Results 71 to 80 of about 53,210 (333)

A DNP‐Supported Solid‐State NMR Approach to Study Nucleic Acids In Situ Reveals Berberine‐Stabilized Hoogsteen Structures in Mitochondria

Angewandte Chemie, EarlyView.
Mitochondria are vital for energy production and rely on intricate nucleic acid structures to regulate gene expression. Using DNP‐ssNMR (dynamic nuclear polarization solid‐state NMR), we observed G‐quadruplex formation in intact mitochondria treated with berberine.
Michaela Dzurov Krafčíková, David Beriashvili, Salima Bahri, Menno Bergmeijer, Stuart C. Howes, Andrei Gurinov, Friedrich G. Förster, Gert E. Folkers, Marc Baldus   +8 more
wiley   +2 more sources

Purine and carbohydrate availability drive Enterococcus faecalis fitness during wound and urinary tract infections

mBio
Enterococcus faecalis is commonly isolated from a variety of wound types. Despite its prevalence, the pathogenic mechanisms of E. faecalis during wound infection are poorly understood. Using a mouse wound infection model, we performed in vivo E. faecalis
Casandra Ai Zhu Tan, Kelvin Kian Long Chong, Daryl Yu Xuan Yeong, Celine Hui Min Ng, Muhammad Hafiz Ismail, Zhei Hwee Yap, Varnica Khetrapal, Vanessa Shi Yun Tay, Daniela I. Drautz-Moses, Yusuf Ali, Swaine L. Chen, Kimberly A. Kline   +11 more
doaj   +1 more source

Solution of the Crow-Kimura and Eigen models for alphabets of arbitrary size by Schwinger spin coherent states [PDF]

, 2009
To represent the evolution of nucleic acid and protein sequence, we express the parallel and Eigen models for molecular evolution in terms of a functional integral representation with an $h$-letter alphabet, lifting the two-state, purine/pyrimidine assumption often made in quasi-species theory. For arbitrary $h$ and a general mutation scheme, we obtain
arxiv   +1 more source

Hierarchical Regulatory Networks Reveal Conserved Drivers of Plant Drought Response at the Cell‐Type Level

Advanced Science, EarlyView.
This study presents a comprehensive multi‐omics framework to uncover cell‐type‐specific regulatory networks in plant drought responses. By integrating transcriptomic, proteomic, and epigenetic data from nearly 30 000 samples, key regulators such as CIPK23 and NLP7 are identified, revealing insights into conserved drought tolerance mechanisms and ...
Moyang Liu, Yuanyuan Xu, Yue Song, Dongying Fan, Junpeng Li, Zhen Zhang, Lujia Wang, Juan He, Cheng Chen, Chao Ma   +9 more
wiley   +1 more source

Harnessing Molecular Recognition for Small‐Molecule‐Mediated Reversible Photochemical Control Over mRNA Translation

Angewandte Chemie, EarlyView.
A small molecule ligand undergoes traceless, reversible photocrosslinking to PreQ1 RNA aptamer in a selective manner, dependent on both the RNA sequence/structure and ligand chemical structure. A caged mRNA construct incorporating the PreQ1 aptamer and an eGFP or p53 coding sequence remained translationally repressed until exposure to 302 nm light ...
Shaifaly Parmar, Logan Tenney, Xiao Liang, John T. Routzahn IV, Christopher D. Sibley, John S. Schneekloth Jr.   +5 more
wiley   +2 more sources

P2X4 signalling contributes to hyperactivity but not pain sensitization comorbidity in a mouse model of attention deficit/hyperactivity disorder

Frontiers in Pharmacology
Introduction: Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by hyperactivity, inattention, and impulsivity that often persist until adulthood.
Sarah Bou Sader Nehme, Sarah Bou Sader Nehme, Sandra Sanchez-Sarasua, Sandra Sanchez-Sarasua, Ramy Adel, Marie Tuifua, Awatef Ali, Amina E. Essawy, Sherine Abdel Salam, Walid Hleihel, Eric Boué-Grabot, Marc Landry   +11 more
doaj   +1 more source

Lie Markov models with purine/pyrimidine symmetry [PDF]

arXiv, 2012
Continuous-time Markov chains are a standard tool in phylogenetic inference. If homogeneity is assumed, the chain is formulated by specifying time-independent rates of substitutions between states in the chain. In applications, there are usually extra constraints on the rates, depending on the situation.
arxiv  

DISORDERS OF PURIN METABOLISM [PDF]

Journal of the American Medical Association, 1912
The old time term "uric acid diathesis" was an elastic expression, embracing such different conditions as gout, chronic rheumatism, uratic calculus, obesity and certain nephritides. In the light of more recent knowledge, the meaning of the term has been gradually narrowed until at the present time it includes only those diseases or clinical syndromes ...
Alfred C. Reed, George B. Wallace
openaire   +3 more sources

Single Test‐Based Diagnosis and Subtyping of Pulmonary Hypertension Caused by Fibrosing Mediastinitis Using Plasma Metabolic Analysis

Advanced Science, EarlyView.
Pulmonary hypertension caused by fibrosing mediastinitis has a five‐year survival rate of just 56%. Current diagnostic approaches are complex for patients with mobility limitations and can lead to misdiagnoses due to their nonspecific clinical features.
Yating Zhao, Chunmeng Ding, Hongling Su, Aqian Wang, Aiping Tang, Hongfan Zhao, Ya Ma, Min Zhang, Wanshan Liu, Ruimin Wang, Ziyue Zhang, Shouzhi Yang, Dingyitai Liang, Yida Huang, Kun Qian, Lin Huang, Qihua Fu, Yunshan Cao   +17 more
wiley   +1 more source

Efficient Synthesis of Novel Triazolo[5,1-b]purines by Diacetoxyiodobenzene-Mediated Oxidative Cyclization of Schiff Bases

Reactions
In this work, we have developed a method for synthesizing new 8-substituted triazolo[5,1-b]purines using diacetoxyiodobenzene as an oxidizing agent with good yields (59–67%).
Artyom O. Neymash, Victor V. Fedotov, Evgeny N. Ulomsky, Daniil N. Lyapustin, Semen V. Aminov, Vladimir L. Rusinov   +5 more
doaj   +1 more source