E. coli genetically modified for purine nucleobase release promotes butyrate generation and colonic wound healing during DSS insult [PDF]
Gut MicrobesThe gut microbiota transforms energy stored as undigestible carbohydrates into a remarkable number of metabolites that fuel intestinal bacterial communities and the host tissue.
J. Scott Lee +7 more
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Infrared Spectral Signatures of Nucleobases in Interstellar Ices I: Purines
Life, 2023 The purine nucleobases adenine and guanine are complex organic molecules that are essential for life. Despite their ubiquitous presence on Earth, purines have yet to be detected in observations of astronomical environments.
Caroline Antunes Rosa +11 more
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Structure–activity features of purines and their receptors: implications in cell physiopathology
Molecular Biomedicine, 2022 The purine molecular structure consists of fused pyrimidine and imidazole rings. Purines are main pieces that conform the structure of nucleic acids which rule the inheritance processes.
Mauricio Díaz-Muñoz +2 more
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Regioselective synthesis of triazolo[3,4-e]purine derivatives and their anti-cancer activity against NCI-60 cell-lines [PDF]
Folia Medica, 2021 Introduction: Due to the vast medicinal importance of purine nucleoside, a hybrid molecule of triazole with purine ring might explode a lead molecule in the pharma sector and based on the last decade’s studies suggested that the ...
Khushal Kapadiya +3 more
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Translational Oncology, 2023 Background: Although imatinib is a well-established first-line drug for treating a vast majority of gastrointestinal stromal tumours (GIST), GISTs acquire secondary resistance during therapy.
Szymon Macioszek +8 more
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Novel Point-of-Care Diagnostic Method for Neonatal Encephalopathy Using Purine Nucleosides
Frontiers in Molecular Neuroscience, 2021 Background: Evidence suggests that earlier diagnosis and initiation of treatment immediately after birth is critical for improved neurodevelopmental outcomes following neonatal encephalopathy (NE). Current diagnostic tests are, however, mainly restricted
Edward Beamer +31 more
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A New Class of Nucleosides. Synthesis, Reactivity and Biological Activity of Keto-Hexose Nucleosides
CHIMIA, 1975 Direct oxydation of sterically hindered hexosyl purines led to keto-hexosylpurines, important synthetic intermediates. The first unsaturated keto-nucleosides have also been obtained by acetylation of the corresponding keto-hexosyl purines.
K. Antonakis
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Purinergic Signalling in Inflammatory Renal Disease
Frontiers in Physiology, 2013 Extracellular purines have a role in renal physiology and adaption to inflammation. However, inflammatory renal disease may be mediated by extracellular purines, resulting in renal injury.
Nishkantha eArulkumaran +6 more
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The exercise sex gap and the impact of the estrous cycle on exercise performance in mice
Scientific Reports, 2018 Exercise physiology is different in males and females. Females are poorly studied due to the complexity of the estrous cycle and this bias has created an exercise sex gap.
Aderbal S. Aguiar +4 more
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Revista Brasileira de Zootecnia, 2010 Objetivou-se analisar a variação do pH, da amônia ruminal e do balanço de compostos nitrogenados e a síntese de proteína microbiana de 12 vacas da raça Holandesa distribuídas em três quadrados latinos 4 × 4, alimentadas com dietas contendo soja em ...
Angela Maria de Vasconcelos +5 more
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