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Infrared Spectral Signatures of Nucleobases in Interstellar Ices I: Purines

open access: yesLife, 2023
The purine nucleobases adenine and guanine are complex organic molecules that are essential for life. Despite their ubiquitous presence on Earth, purines have yet to be detected in observations of astronomical environments.
Caroline Antunes Rosa   +11 more
doaj   +1 more source

Regioselective synthesis of triazolo[3,4-e]purine derivatives and their anti-cancer activity against NCI-60 cell-lines [PDF]

open access: yesFolia Medica, 2021
Introduction: Due to the vast medicinal importance of purine nucleoside, a hybrid molecule of triazole with purine ring might explode a lead molecule in the pharma sector and based on the last decade’s studies suggested that the ...
Khushal Kapadiya   +3 more
doaj   +3 more sources

Synthesis and Biological Activity of 3-(Heteroaryl)quinolin-2(1H)-ones Bis-Heterocycles as Potential Inhibitors of the Protein Folding Machinery Hsp90

open access: yesMolecules, 2022
In the context of our SAR study concerning 6BrCaQ analogues as C-terminal Hsp90 inhibitors, we designed and synthesized a novel series of 3-(heteroaryl)quinolin-2(1H), of types 3, 4, and 5, as a novel class of analogues.
Enrique L. Larghi   +5 more
doaj   +1 more source

Purine Auxotrophic Starvation Evokes Phenotype Similar to Stationary Phase Cells in Budding Yeast

open access: yesJournal of Fungi, 2021
Purine auxotrophy is an abundant trait among eukaryotic parasites and a typical marker for many budding yeast strains. Supplementation with an additional purine source (such as adenine) is necessary to cultivate these strains. If not supplied in adequate
Agnese Kokina   +6 more
doaj   +1 more source

Structure–activity features of purines and their receptors: implications in cell physiopathology

open access: yesMolecular Biomedicine, 2022
The purine molecular structure consists of fused pyrimidine and imidazole rings. Purines are main pieces that conform the structure of nucleic acids which rule the inheritance processes.
Mauricio Díaz-Muñoz   +2 more
doaj   +1 more source

Scientific investigations of the Nobel prize winner Emil Fischer as a launching pad for the development of biochemistry: a brief overview [PDF]

open access: yesThe Ukrainian Biochemical Journal, 2018
Modern biochemistry and molecular biology would be impossible without discoveries in related fields of science. This paper aims to outline briefly the main stages of scientific activity of a Nobel Prize winner 1902 – German chemist Hermann Emil Fischer ...
T. V. Danylova, S. V. Komisarenko
doaj   +1 more source

Changes in the Concentration of Purine and Pyridine as a Response to Single Whole-Body Cryostimulation

open access: yesFrontiers in Physiology, 2021
To our knowledge, this is the first study in which we provide evidence that a single whole-body cryostimulation treatment leads to changes associated with erythrocyte energy metabolism.
Wioleta Dudzinska   +2 more
doaj   +1 more source

Último recuento: una estrategia efectiva para la evaluación de indicadores de germinación en especies forrajeras en situaciones de estrés

open access: yesCiencia y Tecnología Agropecuaria, 2023
Existen pruebas estandarizadas para evaluar la calidad de las semillas y para ensayos de biomonitoreo ambiental, las cuales utilizan indicadores que permiten establecer la sensibilidad de diversas especies a condiciones ambientales, aunque los momentos ...
Lorna Ileana Carbó   +4 more
doaj   +1 more source

The exercise sex gap and the impact of the estrous cycle on exercise performance in mice

open access: yesScientific Reports, 2018
Exercise physiology is different in males and females. Females are poorly studied due to the complexity of the estrous cycle and this bias has created an exercise sex gap.
Aderbal S. Aguiar   +4 more
doaj   +1 more source

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