Results 141 to 150 of about 80,189 (259)

Using cerebellar Purkinje cell models at different levels of abstraction as a read-out mechanism for pattern recognition in a biologically detailed granular layer model [PDF]

, 2019
Davey, Neil, Kadir, Shabnam, Katakura, Ohki, Maex, Reinoud, Steuber, Volker   +4 more
core   +2 more sources

Longer action potential duration in the Purkinje network than in the ventricular myocardium delays retrograde activation of the human His‐Purkinje system

The Journal of Physiology, EarlyView.
Abstract figure legend Activation time (AT) maps from right ventricular apical pacing in a human ventricles model with longer action potential duration in the His‐Purkinje system (HPS) than in the myocardium (MYO). For pacing with a long S1S2 coupling interval (CI), the AT from the myocardial pacing site to the first AT of the HPS (ATMYO) is longer ...
Jason D. Bayer, Edward J. Vigmond, Ruben Coronel, Chantal E. Conrath   +3 more
wiley   +1 more source

Combination Versus Monotherapy in Acute Anti‐LGI1 Encephalitis: A Real‐World Dose Optimization Analysis

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
Combined IVIg and 500 mg/day IVMP achieve superior efficacy over monotherapies in anti‐LGI1 encephalitis, with optimal safety. Higher‐dose IVMP (1000 mg) accelerates response but increases adverse events, particularly in diabetic patients. Cognitive deficits persist post‐treatment, necessitating long‐term management.
Yao Tan, Ming Sun, Qinqin Liu, Beibei Huang, Chao Wu, Jie Lu, Donglin Zhu   +6 more
wiley   +1 more source

Purkinje Cell [PDF]

, 2020
openaire   +1 more source

A CACNA2D2‐Related Recessive Form of Cerebellar Abiotrophy in Angus Cattle

Animal Genetics, Volume 57, Issue 2, April 2026.
ABSTRACT Cerebellar disease in ruminants is often virus‐induced and non‐genetic, but there are also rare inherited forms of cerebellar hypoplasia and cerebellar abiotrophy (CA). So far, no causal variant has been reported for these conditions in cattle. Two inbred Angus calves suspected of having cerebellar disease were reported in Scotland.
Joana Jacinto, Francesca Chianini, Jo Moore, Timothy Geraghty, Irene M. Häfliger, Franz R. Seefried, Alwyn Jones, Helen Carty, Anna Letko, Cord Drögemüller   +9 more
wiley   +1 more source

Human Brain Contusions Contain Pathogenic Transmissible Species that Induce Progressive Cognitive Decline and Tau Pathology in Mice

Annals of Neurology, Volume 99, Issue 4, Page 897-911, April 2026.
Objective Traumatic brain injury (TBI) is an established risk factor for dementia, although the underlying mechanisms remain unclear. Our previous research demonstrated that a single severe TBI in wild‐type (WT) mice induces a prion‐like form of tau (tauTBI) that spreads throughout the brain, leading to memory deficits.
Gloria Vegliante, Francesca Pischiutta, Elena Restelli, Federico Moro, Maria Antonietta Chiaravalloti, Ilaria Raimondi, Ilaria Bertani, Ilaria Lisi, Eliana Sammali, Rosaria Pascente, Serena Scozzari, Laura Pasetto, Carly Douglas, Marco Locatelli, Fabrizio Ortolano, Valentina Bonetto, David J. Loane, Nino Stocchetti, Roberto Chiesa, Elisa R. Zanier   +19 more
wiley   +1 more source

Astrocytes as central integrators of neural circuit function: Mechanisms and dysregulation in neuropsychiatric disorders

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
1. Astrocytes are central integrators of neural circuit function through tripartite synapse modulation and neurovascular coupling. 2. Dysregulation of glutamate/GABA homeostasis and neuroinflammation represents shared mechanisms across diverse neuropsychiatric disorders. 3.
Xinyu Liu, Xinyue Zhou, Ruotong Meng, Yanxi Chen, You Chen, Blake Highet, Maurice Curtis, Bernhard Hirt, Shunying Yu, Jin Zhou, Linya You   +10 more
wiley   +1 more source

VGLUT1 and PSD‐95 Expression Remains Stable in the Prefrontal and Cerebellar Cortices of the VPA Autism Rat Model

Developmental Neurobiology, Volume 86, Issue 2, April 2026.
ABSTRACT Autism spectrum disorder (ASD) has recently been described as a synaptopathy where dysregulation at the level of the synapse is thought to evoke an excitation–inhibition (E/I) imbalance implicated in its pathogenesis. The mechanisms through which alterations in glutamatergic signaling bring about an E/I imbalance remain elusive.
Megan Reveley, Gavin Ray Owen, Nancy Tumba, Oladiran Ibukunolu Olateju, Busisiwe Constance Maseko   +4 more
wiley   +1 more source

Neuronal Activity Promotes Node‐Like Cluster Assembly Prior to Myelination and Remyelination in the Central Nervous System

Glia, Volume 74, Issue 4, April 2026.
Ronzano et al. show that neuronal activity promotes node‐like cluster (NLC) formation before (re)myelination by regulating β1Nav and Nav1.1, which are essential for NLC assembly. This may represent an intermediate step in activity‐driven myelination and contribute to the regulation of axonal conduction.
Rémi Ronzano, Clément Perrot, Elisa Mazuir, Melina Thetiot, Marie‐Stéphane Aigrot, Paul Stheneur, François‐Xavier Lejeune, Bruno Stankoff, Catherine Lubetzki, Nathalie Sol‐Foulon, Anne Desmazières   +10 more
wiley   +1 more source

Cerebellar purkinje cell dysfunction contributes to gait impairments in Shank3-mutant mice. [PDF]

Mol Autism
Liu H, Huang X, Ma G, Zhao X, Xia R, Li Z, Guo B, Wu S, Wang W.   +8 more
europepmc   +1 more source