Results 41 to 50 of about 10,772,524 (242)
Population-scale organization of cerebellar granule neuron signaling during a visuomotor behavior. [PDF]
, 2017 Granule cells at the input layer of the cerebellum comprise over half the neurons in the human brain and are thought to be critical for learning. However, little is known about granule neuron signaling at the population scale during behavior.
Aksay, Emre RF +5 more
core +2 more sources
Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation.
PLoS Computational Biology, 2019 Cerebellar Purkinje cells mediate accurate eye movement coordination. However, it remains unclear how oculomotor adaptation depends on the interplay between the characteristic Purkinje cell response patterns, namely tonic, bursting, and spike pauses ...
Niceto R Luque +4 more
doaj +1 more source
Temporal properties of cerebellar-dependent memory consolidation [PDF]
, 2004 Classical conditioning of the nictitating membrane response in rabbits is a well defined model of cerebellar-dependent motor memory. This memory undergoes a period of consolidation after the training session, when it is sensitive to reversible ...
Attwell, PJE, Cooke, SF, Yeo, CH
core +1 more source
Nitric oxide and synaptic function [PDF]
, 1994 The free radical gas nitric oxide (NO) is a recently identified neuronal messenger that carries out diverse signaling tasks in both the central and peripheral nervous systems.
Madison, Daniel V., Schuman, Erin M.
core +1 more source
Purkinje Cells Pathology in Alzheimer’s Disease [PDF]
American Journal of Alzheimer's Disease & Other Dementias®, 2019 Alzheimer’s disease (AD) is one of the main causes of dementia in senium and presenium. It is clinically characterized by memory impairment, deterioration of intellectual faculties, and loss of professional skills. The cerebellum is a critical part in the distributed neural circuits participating not only in motor function but also in autonomic ...
Ioannis Mavroudis +5 more
openaire +2 more sources
Studying cerebellar circuits by remote control of selected neuronal types with GABA-A receptors
Frontiers in Molecular Neuroscience, 2009 Although GABA-A receptor-mediated inhibition of cerebellar Purkinje cells by molecular layer interneurons (MLIs) has been studied intensely on the cellular level, it has remained unclear how this inhibition regulates cerebellum-dependent behaviour.
William Wisden +3 more
doaj +1 more source
Neurobiology of Disease, 2011 Alteration in mitochondrial dynamics has been implicated in many neurodegenerative diseases. Mitochondrial apoptosis inducing factor (AIF) plays a key role in multiple cellular and disease processes.
Seung-Hyuk Chung +4 more
doaj +1 more source
Are Purkinje Cell Pauses Drivers of Classically Conditioned Blink Responses?
Cerebellum, 2015 Several lines of evidence show that classical or Pavlovian conditioning of blink responses depends on the cerebellum. Recordings from cerebellar Purkinje cells that control the eyelid and the conditioned blink show that during training with a ...
Dan-Anders Jirenhed, G. Hesslow
semanticscholar +1 more source
Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degeneration
Neurobiology of Disease, 2011 Tuberous sclerosis complex (TSC) is a neurogenetic disorder that often causes brain abnormalities leading to epilepsy, developmental delay, and autism.
R. Michelle Reith +4 more
doaj +1 more source
Firing Dynamics of Cerebellar Purkinje Cells [PDF]
Journal of Neurophysiology, 2007 Knowledge of intrinsic neuronal firing dynamics is a critical first step to establishing an accurate biophysical model of any neuron. In this study we examined cerebellar Purkinje cells to determine the bifurcations likely to underlie firing dynamics within a biophysically realistic and experimentally supported model.
Fernando R, Fernandez +2 more
openaire +2 more sources