Results 1 to 10 of about 52,952 (237)
Synthesis of Indole Derivatives via Aryl Triazole Ring-Opening and Subsequent Cyclization. [PDF]
MoleculesA metal-free two-step synthetic approach for obtaining indole derivatives from aryl triazole fragment-containing compounds has been developed. In the first step, the Dimroth equilibrium, followed by nitrogen extrusion, Wolff rearrangement, and amine ...
Burcevs A +4 more
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Infrared Spectral Signatures of Nucleobases in Interstellar Ices I: Purines
Life, 2023 The purine nucleobases adenine and guanine are complex organic molecules that are essential for life. Despite their ubiquitous presence on Earth, purines have yet to be detected in observations of astronomical environments.
Caroline Antunes Rosa +11 more
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Protonated pyrimidine-purine-purine triplex [PDF]
Nucleic Acids Research, 1993 We have studied a protonated pyrimidine-purine-purine (Py-Pu-Pu) triplex, which is formed between the d(C)nd(G)n duplex and the d(AG)m oligonucleotide as the third strand and carries the CG*A+ protonated base-triads. We have observed such an intermolecular complex between a plasmid carrying the d(C)18 d(G)18 insert and the d(AG)5 oligonucleotide ...
Ingeborg Jansen +7 more
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Novel Point-of-Care Diagnostic Method for Neonatal Encephalopathy Using Purine Nucleosides
Frontiers in Molecular Neuroscience, 2021 Background: Evidence suggests that earlier diagnosis and initiation of treatment immediately after birth is critical for improved neurodevelopmental outcomes following neonatal encephalopathy (NE). Current diagnostic tests are, however, mainly restricted
Edward Beamer +31 more
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Regioselective synthesis of triazolo[3,4-e]purine derivatives and their anti-cancer activity against NCI-60 cell-lines [PDF]
Folia Medica, 2021 Introduction: Due to the vast medicinal importance of purine nucleoside, a hybrid molecule of triazole with purine ring might explode a lead molecule in the pharma sector and based on the last decade’s studies suggested that the ...
Khushal Kapadiya +3 more
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Structure–activity features of purines and their receptors: implications in cell physiopathology
Molecular Biomedicine, 2022 The purine molecular structure consists of fused pyrimidine and imidazole rings. Purines are main pieces that conform the structure of nucleic acids which rule the inheritance processes.
Mauricio Díaz-Muñoz +2 more
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The interaction of aflatoxins with purines and purine nucleosides [PDF]
Biochemical Journal, 1967 From measurements of thermal hyperchromicity and the behaviour of an aflatoxin-DNA mixture on a Sephadex column it was concluded that aflatoxin B(1) is capable of weak binding to single-stranded DNA. The interactions of the aflatoxins (B(1), G(1) and G(2)) with nucleosides result in difference spectra and suggest that the purine bases and the amino ...
K. R. Rees, Janet I. Clifford
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Purine-Furan and Purine-Thiophene Conjugates [PDF]
Molbank, 2018 Furyl and thienyl moieties were introduced into a purine structure to elevate its fluorescence properties, while a trityl group was used to increase the amorphous properties of the purine compounds. The title compounds were prepared by a sequence involving a Mitsunobu, a SNAr and a Suzuki–Miyaura reaction and their photophysical properties were studied.
Zigfrīds Kapilinskis +2 more
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Frontiers in Physiology, 2021 To our knowledge, this is the first study in which we provide evidence that a single whole-body cryostimulation treatment leads to changes associated with erythrocyte energy metabolism.
Wioleta Dudzinska +2 more
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