Results 1 to 10 of about 53,976 (309)

E. coli genetically modified for purine nucleobase release promotes butyrate generation and colonic wound healing during DSS insult [PDF]

Gut Microbes
The gut microbiota transforms energy stored as undigestible carbohydrates into a remarkable number of metabolites that fuel intestinal bacterial communities and the host tissue.
J. Scott Lee, Daniel J. Kao, Corey S. Worledge, Zachary F. Villamaria, Ruth X. Wang, Nichole M. Welch, Rachael E. Kostelecky, Sean P. Colgan   +7 more
doaj   +2 more sources

Infrared Spectral Signatures of Nucleobases in Interstellar Ices I: Purines

Life, 2023
The purine nucleobases adenine and guanine are complex organic molecules that are essential for life. Despite their ubiquitous presence on Earth, purines have yet to be detected in observations of astronomical environments.
Caroline Antunes Rosa, Alexandre Bergantini, Péter Herczku, Duncan V. Mifsud, Gergő Lakatos, Sándor T. S. Kovács, Béla Sulik, Zoltán Juhász, Sergio Ioppolo, Heidy M. Quitián-Lara, Nigel J. Mason, Claudia Lage   +11 more
doaj   +1 more source

Protonated pyrimidine-purine-purine triplex [PDF]

Nucleic Acids Research, 1993
We have studied a protonated pyrimidine-purine-purine (Py-Pu-Pu) triplex, which is formed between the d(C)nd(G)n duplex and the d(AG)m oligonucleotide as the third strand and carries the CG*A+ protonated base-triads. We have observed such an intermolecular complex between a plasmid carrying the d(C)18 d(G)18 insert and the d(AG)5 oligonucleotide ...
Ingeborg Jansen, Vladislav A. Malkov, Alexei G. Veselkov, Oleg N. Voloshin, Oleg N. Voloshin, Victor M. Rostapshov, Valery N. Soyfer, Maxim D. Frank-Kamenetskii   +7 more
openaire   +3 more sources

The interaction of aflatoxins with purines and purine nucleosides [PDF]

Biochemical Journal, 1967
From measurements of thermal hyperchromicity and the behaviour of an aflatoxin-DNA mixture on a Sephadex column it was concluded that aflatoxin B(1) is capable of weak binding to single-stranded DNA. The interactions of the aflatoxins (B(1), G(1) and G(2)) with nucleosides result in difference spectra and suggest that the purine bases and the amino ...
K. R. Rees, Janet I. Clifford
openaire   +3 more sources

Structure–activity features of purines and their receptors: implications in cell physiopathology

Molecular Biomedicine, 2022
The purine molecular structure consists of fused pyrimidine and imidazole rings. Purines are main pieces that conform the structure of nucleic acids which rule the inheritance processes.
Mauricio Díaz-Muñoz, Rolando Hernández-Muñoz, Armando Butanda-Ochoa   +2 more
doaj   +1 more source

Novel Point-of-Care Diagnostic Method for Neonatal Encephalopathy Using Purine Nucleosides

Frontiers in Molecular Neuroscience, 2021
Background: Evidence suggests that earlier diagnosis and initiation of treatment immediately after birth is critical for improved neurodevelopmental outcomes following neonatal encephalopathy (NE). Current diagnostic tests are, however, mainly restricted
Edward Beamer, Edward Beamer, Mary Isabel O’Dea, Mary Isabel O’Dea, Mary Isabel O’Dea, Mary Isabel O’Dea, Aisling A. Garvey, Aisling A. Garvey, Jonathon Smith, Jonathon Smith, Aida Menéndez-Méndez, Lynne Kelly, Lynne Kelly, Andreea Pavel, Andreea Pavel, Sean Quinlan, Mariana Alves, Eva M. Jimenez-Mateos, Faming Tian, Eugene Dempsey, Eugene Dempsey, Nicholas Dale, Deirdre M. Murray, Deirdre M. Murray, Geraldine B. Boylan, Geraldine B. Boylan, Eleanor J. Molloy, Eleanor J. Molloy, Eleanor J. Molloy, Eleanor J. Molloy, Tobias Engel, Tobias Engel   +31 more
doaj   +1 more source

Regioselective synthesis of triazolo[3,4-e]purine derivatives and their anti-cancer activity against NCI-60 cell-lines [PDF]

Folia Medica, 2021
Introduction: Due to the vast medicinal importance of purine nucleoside, a hybrid molecule of triazole with purine ring might explode a lead molecule in the pharma sector and based on the last decade’s studies suggested that the ...
Khushal Kapadiya, Kishor Kavadia, Jyoti Gohel, Ranjan Khunt   +3 more
doaj   +3 more sources

Purine-Furan and Purine-Thiophene Conjugates [PDF]

Molbank, 2018
Furyl and thienyl moieties were introduced into a purine structure to elevate its fluorescence properties, while a trityl group was used to increase the amorphous properties of the purine compounds. The title compounds were prepared by a sequence involving a Mitsunobu, a SNAr and a Suzuki–Miyaura reaction and their photophysical properties were studied.
Zigfrīds Kapilinskis, Irina Novosjolova, Māris Turks   +2 more
openaire   +2 more sources

A New Class of Nucleosides. Synthesis, Reactivity and Biological Activity of Keto-Hexose Nucleosides

CHIMIA, 1975
Direct oxydation of sterically hindered hexosyl purines led to keto-hexosylpurines, important synthetic intermediates. The first unsaturated keto-nucleosides have also been obtained by acetylation of the corresponding keto-hexosyl purines.
K. Antonakis
doaj   +1 more source

Purinergic Signalling in Inflammatory Renal Disease

Frontiers in Physiology, 2013
Extracellular purines have a role in renal physiology and adaption to inflammation. However, inflammatory renal disease may be mediated by extracellular purines, resulting in renal injury.
Nishkantha eArulkumaran, Nishkantha eArulkumaran, Clare eTurner, Marije eSixma, Mervyn eSinger, Robert John Unwin, Frederick WK Tam   +6 more
doaj   +1 more source