Results 31 to 40 of about 80,189 (259)
Fear conditioning-related changes in cerebellar Purkinje cell activities in goldfish
Behavioral and Brain Functions, 2012 Background Fear conditioning-induced changes in cerebellar Purkinje cell responses to a conditioned stimulus have been reported in rabbits. It has been suggested that synaptic long-term potentiation and the resulting increases in firing rates of Purkinje
Yoshida Masayuki, Kondo Hiroki
doaj +1 more source
eLife, 2020 Tremor is currently ranked as the most common movement disorder. The brain regions and neural signals that initiate the debilitating shakiness of different body parts remain unclear.
Amanda M Brown +5 more
doaj +1 more source
Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation.
PLoS Computational Biology, 2019 Cerebellar Purkinje cells mediate accurate eye movement coordination. However, it remains unclear how oculomotor adaptation depends on the interplay between the characteristic Purkinje cell response patterns, namely tonic, bursting, and spike pauses ...
Niceto R Luque +4 more
doaj +1 more source
Studying cerebellar circuits by remote control of selected neuronal types with GABA-A receptors
Frontiers in Molecular Neuroscience, 2009 Although GABA-A receptor-mediated inhibition of cerebellar Purkinje cells by molecular layer interneurons (MLIs) has been studied intensely on the cellular level, it has remained unclear how this inhibition regulates cerebellum-dependent behaviour.
William Wisden +3 more
doaj +1 more source
Purkinje Cells Pathology in Alzheimer’s Disease [PDF]
American Journal of Alzheimer's Disease & Other Dementias®, 2019 Alzheimer’s disease (AD) is one of the main causes of dementia in senium and presenium. It is clinically characterized by memory impairment, deterioration of intellectual faculties, and loss of professional skills. The cerebellum is a critical part in the distributed neural circuits participating not only in motor function but also in autonomic ...
Ioannis Mavroudis +5 more
openaire +2 more sources
Temporal properties of cerebellar-dependent memory consolidation [PDF]
, 2004 Classical conditioning of the nictitating membrane response in rabbits is a well defined model of cerebellar-dependent motor memory. This memory undergoes a period of consolidation after the training session, when it is sensitive to reversible ...
Attwell, PJE, Cooke, SF, Yeo, CH
core +1 more source
Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degeneration
Neurobiology of Disease, 2011 Tuberous sclerosis complex (TSC) is a neurogenetic disorder that often causes brain abnormalities leading to epilepsy, developmental delay, and autism.
R. Michelle Reith +4 more
doaj +1 more source
Angewandte Chemie, EarlyView.We here developed a molecular tool for the optical control of UGGAA repeat RNA foci, a pathological hallmark of spinocerebellar ataxia type 31 (SCA31). The photoswitchable RNA‐binding ligand enabled reversible control of the RNA foci. UV irradiation induced the growth of the RNA foci, while subsequent visible light irradiation dissolved the structure ...
Yusuke Fujiwara +2 more
wiley +2 more sources
Trehalose alleviates the phenotype of Machado–Joseph disease mouse models [PDF]
, 2020 Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 aggregation and neuronal degeneration.
Cavadas, Cláudia +10 more
core +1 more source
Neurobiology of Disease, 2011 Alteration in mitochondrial dynamics has been implicated in many neurodegenerative diseases. Mitochondrial apoptosis inducing factor (AIF) plays a key role in multiple cellular and disease processes.
Seung-Hyuk Chung +4 more
doaj +1 more source