Results 71 to 80 of about 99,634 (353)

An organometallic compound which exhibits a DNA topology-dependent one-stranded intercalation mode [PDF]

, 2016
Understanding how small molecules interact with DNA is essential since it underlies a multitude of pathological conditions and therapeutic interventions.
Adhireksan, Aird, Baruah, Brunk, Chen, Chua, Chua, Davey, Liu, Novakova, Ong, Rescifina, Spingler, Wu, Wu, Wu, Zeglis   +16 more
core   +3 more sources

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Synthesis of Indole Derivatives via Aryl Triazole Ring-Opening and Subsequent Cyclization

Molecules
A metal-free two-step synthetic approach for obtaining indole derivatives from aryl triazole fragment-containing compounds has been developed. In the first step, the Dimroth equilibrium, followed by nitrogen extrusion, Wolff rearrangement, and amine ...
Aleksejs Burcevs, Armands Sebris, Irina Novosjolova, Anatoly Mishnev, Māris Turks   +4 more
doaj   +1 more source

Purine-Furan and Purine-Thiophene Conjugates [PDF]

Molbank, 2018
Furyl and thienyl moieties were introduced into a purine structure to elevate its fluorescence properties, while a trityl group was used to increase the amorphous properties of the purine compounds. The title compounds were prepared by a sequence involving a Mitsunobu, a SNAr and a Suzuki–Miyaura reaction and their photophysical properties were studied.
Zigfrīds Kapilinskis, Irina Novosjolova, Māris Turks   +2 more
openaire   +2 more sources

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source

Infrared absorption spectra of a series of 2, 6-diamino and 2-amino-6hydroxy-8-choroalkyl purines [PDF]

, 2003
8-haloalky purines were synthesized and infrared analysis (IR) carried out on them. The syntheses as well as the ill analyses are reported. The purines synthesized and studied include (i) 2,6-diamin-8-Chloromethyl purines, (ii) 2, 6-diamin-8-chlorethyl
I. M., Ejimadu
core  

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, EarlyView.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

Charge Transfer-oxy Radical Mechanism for Anti-cancer Agents [PDF]

, 1986
The proposal is advanced that anti-cancer drugs generally function by charge transfer resulting in formation of toxic oxy radicals which destroy the neoplasm.
Ames, James R., Cox, O., Elo, Hannu, Kovacic, Peter, Lumme, Paavo, Ryan, Michael D.   +5 more
core   +1 more source

A TDDFT study of the excited states of DNA bases and their assemblies [PDF]

, 2006
We present a detailed study of the optical absorption spectra of DNA bases and base pairs, carried out by means of time dependent density functional theory.
Di Felice, R., Marques, M. A. L., Rubio, A., Varsano, D.   +3 more
core   +2 more sources