Results 71 to 80 of about 10,772,524 (242)

Effect of intrauterine morphine sulfate exposure on cerebellar histomorphological changes in neonatal mice [PDF]

, 2011
Neurotoxic effects of morphine sulfate in adult cerebellar cortex and neonatal cerebral cortex have been studied in animal models. This study was done to determine the neurotoxic effects of prenatal morphine exposure on the histo morphological changes of
Ghafari, S., Golalipour, M.J., Roshandel, D.   +2 more
core  

Coding of stimulus strength via analog calcium signals in Purkinje cell dendrites of awake mice

eLife, 2014
The climbing fiber input to Purkinje cells acts as a teaching signal by triggering a massive influx of dendritic calcium that marks the occurrence of instructive stimuli during cerebellar learning.
Farzaneh Najafi, Andrea Giovannucci, S. Wang, J. Medina   +3 more
semanticscholar   +1 more source

The Reelin receptors Apoer2 and Vldlr coordinate the patterning of Purkinje cell topography in the developing mouse cerebellum. [PDF]

PLoS ONE, 2008
The adult cerebellar cortex is comprised of reproducible arrays of transverse zones and parasagittal stripes of Purkinje cells. Adult stripes are created through the perinatal rostrocaudal dispersion of embryonic Purkinje cell clusters, triggered by ...
Matt Larouche, Uwe Beffert, Joachim Herz, Richard Hawkes   +3 more
doaj   +1 more source

Direct reprogramming of cardiomyocytes into cardiac Purkinje-like cells

iScience, 2022
Summary: Currently, there are no treatments that ameliorate cardiac cell death, the underlying basis of cardiovascular disease. An unexplored cell type in cardiac regeneration is cardiac Purkinje cells; specialized cells from the cardiac conduction ...
Nicole Prodan, Faheem Ershad, Arfaxad Reyes-Alcaraz, Luge Li, Brandon Mistretta, Lei Gonzalez, Zhoulyu Rao, Cunjiang Yu, Preethi H. Gunaratne, Na Li, Robert J. Schwartz, Bradley K. McConnell   +11 more
doaj   +1 more source

Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome [PDF]

, 2009
Down syndrome (DS) is a genetic disorder arising from the presence of a third copy of human chromosome 21 (Hsa21). Recently, O’Doherty et al. [An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. Science 309 (2005) 2033–
Bliss, T.V.P., Daniel, H., Fisher, E.M.C., Galante, M., Jani, H., Morice, E., Tybulewicz, V.L.J., Vanes, L.   +7 more
core   +3 more sources

Attentive Learning of Sequential Handwriting Movements: A Neural Network Model [PDF]

, 2000
Defense Advanced research Projects Agency and the Office of Naval Research (N00014-95-1-0409, N00014-92-J-1309); National Science Foundation (IRI-97-20333); National Institutes of Health (I-R29-DC02952-01)
A. Berardelli, A. Dagher, A. Thomassen, A. Thomassen, A.B. Schwartz, A.P. Georgopoulos, A.P. Georgopoulos, A.P. Georgopoulos, A.P. Georgopoulos, A.W. Gemmert van, B.D. Kretschmer, C. Fowler, C. Ghez, C.E. Wright, D. Bullock, D. Bullock, D. Bullock, D. Bullock, D. Bullock, D. Bullock, D. Ostry, D. Zipser, D.M. Bannerman, D.V. Buonomano, E. Bizzi, E.M. Arroyo-Anllo, F. Chapeau-Blondeau, F. Lacquaniti, F. Mussa-Ivaldi, F. Richer, F.B. Horak, F.B. Horak, F.N. Freeman, G.P. Galen van, G.P. Galen van, G.T. Bartha, I. Hertrich, J. Alston, J. Doyon, J. Fiala, J. Schillings, J. Soechting, J. Wann, J.A. Freeman, J.B. Hopfinger, J.D. Coltz, J.D. Coltz, J.F. Kalaska, J.I. Simpson, J.J. Waite, J.M. Hollerbach, J.P. Wann, J.W. Moore, K. Greer, M. Hallett, M. Iacoboni, M. Ito, M. Ito, M. Ito, M. Jueptner, M. Jueptner, M. Jueptner, M.G. Pleskacheva, M.T. Turvey, N. Bernstein, N. Sadato, O. Oscarsson, P. Morasso, P. Morasso, P. Morasso, P. Vindras, P.C. Burns, Q.G. Fu, R. Andersen, R. Andersen, R. Caminiti, R. Gellman, R. Kawashima, R. Plamondon, R.S. Turner, R.S. Turner, S. Chieffi, S. Edelman, S. Grossberg, S. Grossberg, S. Grossberg, S. Jaffe, S. Ohman, S.P. Perrett, T.J. Ebner, T.L. Zhou, T.S. Buchanan, W. Abend, X. Lu   +93 more
core   +2 more sources

