Results 71 to 80 of about 80,189 (259)

Direct reprogramming of cardiomyocytes into cardiac Purkinje-like cells

iScience, 2022
Summary: Currently, there are no treatments that ameliorate cardiac cell death, the underlying basis of cardiovascular disease. An unexplored cell type in cardiac regeneration is cardiac Purkinje cells; specialized cells from the cardiac conduction ...
Nicole Prodan, Faheem Ershad, Arfaxad Reyes-Alcaraz, Luge Li, Brandon Mistretta, Lei Gonzalez, Zhoulyu Rao, Cunjiang Yu, Preethi H. Gunaratne, Na Li, Robert J. Schwartz, Bradley K. McConnell   +11 more
doaj   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Purkinje cell stripes and long-term depression at the parallel fiber-Purkinje cell synapse [PDF]

Frontiers in Systems Neuroscience, 2014
Article deposited according to Frontiers policy for Frontiers in Systems Neuroscience: http://www.frontiersin.org/about/faq June 18 ...
openaire   +4 more sources

Ataxic phenotype with altered CaV3.1 channel property in a mouse model for spinocerebellar ataxia 42

Neurobiology of Disease, 2019
Spinocerebellar ataxia 42 (SCA42) is a neurodegenerative disorder recently shown to be caused by c.5144G > A (p.Arg1715His) mutation in CACNA1G, which encodes the T-type voltage-gated calcium channel CaV3.1. Here, we describe a large Japanese family with
Shunta Hashiguchi, Hiroshi Doi, Misako Kunii, Yukihiro Nakamura, Misa Shimuta, Etsuko Suzuki, Shigeru Koyano, Masaki Okubo, Hitaru Kishida, Masaaki Shiina, Kazuhiro Ogata, Fumiko Hirashima, Yukichi Inoue, Shun Kubota, Noriko Hayashi, Haruko Nakamura, Keita Takahashi, Atsuko Katsumoto, Mikiko Tada, Kenichi Tanaka, Toshikuni Sasaoka, Satoko Miyatake, Noriko Miyake, Hirotomo Saitsu, Nozomu Sato, Kokoro Ozaki, Kiyobumi Ohta, Takanori Yokota, Hidehiro Mizusawa, Jun Mitsui, Hiroyuki Ishiura, Jun Yoshimura, Shinichi Morishita, Shoji Tsuji, Hideyuki Takeuchi, Kinya Ishikawa, Naomichi Matsumoto, Taro Ishikawa, Fumiaki Tanaka   +38 more
doaj   +1 more source

The Marr and Albus Theories of the Cerebellum: Two Eary Models of Associative Memory [PDF]

, 1989
The Marr and Albus theories of the cerebellum are compared and contrasted. They are shown to be similar in their analysis of the function of the mossy fibers, granule cells, Golgi cells, and Purkinje cells.
Albus, James S.
core   +1 more source

PSD-95 Is Associated with the Postsynaptic Density and Not with the Presynaptic Membrane at Forebrain Synapses [PDF]

, 1996
PSD-95, a prominent protein component of the postsynaptic density (PSD) fraction from rat forebrain, has been localized by light microscopy to dendrites of hippocampal neurons (Cho et al., 1992) and to the presynaptic plexus of cerebellar basket cells ...
Hunt, Carol A., Kennedy, Mary B., Schenker, Leslie J.   +2 more
core   +1 more source

Eph/ephrin Function Contributes to the Patterning of Spinocerebellar Mossy Fibers Into Parasagittal Zones

Frontiers in Systems Neuroscience, 2020
Purkinje cell microcircuits perform diverse functions using widespread inputs from the brain and spinal cord. The formation of these functional circuits depends on developmental programs and molecular pathways that organize mossy fiber afferents from ...
Elizabeth P. Lackey, Elizabeth P. Lackey, Elizabeth P. Lackey, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe   +7 more
doaj   +1 more source

Hominoid‐specific calretinin‐immunopositivity of the optic radiation (geniculocalcarine tract)

The Anatomical Record, EarlyView.
Calretinin‐immunostained coronal section through the primary (V1) and extrastriate (ExSt) cortex of the lar gibbon. Note that the optic radiation (OR) is strongly calretinin‐immunoreactive. This calretinin‐immunopositivity of the OR distinguishes the Hominoidea from other primates in terms of the neurochemistry of the OR.
Nelyane N. M. Santana, Jordan Swiegers, Mads F. Bertelsen, Chet C. Sherwood, José R. L. P. Cavalcanti, Paul R. Manger   +5 more
wiley   +1 more source

Attentive Learning of Sequential Handwriting Movements: A Neural Network Model [PDF]

, 2000
Defense Advanced research Projects Agency and the Office of Naval Research (N00014-95-1-0409, N00014-92-J-1309); National Science Foundation (IRI-97-20333); National Institutes of Health (I-R29-DC02952-01)
A. Berardelli, A. Dagher, A. Thomassen, A. Thomassen, A.B. Schwartz, A.P. Georgopoulos, A.P. Georgopoulos, A.P. Georgopoulos, A.P. Georgopoulos, A.W. Gemmert van, B.D. Kretschmer, C. Fowler, C. Ghez, C.E. Wright, D. Bullock, D. Bullock, D. Bullock, D. Bullock, D. Bullock, D. Bullock, D. Ostry, D. Zipser, D.M. Bannerman, D.V. Buonomano, E. Bizzi, E.M. Arroyo-Anllo, F. Chapeau-Blondeau, F. Lacquaniti, F. Mussa-Ivaldi, F. Richer, F.B. Horak, F.B. Horak, F.N. Freeman, G.P. Galen van, G.P. Galen van, G.T. Bartha, I. Hertrich, J. Alston, J. Doyon, J. Fiala, J. Schillings, J. Soechting, J. Wann, J.A. Freeman, J.B. Hopfinger, J.D. Coltz, J.D. Coltz, J.F. Kalaska, J.I. Simpson, J.J. Waite, J.M. Hollerbach, J.P. Wann, J.W. Moore, K. Greer, M. Hallett, M. Iacoboni, M. Ito, M. Ito, M. Ito, M. Jueptner, M. Jueptner, M. Jueptner, M.G. Pleskacheva, M.T. Turvey, N. Bernstein, N. Sadato, O. Oscarsson, P. Morasso, P. Morasso, P. Morasso, P. Vindras, P.C. Burns, Q.G. Fu, R. Andersen, R. Andersen, R. Caminiti, R. Gellman, R. Kawashima, R. Plamondon, R.S. Turner, R.S. Turner, S. Chieffi, S. Edelman, S. Grossberg, S. Grossberg, S. Grossberg, S. Jaffe, S. Ohman, S.P. Perrett, T.J. Ebner, T.L. Zhou, T.S. Buchanan, W. Abend, X. Lu   +93 more
core   +2 more sources

Mild Cerebellar Neurodegeneration of Aged Heterozygous PCD Mice Increases Cell Fusion of Purkinje and Bone Marrow-Derived Cells

Cell Transplantation, 2012
Bone marrow-derived cells have different plastic properties, especially regarding cell fusion, which increases with time and is prompted by tissue injury.
David Díaz, Javier S. Recio, Eduardo Weruaga, Jose R. Alonso   +3 more
doaj   +1 more source