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Purinergic Signalling in the Gut
2016The article will begin with the discovery of purinergic inhibitory neuromuscular transmission in the 1960s/1970s, the proposal for purinergic cotransmission in 1976 and the recognition that sympathetic nerves release adenosine 5'-triphosphate (ATP), noradrenaline and neuropeptide Y, while non-adrenergic, non-cholinergic inhibitory nerve cotransmitters ...
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Purinergic Signaling in Glioma Progression
2012Among the pathological alterations that give tumor cells invasive potential, purinergic signaling is emerging as an important component. Studies performed in in vitro, in vivo and ex vivo glioma models indicate that alterations in the purinergic signaling are involved in the progression of these tumors.
Ana Maria Oliveira Battastini +3 more
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Signaling at Purinergic P2X Receptors
Annual Review of Physiology, 2009P2X receptors are membrane cation channels gated by extracellular ATP. Seven P2X receptor subunits (P2X1-7) are widely distributed in excitable and nonexcitable cells of vertebrates. They play key roles in inter alia afferent signaling (including pain), regulation of renal blood flow, vascular endothelium, and inflammatory responses.
Surprenant, Annmarie, Alan North, R.
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Introduction to Purinergic Signalling in the Brain
2012ATP is a cotransmitter with glutamate, noradrenaline, GABA, acetylcholine and dopamine in the brain. There is a widespread presence of both adenosine (P1) and P2 nucleotide receptors in the brain on both neurons and glial cells. Adenosine receptors play a major role in presynaptic neuromodulation, while P2X ionotropic receptors are involved in fast ...
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2012
Publisher Summary Purines such as ATP and adenosine play a central role in the energy metabolism of all life forms. This fact probably delayed recognition of other roles for purines as autocrine and paracrine substances, and neurotransmitters. The principal ligands for purinergic receptors are adenosine, ATP and UTP.
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Publisher Summary Purines such as ATP and adenosine play a central role in the energy metabolism of all life forms. This fact probably delayed recognition of other roles for purines as autocrine and paracrine substances, and neurotransmitters. The principal ligands for purinergic receptors are adenosine, ATP and UTP.
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From purines to purinergic signalling: molecular functions and human diseases
Signal Transduction and Targeted Therapy, 2021Alexei Verkhratsky +2 more
exaly
History of ectonucleotidases and their role in purinergic signaling.
Biochemical Pharmacology, 2020H. Zimmermann
semanticscholar +1 more source
Purinergic receptors modulators: An emerging pharmacological tool for disease management
Medicinal Research Reviews, 2022Abid Mahmood, Jamshed Iqbal
exaly