Purinergic Signal
Juvenal G, Higa GSV, Bonfim Marques L, Tessari Zampieri T, Costa Viana FJ, Britto LR, Tang Y, Illes P, di Virgilio F, Ulrich H, de Pasquale R.   +10 more
europepmc   +1 more source