Results 141 to 150 of about 2,313,736 (322)

Aspirin-dependent effects on purinergic P2Y1 receptor express [PDF]

, 2019
Chronic treatment with aspirin in healthy volunteers (HVs) is associated with recovery of adenosine diphosphate (ADP)-induced platelet activation. The purinergic P2Y1 receptor exerts its effects via a Gq-protein, which is the same biochemical pathway ...
Alemanno, Laura, Angiolillo, Dominick J, Ceccacci, Andrea, Frati, Luigi, Guarino, Maria Luisa, Guerriero, Raffaella, Mancone, Massimo, Massimi, Isabella, Pulcinelli, Fabio M   +8 more
core   +1 more source

Targeting Purinergic Receptors in Islet Transplantation [PDF]

Diabetes, 2013
Transplanted islets are exposed to a distinctively hostile immunological environment. Grafted islets typically encounter a combination of innate, allogeneic and anti-islet immune responses—the relative contributions of which are not fully understood.
openaire   +2 more sources

Chemoreflex function in pulmonary diseases – A review

The Journal of Physiology, EarlyView.
Abstract figure legend Chemoreflex activation in respiratory diseases and COVID‐19 populations. Abstract The chemoreflex is a vital protective reflex that is crucial in restoring normal blood gas and pH levels. The carotid bodies are peripheral chemoreceptors activated by hypoxia (primarily), hypercapnia, acidaemia, temperature, lactate and potassium ...
Kajal Kamra, Zhiqiu Xia, Irving H. Zucker, Harold Schultz, Han‐Jun Wang   +4 more
wiley   +1 more source

Dinucleoside polyphosphates : newly detected uraemic compounds with an impact on leucocyte oxidative burst [PDF]

, 2009
Background. Dinucleoside polyphosphates (NpnN) have pathophysiologic roles in cardiovascular disease and are newly detected uraemic retention solutes. They were retrieved in human plasma, tissues and cells.
Dhondt, Annemieke, Glorieux, Griet, Jankowski, Joachim, Jankowski, Vera, Schepers, Eva, Vanholder, Raymond   +5 more
core   +1 more source

The glia‐immune network: Astrocytes and oligodendrocytes as microglial co‐ordinators in health and disease

The Journal of Physiology, EarlyView.
Abstract figure legend The glia‐immune network involves the communication(s) of glia via immune signalling pathways. In neuro‐homeostasis these pathways have been shown to modulate key processes such as synaptic pruning and myelination. The dynamics of these processes is critical to CNS function.
Verity F. T. Mitchener, Millie J. Thackray, I. Lorena Arancibia‐Cárcamo   +2 more
wiley   +1 more source

Identification of a carbohydrate recognition motif of purinergic receptors. [PDF]

Elife, 2023
Zhao L, Wei F, He X, Dai A, Yang D, Jiang H, Wen L, Cheng X.   +7 more
europepmc   +1 more source

Purinergic glio-endothelial coupling during neuronal activity: role of P2Y1 receptors and eNOS in functional hyperemia in the mouse somatosensory cortex.

American Journal of Physiology. Heart and Circulatory Physiology, 2015
Impairment of moment-to-moment adjustment of cerebral blood flow (CBF) via neurovascular coupling is thought to play a critical role in the genesis of cognitive impairment associated with aging and pathological conditions associated with accelerated ...
Peter Toth, Peter Toth, Stefano Tarantini, Antonio Davila, M. N. Valcarcel-Ares, Zsuzsanna Tucsek, Zsuzsanna Tucsek, Behzad Varamini, Praveen Ballabh, W. Sonntag, J. Baur, A. Csiszar, Z. Ungvari   +12 more
semanticscholar   +1 more source

Diverse Subpopulations of Reactive Astrocytes Following Chronic Toxoplasma Infection

Glia, Volume 73, Issue 10, Page 2003-2024, October 2025.
Main Points Toxoplasma infection results in distinct astrocyte subpopulations. Chronically labeled reactive astrocytes appear transcriptionally plastic and can regain acute inflammatory responding and naive homeostatic astrocytic gene patterns in the presence of ongoing neuroinflammation.
Zoe A. Figueroa, Jose L. Martin, Arzu Ulu, William Agnew‐Svoboda, Teresa Ubina, Martin M. Riccomagno, Todd A. Fiacco, Emma H. Wilson   +7 more
wiley   +1 more source

Adrenergic Control of P2Y6 Receptor‐Dependent Phagocytosis in Rodent and Human Microglia

Glia, Volume 73, Issue 10, Page 2025-2034, October 2025.
Main Points Adrenergic signaling through ADRB2 modulates phagocytosis in microglia Crosstalk between ADRB2 and P2Y6 receptors conserved in rodent and human microglia ADRB2 activation inhibits both P2Y6 function and gene expression ABSTRACT Microglia, the resident immune cells of the central nervous system (CNS), are in constant survey of their ...
Thomas Deluc, Ariel Ase, Marie‐France Dorion, Gilles Maussion, Yeman Tang, Rita T. M. Lo, Irina Shlaifer, Valerio E. Piscopo, Thomas M. Durcan, Stefano Stifani, Philippe Séguéla   +10 more
wiley   +1 more source

P2 purinoceptors signaling in fibroblasts of rat subcutaneous tissue [PDF]

, 2011
Mestrado em Biologia Molecular e CelularO tecido conjuntivo parece estar envolvido na génese de diversas condições patológicas. O aumento da rigidez do tecido conjuntivo, resultante da fibrose, pode constituir um factor importante no mecanismo patogénico
Reis, Carla Patrícia da Silva e Sousa
core   +1 more source