Ataxic phenotype with altered CaV3.1 channel property in a mouse model for spinocerebellar ataxia 42

Neurobiology of Disease, 2019
Spinocerebellar ataxia 42 (SCA42) is a neurodegenerative disorder recently shown to be caused by c.5144G > A (p.Arg1715His) mutation in CACNA1G, which encodes the T-type voltage-gated calcium channel CaV3.1. Here, we describe a large Japanese family with
Shunta Hashiguchi, Hiroshi Doi, Misako Kunii, Yukihiro Nakamura, Misa Shimuta, Etsuko Suzuki, Shigeru Koyano, Masaki Okubo, Hitaru Kishida, Masaaki Shiina, Kazuhiro Ogata, Fumiko Hirashima, Yukichi Inoue, Shun Kubota, Noriko Hayashi, Haruko Nakamura, Keita Takahashi, Atsuko Katsumoto, Mikiko Tada, Kenichi Tanaka, Toshikuni Sasaoka, Satoko Miyatake, Noriko Miyake, Hirotomo Saitsu, Nozomu Sato, Kokoro Ozaki, Kiyobumi Ohta, Takanori Yokota, Hidehiro Mizusawa, Jun Mitsui, Hiroyuki Ishiura, Jun Yoshimura, Shinichi Morishita, Shoji Tsuji, Hideyuki Takeuchi, Kinya Ishikawa, Naomichi Matsumoto, Taro Ishikawa, Fumiaki Tanaka   +38 more
doaj   +1 more source

Eph/ephrin Function Contributes to the Patterning of Spinocerebellar Mossy Fibers Into Parasagittal Zones

Frontiers in Systems Neuroscience, 2020
Purkinje cell microcircuits perform diverse functions using widespread inputs from the brain and spinal cord. The formation of these functional circuits depends on developmental programs and molecular pathways that organize mossy fiber afferents from ...
Elizabeth P. Lackey, Elizabeth P. Lackey, Elizabeth P. Lackey, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe   +7 more
doaj   +1 more source

Logarithmic distributions prove that intrinsic learning is Hebbian

, 2017
In this paper, we present data for the lognormal distributions of spike rates, synaptic weights and intrinsic excitability (gain) for neurons in various brain areas, such as auditory or visual cortex, hippocampus, cerebellum, striatum, midbrain nuclei ...
Scheler, Gabriele
core   +2 more sources

ATXN2-CAG42 sequesters PABPC1 into insolubility and induces FBXW8 in cerebellum of old ataxic knock-in mice [PDF]

, 2012
Spinocerebellar Ataxia Type 2 (SCA2) is caused by expansion of a polyglutamine encoding triplet repeat in the human ATXN2 gene beyond (CAG)31. This is thought to mediate toxic gain-of-function by protein aggregation and to affect RNA processing ...
Auburger, Georg, Azizov, Mekhman, Damrath, Ewa, Gispert, Suzana, Heck, Melanie V., Nowock, Joachim, Rüb, Udo, Seifried, Carola, Walter, Michael   +8 more
core   +3 more sources