Results 51 to 60 of about 49,628 (295)

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Meat quality of rabbits reared with two different feeding strategies: with or without fresh alfalfa ad libitum

World Rabbit Science, 2013
The aim of this study was to evaluate production performance, carcass characteristics and nutritive value of meat of rabbits reared under the 2 prevailing feeding strategies in Uruguay.
Gustavo Capra, Rosana Martínez, Florenca Fradiletti, Sonia Cozzano, Luis Repiso, Rosa Márquez, Facundo Ibáñez   +6 more
doaj   +1 more source

Functionalities of Purines in Health and Disease

, 2019
Purines conduct several vital cellular functions as in the production of the numeric-precursors of nucleic acids, whereas excess formation of uric acid generated from purines metabolism has been expansively implicated in human disease.
Dr Chrysanthus Chukwuma Sr, Sr, Chrysanthus Chukwuma   +1 more
core   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

RNA Catabolites Contribute to the Nitrogen Pool and Support Growth Recovery of Wheat

Frontiers in Plant Science, 2018
Turn-over of RNA and catabolism of nucleotides releases one to four ammonia molecules; the released nutrients being reassimilated into primary metabolism.
Vanessa Jane Melino, Vanessa Jane Melino, Alberto Casartelli, Jessey George, Thusitha Rupasinghe, Ute Roessner, Mamoru Okamoto, Sigrid Heuer, Sigrid Heuer   +8 more
doaj   +1 more source

Selective Synthesis of 7-Substituted Purines via 7,8-Dihydropurines

, 2016
A simple and efficient protocol for the preparation of 7-substituted purines is described. 6- and 2,6-Dihalopurines were N9-tritylated and then transformed to 7,8-dihydropurines by DIBAL-H. Subsequent N7-alkylation followed by N9-trityl deprotection with
Tomáš Tobrman (1677046), Dalimil Dvořák (1716517), Naděžda Chudíková (2243374), Vladislav Kotek (1677049)   +3 more
core   +1 more source

SERS analysis of cancer cell-secreted purines reveals a unique paracrine crosstalk in MTAP-deficient tumors

, 2023
<p>Dataset of the paper: Valera, PS; Plou, J; García, I; Astobiza, I; Viera, C; M. Aransay, A; Martin, JE; Sasselli, IR; Carracedo, A; Liz-Marzán, LM.
Plou, Javier, R. Sasselli, Ivan, Sasselli, Ivan R., Carracedo, Arkaitz, Aransay, Ana M., Liz-Marzán, Luis M., Martín, José E., Astobiza, Ianire, García, Isabel, Viera, Cristina, Valera, Pablo S., Liz-Marzán, Luis Manuel   +11 more
core   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Synthesis of Indole Derivatives via Aryl Triazole Ring-Opening and Subsequent Cyclization

Molecules
A metal-free two-step synthetic approach for obtaining indole derivatives from aryl triazole fragment-containing compounds has been developed. In the first step, the Dimroth equilibrium, followed by nitrogen extrusion, Wolff rearrangement, and amine ...
Aleksejs Burcevs, Armands Sebris, Irina Novosjolova, Anatoly Mishnev, Māris Turks   +4 more
doaj   +1 more source

Making Sweat Measurable: Induction, Sampling, and Refreshment in Wearable Biofluid Sensing

Advanced Science, EarlyView.
Wearable sweat sensing relies not only on chemical detection but also on controlled biofluid management. This Review integrates sweat physiology, induction strategies, and microfluidic sampling architectures, demonstrating how flux, transport, and refreshment shape measurement reliability.
Soyoung Shin, Wei Gao
wiley   +1 more source