Results 71 to 80 of about 2,313,736 (322)

Involvement of P2Y₁, P2Y₆, A₁ and A_2A Receptors in the Purinergic Inhibition of NMDA-Evoked Noradrenaline Release in the Rat Brain Cortex

Cells, 2023
In the cerebral cortex, glutamate activates NMDA receptors (NMDARs), localized in noradrenergic neurons, inducing noradrenaline release that may have a permissive effect on glutamatergic transmission, and therefore, on the modulation of long-term ...
Clara Quintas, Jorge Gonçalves, Glória Queiroz   +2 more
doaj   +1 more source

A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

Advanced Science, EarlyView.
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao, Zhen Li, Ming‐Jie Zhao, Shu‐Ying Li, Qing Xia, Shuoyu Xu, Yu Zhang, Yi Wang, Fang Li, Yu‐Ling Liu, Yun‐Hui Guo, Ruo‐Xi Xu, Han Zhou, Hong Zhou, Wen‐Wen Ding, Yong‐Chen Wang, Yanying Miao, Zhongfeng Wang   +17 more
wiley   +1 more source

Extracellular ATP triggers proteolysis and cytosolic Ca²⁺ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites. [PDF]

, 2012
BACKGROUND: Plasmodium has a complex cell biology and it is essential to dissect the cell-signalling pathways underlying its survival within the host. METHODS: Using the fluorescence resonance energy transfer (FRET) peptide substrate Abz-AIKFFARQ-EDDnp ...
Blackman, Michael J, Budu, Alexandre, Cruz, Laura Nogueira, Garcia, Célia Rs, Holder, Anthony A, Juliano, Luiz, Juliano, Maria Aparecida   +6 more
core   +4 more sources

Purinergic signaling via P2X receptors and mechanisms of unregulated ATP release in the outer retina and age-related macular degeneration

Frontiers in Neuroscience, 2023
Age-related macular degeneration (AMD) is a chronic and progressive inflammatory disease of the retina characterized by photoceptor loss and significant central visual impairment due to either choroidal neovascularization or geographic atrophy.
Haydn Molcak, Kailun Jiang, Christopher J. Campbell, Joanne A. Matsubara   +3 more
doaj   +1 more source

Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis

Journal of Neuroinflammation, 2017
BackgroundMicroglia are major players in the pathogenesis of multiple sclerosis (MS) and may play a dual role in disease progression. The activation status of microglia in vivo is highly dynamic and occurs as a continuum, with the pro-inflammatory and ...
W. Beaino, B. Janssen, G. Kooij, Susanne M. A. van der Pol, B. J. van het Hof, J. van Horssen, A. Windhorst, H. D. de Vries   +7 more
semanticscholar   +1 more source

Bispecific Antibody Targeting VEGF/TGF‐β Synergizes with Local Radiotherapy: Turning Tumors from Cold to Inflamed and Amplifying Abscopal Effects

Advanced Science, EarlyView.
Y332D, a bispecific antibody that simultaneously blockades VEGF and TGF‐β, counteracted negative RT effects that are attributed to the upregulation of TGF‐β and VEGF, as well as further enhanced the immunostimulatory effects of RT, thereby reprograming the TME from immune “cold” to inflamed state and forming an effective in‐situ vaccine that eradicate ...
Lijuan Lyu, Ming Yi, Ji Chen, Jing Zhang, Xiaobin Ma, Xiaojun Zhang, Liang Zeng, Yan Xue, Haimei Wen, Yujiao Deng, Pengfei Zhou, Kongming Wu, Huafeng Kang, Zhijun Dai   +13 more
wiley   +1 more source

Purinergic receptors on blood platelets

Platelets, 1996
Extracellular adenine nucleotides interact with P2 purinergic receptors to regulate a broad range of physiological processes among which platelet aggregation P2 purinoceptors were divided into two main groups: the G-protein coupled receptor or 'metabotropic' superfamily termed P2Y and the ligand-gated ion channel or 'ionotropic receptor' superfamily ...
J P Cazenave, Catherine Vial, Béatrice Hechler, Christian Gachet, Catherine Léon, Philippe Ohlmann   +5 more
openaire   +3 more sources

Characterization of ionotrophic purinergic receptors in hepatocytes [PDF]

Hepatology, 2008
Ionotrophic purinergic (P2X) receptors function as receptor-gated cation channels, where agonist binding leads to opening of a nonselective cation pore permeable to both Na+ and Ca2+. Based on evidence that extracellular adenosine 5′-triphosphate (ATP) stimulates glucose release from liver ...
Gordan Kilic, Svjetlana Dolovcak, Andrew P. Feranchak, Livia Puljak, Ryan R. McWilliams, R. Brian Doctor, Bonnie C. Miller, Daniel S. Emmett, J. Gregory Fitz   +8 more
openaire   +4 more sources

Purinergic Signaling in the Pathophysiology and Treatment of Huntington’s Disease

Frontiers in Neuroscience, 2021
Huntington’s disease (HD) is a devastating, progressive, and fatal neurodegenerative disorder inherited in an autosomal dominant manner. This condition is characterized by motor dysfunction (chorea in the early stage, followed by bradykinesia, dystonia ...
Melissa Talita Wiprich, Melissa Talita Wiprich, Carla Denise Bonan, Carla Denise Bonan, Carla Denise Bonan   +4 more
doaj   +1 more source

Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation

Advanced Science, EarlyView.
This article comprehensively explores the pivotal role of mitochondrial function in CD8⁺ T cell immunotherapy. It highlights how mitochondrial dynamics regulate T cell activation, differentiation, and persistence, and how mitochondrial dysfunction leads to immune exhaustion and impaired antitumor/antiviral responses.
Xu Chen, Pei Lin, Ye Lu, Jiarong Zheng, Yunfan Lin, Zihao Zhou, Li Cui, Xinyuan Zhao   +7 more
wiley   +1 more source