Results 11 to 20 of about 10,772,524 (242)

Purkinje cell stripes and long-term depression at the parallel fiber-Purkinje cell synapse [PDF]

Frontiers in Systems Neuroscience, 2014
The cerebellar cortex comprises a stereotyped array of transverse zones and parasagittal stripes, built around multiple Purkinje cell subtypes, which is highly conserved across birds and mammals. This architecture is revealed in the restricted expression
R. Hawkes
semanticscholar   +5 more sources

Optimizing Optogenetic Activation of Purkinje Cell Axons to Investigate the Purkinje Cell – DCN Synapse

Frontiers in Synaptic Neuroscience, 2019
Optogenetics is a state-of-the-art tool for interrogating neural circuits. In the cerebellum, Purkinje cells serve as the sole output of the cerebellar cortex where they synapse on neurons in the deep cerebellar nuclei (DCN).
Kim M. Gruver, Kim M. Gruver, Alanna J. Watt   +2 more
doaj   +3 more sources

Human Purkinje cells outperform mouse Purkinje cells in dendritic complexity and computational capacity

Communications Biology
Purkinje cells in the cerebellum are among the largest neurons in the brain and have been extensively investigated in rodents. However, their morphological and physiological properties remain poorly understood in humans.
Stefano Masoli, Diana Sanchez-Ponce, Nora Vrieler, Karin Abu-Haya, Vitaly Lerner, Tal Shahar, Hermina Nedelescu, Martina Francesca Rizza, Ruth Benavides-Piccione, Javier DeFelipe, Yosef Yarom, Alberto Munoz, Egidio D’Angelo   +12 more
doaj   +7 more sources

Purkinje Cell [PDF]

Definitions, 2020

semanticscholar   +2 more sources

Losing the Beat: Contribution of Purkinje Cell Firing Dysfunction to Disease, and Its Reversal

Neuroscience, 2020
The cerebellum is a brain structure that is highly interconnected with other brain regions. There are many contributing factors to cerebellar-related brain disease, such as altered afferent input, local connectivity, and/or cerebellar output.
Anna A. Cook, Eviatar Fields, A. Watt
semanticscholar   +1 more source

Serotonin drives a novel GABAergic synaptic current recorded in rat cerebellar purkinje cells: a lugaro cell to Purkinje cell synapse [PDF]

, 2003
We recorded a novel fast GABAergic synaptic current in cerebellar Purkinje cells in rat brain slices using patch-clamp techniques. Because of a relatively low sensitivity to bicuculline, these currents can be recorded under conditions in which basket ...
Dean, I., Edwards, F.A., Robertson, S.J.
core   +3 more sources

Cerebellar Purkinje cell activity modulates aggressive behavior

bioRxiv, 2020
Although the cerebellum is traditionally associated with balance and motor function, it also plays wider roles in affective and cognitive behaviors. Evidence suggests that the cerebellar vermis may regulate aggressive behavior, though the cerebellar ...
Skyler L. Jackman, Christopher H. Chen, Heather L Offermann, Iain R. Drew, Bailey M Harrison, Anna M. Bowman, K. Flick, Isabella Flaquer, W. Regehr   +8 more
semanticscholar   +1 more source

Molecular Identity and Location Influence Purkinje Cell Vulnerability in Autosomal-Recessive Spastic Ataxia of Charlevoix-Saguenay Mice

Frontiers in Cellular Neuroscience, 2021
Patterned cell death is a common feature of many neurodegenerative diseases. In patients with autosomal-recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) and mouse models of ARSACS, it has been observed that Purkinje cells in anterior cerebellar ...
Brenda Toscano Márquez, Anna A. Cook, Max Rice, Alexia Smileski, Kristen Vieira-Lomasney, François Charron, R. Anne McKinney, Alanna J. Watt   +7 more
doaj   +1 more source

A computational passage-of-time model of the cerebellar Purkinje cell in eyeblink conditioning

Frontiers in Computational Neuroscience, 2023
The cerebellar Purkinje cell controlling eyeblinks can learn, remember, and reproduce the interstimulus interval in a classical conditioning paradigm. Given temporally separated inputs, the cerebellar Purkinje cell learns to pause its tonic inhibition of
Matthew Ricci, Junkyung Kim, Fredrik Johansson   +2 more
doaj   +1 more source

Purkinje cell neurotransmission patterns cerebellar basket cells into zonal modules defined by distinct pinceau sizes

eLife, 2020
Ramón y Cajal proclaimed the neuron doctrine based on circuit features he exemplified using cerebellar basket cell projections. Basket cells form dense inhibitory plexuses that wrap Purkinje cell somata and terminate as pinceaux at the initial segment of
Joy Zhou, Amanda M Brown, Elizabeth P Lackey, Marife Arancillo, Tao Lin, Roy V Sillitoe   +5 more
doaj   +1 more source