Purkinje Cell Patterning-Insights from Single-Cell Sequencing. [PDF]
Cells, 2022 Despite their homogeneous appearance, Purkinje cells are remarkably diverse with respect to their molecular phenotypes, physiological properties, afferent and efferent connectivity, as well as their vulnerability to insults.
Apsley EJ, Becker EBE.
europepmc +5 more sources
Anti-Yo antibody uptake and interaction with its intracellular target antigen causes Purkinje cell death in rat cerebellar slice cultures: a possible mechanism for paraneoplastic cerebellar degeneration in humans with gynecological or breast cancers. [PDF]
PLoS ONE, 2015 Anti-Yo antibodies are immunoglobulin G (IgG) autoantibodies reactive with a 62 kDa Purkinje cell cytoplasmic protein. These antibodies are closely associated with paraneoplastic cerebellar degeneration in the setting of gynecological and breast ...
John E Greenlee +6 more
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Purkinje cell injury, structural plasticity and fusion in patients with Friedreich's ataxia [PDF]
Acta Neuropathologica Communications, 2016 Purkinje cell pathology is a common finding in a range of inherited and acquired cerebellar disorders, with the degree of Purkinje cell injury dependent on the underlying aetiology.
Cook, Amelia +5 more
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eLife, 2020 Tremor is currently ranked as the most common movement disorder. The brain regions and neural signals that initiate the debilitating shakiness of different body parts remain unclear.
Amanda M Brown +5 more
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The sodium-potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron. [PDF]
PLoS ONE, 2012 In vitro, cerebellar Purkinje cells can intrinsically fire action potentials in a repeating trimodal or bimodal pattern. The trimodal pattern consists of tonic spiking, bursting, and quiescence.
Michael D Forrest +3 more
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eLife, 2019 The cerebellum integrates sensory stimuli and motor actions to enable smooth coordination and motor learning. Here we harness the innate behavioral repertoire of the larval zebrafish to characterize the spatiotemporal dynamics of feature coding across ...
Laura D Knogler +2 more
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Modulation, plasticity and pathophysiology of the parallel fiber-Purkinje cell synapse
Frontiers in Synaptic Neuroscience, 2016 The parallel fiber-Purkinje cell synapse represents the point of maximal signal divergence in the cerebellar cortex with an estimated number of about 60 billion synaptic contacts in the rat and 100,000 billions in humans.
Eriola Hoxha +3 more
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Purkinje Cell Loss in Essential Tremor: Collective Data From 215 Brains Over a 21-Year Period. [PDF]
Ann Clin Transl NeurolObjective Essential tremor is a highly prevalent movement disorder. Pathological changes observed in essential tremor cerebella center around Purkinje cells and neighboring neuronal populations.
Kerridge CA +4 more
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Remodeling of monoplanar Purkinje cell dendrites during cerebellar circuit formation.
PLoS ONE, 2011 Dendrite arborization patterns are critical determinants of neuronal connectivity and integration. Planar and highly branched dendrites of the cerebellar Purkinje cell receive specific topographical projections from two major afferent pathways; a single ...
Megumi Kaneko +9 more
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Neurobiology of Disease, 2023 Mitochondrial deficits have been observed in animal models of Autosomal-recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) and in patient-derived fibroblasts. We investigated whether mitochondrial function could be restored in Sacs−/− mice, a mouse
Brenda Toscano Márquez +5 more
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