Results 51 to 60 of about 77,275 (204)
The Intersection of Purine and Mitochondrial Metabolism in Cancer
Cells, 2021 Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of ...
Humberto De Vitto +3 more
doaj +1 more source
An organometallic compound which exhibits a DNA topology-dependent one-stranded intercalation mode [PDF]
, 2016 Understanding how small molecules interact with DNA is essential since it underlies a multitude of pathological conditions and therapeutic interventions.
Adhireksan +16 more
core +3 more sources
Antibiotics, 2015 Chronic infections with Staphylococcus aureus such as septicemia, osteomyelitis, endocarditis, and biofilm infections are difficult to treat because of persisters.
Rebecca Yee +4 more
doaj +1 more source
Dual control of vascular tone and remodelling by ATP released from nerves and endothelial cells [PDF]
, 2008 Purinergic signalling is important both in short-term control of vascular tone and in longer-term control of cell proliferation, migration and death involved in vascular remodelling.
Burnstock, G
core
2,6-Bis[4-(4-butylphenyl)-1H-1,2,3-triazol-1-yl]-9-dodecyl-9H-purine
Molbank, 2019 Target 2,6-bis[4-(4-butylphenyl)-1H-1,2,3-triazol-1-yl]-9-dodecyl-9H-purine has been prepared via a Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition reaction between 2,6-diazido-9-dodecyl-9H-purine and 4-n-butyl(phenylacetylene) in a 29% yield. The
Andrejs Šišuļins +3 more
doaj +1 more source
Recognition of abasic sites and single base bulges in DNA by a metalloinsertor [PDF]
, 2009 Abasic sites and single base bulges are thermodynamically destabilizing DNA defects that can lead to cancerous transformations if left unrepaired by the cell.
Barton, Jacqueline K. +2 more
core +1 more source
Purine nucleoside phosphorylase [PDF]
Biomeditsinskaya Khimiya, 2013 Purine nucleoside phosphorylase (PNP) is one of the most important enzymes of the purine metabolism, wich promotes the recycling of purine bases. Nowadays is the actual to search for effective inhibitors of this enzyme which is necessary for creation T-cell immunodeficient status of the organism in the organs and tissues transplantation, and ...
L G, Pogosian, Zh I, Akopian
openaire +2 more sources
Substituted Purines as High-Affinity Histamine H3 Receptor Ligands
Pharmaceuticals, 2022 Continuing with our program to obtain new histamine H3 receptor (H3R) ligands, in this work we present the synthesis, H3R affinity and in silico studies of a series of eight new synthetically accessible purine derivatives.
Christian Espinosa-Bustos +7 more
doaj +1 more source
World Rabbit Science, 2013 The aim of this study was to evaluate production performance, carcass characteristics and nutritive value of meat of rabbits reared under the 2 prevailing feeding strategies in Uruguay.
Gustavo Capra +6 more
doaj +1 more source
RNA Catabolites Contribute to the Nitrogen Pool and Support Growth Recovery of Wheat
Frontiers in Plant Science, 2018 Turn-over of RNA and catabolism of nucleotides releases one to four ammonia molecules; the released nutrients being reassimilated into primary metabolism.
Vanessa Jane Melino +8 more
doaj +1 more source