Results 11 to 20 of about 80,189 (259)

Purkinje Cell Patterning—Insights from Single-Cell Sequencing

Cells, 2022
Despite their homogeneous appearance, Purkinje cells are remarkably diverse with respect to their molecular phenotypes, physiological properties, afferent and efferent connectivity, as well as their vulnerability to insults.
Elizabeth J. Apsley, Esther B. E. Becker
doaj   +4 more sources

Human Purkinje cells outperform mouse Purkinje cells in dendritic complexity and computational capacity

Communications Biology
Purkinje cells in the cerebellum are among the largest neurons in the brain and have been extensively investigated in rodents. However, their morphological and physiological properties remain poorly understood in humans.
Stefano Masoli, Diana Sanchez-Ponce, Nora Vrieler, Karin Abu-Haya, Vitaly Lerner, Tal Shahar, Hermina Nedelescu, Martina Francesca Rizza, Ruth Benavides-Piccione, Javier DeFelipe, Yosef Yarom, Alberto Munoz, Egidio D’Angelo   +12 more
doaj   +7 more sources

Optimizing Optogenetic Activation of Purkinje Cell Axons to Investigate the Purkinje Cell – DCN Synapse

Frontiers in Synaptic Neuroscience, 2019
Optogenetics is a state-of-the-art tool for interrogating neural circuits. In the cerebellum, Purkinje cells serve as the sole output of the cerebellar cortex where they synapse on neurons in the deep cerebellar nuclei (DCN).
Kim M. Gruver, Kim M. Gruver, Alanna J. Watt   +2 more
doaj   +3 more sources

Purkinje Cell Loss in Essential Tremor: Collective Data From 215 Brains Over a 21-Year Period. [PDF]

Ann Clin Transl Neurol
Objective Essential tremor is a highly prevalent movement disorder. Pathological changes observed in essential tremor cerebella center around Purkinje cells and neighboring neuronal populations.
Kerridge CA, Hernandez RS, Hernandez NC, Faust PL, Louis ED.   +4 more
europepmc   +2 more sources

Anti-Yo antibody uptake and interaction with its intracellular target antigen causes Purkinje cell death in rat cerebellar slice cultures: a possible mechanism for paraneoplastic cerebellar degeneration in humans with gynecological or breast cancers. [PDF]

PLoS ONE, 2015
Anti-Yo antibodies are immunoglobulin G (IgG) autoantibodies reactive with a 62 kDa Purkinje cell cytoplasmic protein. These antibodies are closely associated with paraneoplastic cerebellar degeneration in the setting of gynecological and breast ...
John E Greenlee, Susan A Clawson, Kenneth E Hill, Blair Wood, Stacey L Clardy, Ikuo Tsunoda, Noel G Carlson   +6 more
doaj   +1 more source

A mitochondrial-targeted antioxidant (MitoQ) improves motor coordination and reduces Purkinje cell death in a mouse model of ARSACS

Neurobiology of Disease, 2023
Mitochondrial deficits have been observed in animal models of Autosomal-recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) and in patient-derived fibroblasts. We investigated whether mitochondrial function could be restored in Sacs−/− mice, a mouse
Brenda Toscano Márquez, Tsz Chui Sophia Leung, Jeanette Hui, François Charron, R. Anne McKinney, Alanna J. Watt   +5 more
doaj   +1 more source

Molecular Identity and Location Influence Purkinje Cell Vulnerability in Autosomal-Recessive Spastic Ataxia of Charlevoix-Saguenay Mice

Frontiers in Cellular Neuroscience, 2021
Patterned cell death is a common feature of many neurodegenerative diseases. In patients with autosomal-recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) and mouse models of ARSACS, it has been observed that Purkinje cells in anterior cerebellar ...
Brenda Toscano Márquez, Anna A. Cook, Max Rice, Alexia Smileski, Kristen Vieira-Lomasney, François Charron, R. Anne McKinney, Alanna J. Watt   +7 more
doaj   +1 more source

A computational passage-of-time model of the cerebellar Purkinje cell in eyeblink conditioning

Frontiers in Computational Neuroscience, 2023
The cerebellar Purkinje cell controlling eyeblinks can learn, remember, and reproduce the interstimulus interval in a classical conditioning paradigm. Given temporally separated inputs, the cerebellar Purkinje cell learns to pause its tonic inhibition of
Matthew Ricci, Junkyung Kim, Fredrik Johansson   +2 more
doaj   +1 more source

Purkinje cell neurotransmission patterns cerebellar basket cells into zonal modules defined by distinct pinceau sizes

eLife, 2020
Ramón y Cajal proclaimed the neuron doctrine based on circuit features he exemplified using cerebellar basket cell projections. Basket cells form dense inhibitory plexuses that wrap Purkinje cell somata and terminate as pinceaux at the initial segment of
Joy Zhou, Amanda M Brown, Elizabeth P Lackey, Marife Arancillo, Tao Lin, Roy V Sillitoe   +5 more
doaj   +1 more source

Differential synapse density between Purkinje cell dendritic spine and parallel fiber varicosity in the rat cerebellum among the phylogenic lobules

Applied Microscopy, 2020
The cerebellum is a region of the brain that plays an important role in motor control. It is classified phylogenetically into archicerebellum, paleocerebellum and neocerebellum.
Hyun-Wook Kim, Seung Hak Oh, Se Jeong Lee, Ji eun Na, Im Joo Rhyu   +4 more
doaj   +1 more source