Results 81 to 90 of about 5,354,149 (260)

Human dental pulp stem cells regulate allogeneic NK cells’ function via induction of anti‐inflammatory purinergic signalling in activated NK cells

Cell Proliferation, 2019
Mesenchymal stem cells (MSCs) could regulate the function of various immune cells. It remains unclear whether MSCs additionally possess immunostimulatory properties. We investigated the impact of human MSCs on the responsiveness of primary natural killer
Fei Yan, O. Liu, Haixia Zhang, Yueying Zhou, Dian Zhou, Zekun Zhou, Yuhong He, Zhangui Tang, Songlin Wang   +8 more
semanticscholar   +1 more source

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

Beneficial effect of electroacupuncture on the distribution of foreign substances in the brain of rats developing depression-like behavior

IBRO Neuroscience Reports, 2023
We used low and high molecular weight fluorescence tracers to investigate the entry of foreign solutes into the brain parenchyma and their exit from it by the glymphatic system, during experimentally induced depressive-like behavior in rats.
Jin-Rong He, Patrizia Rubini, Bao-Man Li, Hai-Yan Yin, Yong Tang, Peter Illes   +5 more
doaj   +1 more source

Purinergic signaling in hepatic disease [PDF]

Purinergic Signalling, 2019
Extracellular purines (ATP and adenosine) are ubiquitous intercellular messengers. During tissular damage, they function as damage-associated molecular patterns (DAMPs). In this context, purines announce tissue alterations to initiate a reparative response that involve the formation of the inflammasome complex and the recruitment of specialized cells ...
E. Velázquez-Miranda, M. Díaz-Muñoz, F. G. Vázquez-Cuevas   +2 more
openaire   +2 more sources

Dual Action of Dipyridamole in Experimental Rheumatoid Arthritis: Suppression of Joint Inflammation and Upregulation of Muscle Anabolism via Adenosine and AMPK Pathways

Arthritis &Rheumatology, EarlyView.
Objective Rheumatoid sarcopenia, characterized by the progressive loss of skeletal muscle mass and function, is a frequent comorbidity in rheumatoid arthritis (RA), linked to prolonged, severe systemic inflammation. Purinergic signaling (adenosine, AMP, and ATP) plays a crucial role in inflammation, myogenesis, and muscle hypertrophy.
Miguel Marco‐Bonilla, Maria Fresnadillo, Irene Sanchez‐Platero, Macarena de la Riva‐Bueno, Fernando Huete‐Toral, Gonzalo Carracedo, Carmen Conde, Yolanda Benitez, Pablo Minguez, Sandra Carolina Cifuentes, Joaquin Rams, Gabriel Herrero‐Beaumont, Raquel Largo, Aránzazu Mediero   +13 more
wiley   +1 more source

Purinergic signalling in osteoblasts

Frontiers in Bioscience, 2012
The skeleton is maintained throughout life via the finely tuned actions of osteoblasts and osteoclasts, with disruption in this balance eventually leading to bone disease. The exact mechanisms balancing these actions are not fully known, although several regulatory systems are known to be involved.
Gartland, Alison, Orriss, Isabel R., Rumney, Robin M.H., Bond, Alistair P., Arnett, Timothy, Gallagher, James A.   +5 more
openaire   +3 more sources

Myocardial metabolism in heart failure: Purinergic signalling and other metabolic concepts

Pharmacology and Therapeutics, 2019
Despite significant therapeutic advances in heart failure (HF) therapy, the morbidity and mortality associated with this disease remains unacceptably high.
A. Birkenfeld, J. Jordan, M. Dworak, T. Merkel, G. Burnstock   +4 more
semanticscholar   +1 more source

Connexin communication compartments and wound repair in epithelial tissue [PDF]

, 2018
Epithelial tissues line the lumen of tracts and ducts connecting to the external environment. They are critical in forming an interface between the internal and external environment and, following assault from environmental factors and pathogens, they ...
Chanson, Marc, Martin, Patricia E., O'Shaughnessy, Erin M., Watanabe, Masakatsu, Zoso, Alice   +4 more
core   +4 more sources

Clock genes regulate Ca2+ signaling and mitochondrial bioenergetics to inhibit Sjogren's disease

Arthritis &Rheumatology, Accepted Article.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjogren's disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA seq, and mitochondrial activity were used to investigate the effects of ...
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento Da Conceicao, Neelanjan Vishnu, Shankara N Varadarajan, Venugopal R. Bovilla, Rajender K Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

Purinergic Signaling in Liver Disease [PDF]

Digestive Diseases, 2014
Adenosine triphosphate (ATP) is essential for the myriad of metabolic processes upon which life is based and is known widely as the universal energy currency unit of intracellular biologic reactions. ATP, adenosine diphosphate, adenosine, as well as other purines and pyrimidines also serve as ubiquitous extracellular mediators which function through ...
Byron P, Vaughn, Simon C, Robson, Maria Serena, Longhi   +2 more
openaire   +2 more sources