Results 91 to 100 of about 4,781,201 (273)

Specification of Granule Cells and Purkinje Cells.

open access: yes, 2021
Granule cells and Purkinje cells are the major populations of neurons in the cerebellum. Their specification depends on a combination of regional identity and spatiotemporal cues.
Rook, Victoria   +4 more
core   +1 more source

Non‐Alzheimer Aβ deposits in the human CNS: Implications with hypoxia and related conditions

open access: yesBrain Pathology, EarlyView.
An Aβ deposit in a non‐Alzheimer's brain from an individual who experienced hypoxia/energy failure. Abstract We recently reported the deposition of Aβ in the frontal cortex of individuals who died of acute coronavirus disease 2019 (COVID‐19), or who did not have COVID‐19 but had respiratory distress, or infants with severe cardiac malformations.
Esma Karlovich   +5 more
wiley   +1 more source

Reading out a spatiotemporal population code by imaging neighbouring parallel fibre axons in vivo. [PDF]

open access: yes, 2015
The spatiotemporal pattern of synaptic inputs to the dendritic tree is crucial for synaptic integration and plasticity. However, it is not known if input patterns driven by sensory stimuli are structured or random.
Wilms, CD, Häusser, M
core  

Chronic traumatic encephalopathy in a neuropathologically confirmed Creutzfeldt–Jakob disease cohort

open access: yesBrain Pathology, EarlyView.
Systematic neuropathological screening of 212 patients with Creutzfeldt–Jakob disease (55% women) identified chronic traumatic encephalopathy in three cases (1.4%), all men with a history of contact sports. These findings represent the first neuropathologically confirmed chronic traumatic encephalopathy cases reported in Spain.
Lluc Bertran   +13 more
wiley   +1 more source

Purkinje cell–specific deficiency in SEL1L-HRD1 endoplasmic reticulum–associated degradation causes progressive cerebellar ataxia in mice

open access: yesJCI Insight
Recent studies have identified multiple genetic variants of SEL1L-HRD1 endoplasmic reticulum–associated degradation (ERAD) in humans with neurodevelopmental disorders and locomotor dysfunctions, including ataxia.
Mauricio Torres   +7 more
doaj   +1 more source

Dendritic spike induction of postsynaptic cerebellar LTP [PDF]

open access: yes, 2008
The architecture of parallel fiber (PF) axons contacting cerebellar Purkinje neurons (PNs) retains spatial information over long distances. PF synapses can trigger local dendritic calcium spikes, but whether and how this calcium signal leads to plastic ...
Marco Canepari, Kaspar E. Vogt
core  

ON/OFF Phenomenon in 4‐Aminopyridine Therapy in Spinocerebellar Ataxia 27B: Therapeutic and Diagnostic Insights

open access: yes
Movement Disorders Clinical Practice, EarlyView.
Chiara Caneda   +6 more
wiley   +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

open access: yesThe FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi   +12 more
wiley   +1 more source

Biosynthesis and biological action of pineal allopregnanolone

open access: yesFrontiers in Cellular Neuroscience, 2014
The pineal gland transduces photoperiodic changes to the neuroendocrine system by rhythmic secretion of melatonin. We recently provided new evidence that the pineal gland is a major neurosteroidogenic organ and actively produces a variety of ...
Kazuyoshi eTsutsui, Shogo eHaraguchi
doaj   +1 more source

Staining of purkinje cells with anti-purvalbumin in cerebellar area.

open access: yes, 2016
The number of purkinje cells detected with anti-parvalbumin shows reduced number of positive cells in MO1 or MO2 injected embryos. (A, B and C): CMO injected fish, (D, E and F): MO1 injected fish, (G, H and I): MO2 injected fish.
Yukiko K. Hayashi (111828)   +1 more
core   +1 more source

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