Results 61 to 70 of about 50,189 (192)

2,6-Disubstituted and 2,6,8-Trisubstituted Purines as Adenosine Receptor Antagonists

, 2016
Purines have long been exploited as adenosine receptor antagonists. The substitution pattern about the purine ring has been well investigated, and certain criteria have become almost a prerequisite for good affinity at the adenosine A1 receptor.
Thea Mulder-Krieger (2051212), Ronald F. Spanjersberg (2639986), Jacobien K. von Frijtag Drabbe Künzel (2503726), Lisa C. W. Chang (2503723), Adriaan P. IJzerman (195167), Johannes Brussee (1816744)   +5 more
core   +1 more source

Efficient Synthesis of Novel Triazolo[5,1-b]purines by Diacetoxyiodobenzene-Mediated Oxidative Cyclization of Schiff Bases

Reactions
In this work, we have developed a method for synthesizing new 8-substituted triazolo[5,1-b]purines using diacetoxyiodobenzene as an oxidizing agent with good yields (59–67%).
Artyom O. Neymash, Victor V. Fedotov, Evgeny N. Ulomsky, Daniil N. Lyapustin, Semen V. Aminov, Vladimir L. Rusinov   +5 more
doaj   +1 more source

Synthesis of Adenine Nucleosides with a Reactive (β-Iodovinyl)sulfone or (β-Keto)sulfone Group at the C2 Position and Their Polymerase-Catalyzed Incorporation into DNA

Molecules
Iodosulfonylation of an ethynyl group at the C2 position of 2′-deoxyadenosine or adenosine with TsI provides (E)-2-(β-iodovinyl)sulfones. The latter undergo nucleophilic substitution with amines via an addition–elimination to give β-sulfonylvinylamines ...
A. Hasan Howlader, Richard Fernandez, Pawlos S. Tsegay, Yuan Liu, Stanislaw F. Wnuk   +4 more
doaj   +1 more source

Polyoxotungstates in Molecular Boxes of Purine Bases

Crystals, 2014
Three new compounds, (GuaH)4[W10O32](H2O)4 (1), (ThbH)3(H3O)[(W10O32](H2O)7.5 (2) and (ThbH)2[W6O19](H2O)2 (3) (GuaH = guaninium, thbH = theobrominium) were synthesized in acidified acetonitrile solutions.
Vladislav Kulikov, Gerd Meyer
doaj   +1 more source

Lactobacillus gasseri PA-3 Uses the Purines IMP, Inosine and Hypoxanthine and Reduces their Absorption in Rats

, 2017
Excessive intake of purine-rich foods elevates serum levels of uric acid. Animal and fish meats contain high amounts of inosine and its related purines, and the reduction of taking those purines is crucial for the improvement of serum uric acid levels ...
Yukio Asami, Chizuru Saito-Iwamoto, Marie Nakamura, Naruomi Yamada, Hiroshi Kano, Yoshika Chiba, Misato Soeda   +6 more
core   +1 more source

P2X4 signalling contributes to hyperactivity but not pain sensitization comorbidity in a mouse model of attention deficit/hyperactivity disorder

Frontiers in Pharmacology
Introduction: Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by hyperactivity, inattention, and impulsivity that often persist until adulthood.
Sarah Bou Sader Nehme, Sarah Bou Sader Nehme, Sandra Sanchez-Sarasua, Sandra Sanchez-Sarasua, Ramy Adel, Marie Tuifua, Awatef Ali, Amina E. Essawy, Sherine Abdel Salam, Walid Hleihel, Eric Boué-Grabot, Marc Landry   +11 more
doaj   +1 more source

Purine Phosphoribosyltransferases [PDF]

Journal of Biological Chemistry, 2000
S P, Craig, A E, Eakin
openaire   +2 more sources

Synthesis and Fluorescent Properties of New N(9)-Substituted Push-pull purines

Push-pull purine derivatives are attractive as sensors and reporters for biological applications. Recently the fluorescent purines as materials for electronic devices have also been developed.
Šišuļins, Andrejs, Māliņa, Ilze, Bizdēna, Ērika, Turks, Māris   +3 more
core  

Release of endogenous and radioactive purines from the rabbit retina

, 1986
The adenine nucleotide pool of rabbit retina was labeled by an intravitreal injection in vivo of [3H]adenosine. Practically all the radioactivity was retained in the form of adenine nucleotides.
Lindström, K, Ehinger, B E,, Perez, M T, Ehinger, B E, Perez, M T,, Fredholm, B B, Lund University.   +6 more
core   +1 more source

Purine and carbohydrate availability drive Enterococcus faecalis fitness during wound and urinary tract infections

mBio
Enterococcus faecalis is commonly isolated from a variety of wound types. Despite its prevalence, the pathogenic mechanisms of E. faecalis during wound infection are poorly understood. Using a mouse wound infection model, we performed in vivo E. faecalis
Casandra Ai Zhu Tan, Kelvin Kian Long Chong, Daryl Yu Xuan Yeong, Celine Hui Min Ng, Muhammad Hafiz Ismail, Zhei Hwee Yap, Varnica Khetrapal, Vanessa Shi Yun Tay, Daniela I. Drautz-Moses, Yusuf Ali, Swaine L. Chen, Kimberly A. Kline   +11 more
doaj   +1 more source