Protonated pyrimidine-purine-purine triplex [PDF]
Nucleic Acids Research, 1993 We have studied a protonated pyrimidine-purine-purine (Py-Pu-Pu) triplex, which is formed between the d(C)nd(G)n duplex and the d(AG)m oligonucleotide as the third strand and carries the CG*A+ protonated base-triads. We have observed such an intermolecular complex between a plasmid carrying the d(C)18 d(G)18 insert and the d(AG)5 oligonucleotide ...
Ingeborg Jansen +7 more
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The interaction of aflatoxins with purines and purine nucleosides [PDF]
Biochemical Journal, 1967 From measurements of thermal hyperchromicity and the behaviour of an aflatoxin-DNA mixture on a Sephadex column it was concluded that aflatoxin B(1) is capable of weak binding to single-stranded DNA. The interactions of the aflatoxins (B(1), G(1) and G(2)) with nucleosides result in difference spectra and suggest that the purine bases and the amino ...
K. R. Rees, Janet I. Clifford
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Ischemic preconditioning attenuates portal venous plasma concentrations of purines following warm liver ischemia in man [PDF]
, 2005 Background/Aims: Degradation of adenine nucleotides to adenosine has been suggested to play a critical role in ischemic preconditioning (IPC). Thus, we questioned in patients undergoing partial hepatectomy whether (i) IPC will increase plasma purine ...
Chouker, A. +9 more
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Purine-Furan and Purine-Thiophene Conjugates [PDF]
Molbank, 2018 Furyl and thienyl moieties were introduced into a purine structure to elevate its fluorescence properties, while a trityl group was used to increase the amorphous properties of the purine compounds. The title compounds were prepared by a sequence involving a Mitsunobu, a SNAr and a Suzuki–Miyaura reaction and their photophysical properties were studied.
Zigfrīds Kapilinskis +2 more
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Biosensor measurement of purine release from cerebellar cultures and slices [PDF]
, 2010 We have previously described an action-potential and Ca2+-dependent form of adenosine release in the molecular layer of cerebellar slices. The most likely source of the adenosine is the parallel fibres, the axons of granule cells. Using microelectrode
Dale, Nicholas +2 more
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Hoogsteen base pairs proximal and distal to echinomycin binding sites on DNA [PDF]
, 1987 Forms of the DNA double helix containing non-Watson-Crick base-pairing have been discovered recently based on x-ray diffraction analysis of quinoxaline antibiotic-oligonucleotide complexes.
Dervan, Peter B., Mendel, David
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The dynamics of single spike-evoked adenosine release in the cerebellum [PDF]
, 2010 The purine adenosine is a potent neuromodulator in the brain, with roles in a number of diverse physiological and pathological processes. Modulators such as adenosine are difficult to study as once released they have a diffuse action (which can affect ...
Beierlein +41 more
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Cardiovascular Pharmacology of Purines [PDF]
Clinical Science, 1997 1. This review focuses on the extracellular actions of ATP and adenosine, and in particular their role in cardiovascular regulation. 2. ATP serves as a co-transmitter within the sympathetic nervous system, and is also released from endothelium and aggregating thrombocytes.
Rongen, G.A.P.J.M. +4 more
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Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mostly mediated by the human Equilibrative Nucleoside Transporter and the human Facilitative Nucleobase Transporter [PDF]
, 2010 <b>Background</b>: Plasmodium parasites are unable to synthesize purines de novo and have to salvage them from the host. Due to this limitation in the parasite, purine transporters have been an area of focus in the search for anti-malarial ...
De Koning, H.P. +2 more
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Resetting intrinsic purinergic modulation of neural activity: an associative mechanism? [PDF]
, 2002 The purines, ATP and adenosine, control the rundown and termination of swimming in the Xenopus embryo. This intrinsic purinergic modulation, unavoidably present during every swimming episode, could lead to stereotyped inflexible behavior and consequently
Dale, Nicholas
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