Results 81 to 90 of about 12,043,245 (295)

Chronic sleep deprivation promotes drug‐resistant epilepsy via the BMAL1‐mTOR‐P‐gp axis

Epilepsia Open, EarlyView.
Abstract Objective The interplay between chronic sleep deprivation and drug‐resistant epilepsy (DRE) has gained increasing attention. Brain and muscle Arnt‐like protein 1 (BMAL1), which is implicated in sleep disturbance, has an unclear role in DRE. We aimed to investigate the role of BMAL1 in sleep deprivation‐induced DRE. Methods A pentylenetetrazole
Xiaomeng Wang, Rui Li, Yuzhu Zhang, Yi Hu, Jingjiao Chen, Sijia Tian, Dong Zhou, Xiaosa Chi   +7 more
wiley   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Purkinje cell-specific Grip1/2 knockout mice show increased repetitive self-grooming and enhanced mGluR5 signaling in cerebellum [PDF]

, 2019
Cerebellar Purkinje cell (PC) loss is a consistent pathological finding in autism. However, neural mechanisms of PC-dysfunction in autism remain poorly characterized.
Chiu, Shu-Ling, Gil Infante, Ana, Huganir, Richard L, Mejías Estévez, Rebeca María, Rose, Rebecca, Wang, Tao, Zhao, Yifan   +6 more
core   +1 more source

Intelligent Network Management and Functional Cerebellum Synthesis [PDF]

, 1989
Transdisciplinary modeling of the cerebellum across histology, physiology, and network engineering provides preliminary results at three organization levels: input/output links to central nervous system networks; links between the six neuron populations ...
Loebner, Egon E.
core   +1 more source

A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia [PDF]

, 2011
The purine adenosine plays an important role in a number of physiological and pathological processes and is neuroprotective during hypoxia and ischemia.
Atterbury, Alison, Wall, Mark J.
core   +1 more source

Movement Disorders Associated with 22q11.2 Microdeletion: A Scoping Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Movement disorders have recently emerged as important neurologic manifestations of the 22q11.2 microdeletion that affects nearly one in every 2000 live births. Objective We aimed to map the existing evidence regarding the spectrum, diagnosis and treatment, and etiopathogenesis of movement disorders associated with 22q11.2 ...
Nikolai Gil D. Reyes, Daniel G. Di Luca, Connie Marras, Erik Boot, Ryan K.C. Yuen, Anthony E. Lang, Anne S. Bassett   +6 more
wiley   +1 more source

A new approach for determining phase response curves reveals that Purkinje cells can act as perfect integrators.

PLoS Computational Biology, 2010
Cerebellar Purkinje cells display complex intrinsic dynamics. They fire spontaneously, exhibit bistability, and via mutual network interactions are involved in the generation of high frequency oscillations and travelling waves of activity.
Elena Phoka, Hermann Cuntz, Arnd Roth, Michael Häusser   +3 more
doaj   +1 more source

Experimentally-calibrated population of models predicts and explains inter-subject variability in cardiac cellular\ud electrophysiology [PDF]

, 2013
Cellular and ionic causes of variability in the electrophysiological activity of hearts from individuals of the same species are unknown. However, improved understanding of this variability is key to enable prediction of the response of specific hearts ...
Britton, O.J., Bueno-Orovio, A., Gallacher, D.J., Lu, H.R., Rodriguez, B., Towart, R., van Ammel, K.   +6 more
core   +1 more source

Differentiation of human induced pluripotent stem cells to mature functional Purkinje neurons

Scientific Reports, 2015
It remains a challenge to differentiate human induced pluripotent stem cells (iPSCs) or embryonic stem (ES) cells to Purkinje cells. In this study, we derived iPSCs from human fibroblasts and directed the specification of iPSCs first to Purkinje ...
Shuyan Wang, Bin Wang, N. Pan, L. Fu, Chaodong Wang, Gongru Song, J. An, Zhongfeng Liu, W. Zhu, Y. Guan, Z. Xu, Piu Chan, Zhiguo Chen, Y. Zhang   +13 more
semanticscholar   +1 more source

Convergence Deficits in Myoclonus‐Dystonia Point to Cerebellar Impairment

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Myoclonus‐dystonia (M‐D) is a monogenic movement disorder, with proposed cerebellar dysfunction. Vergence eye movement deficits, characteristics of degenerative cerebellar disease, have not been studied in M‐D. Cerebellar transcranial alternating current stimulation (tACS) is considered a potential therapeutic approach.
Skadi Gerkensmeier, Christina Bolte, Jan‐Ole Radecke, Feline Hamami, Andreas Sprenger, Christoph Helmchen, Robert Chen, Marcus Callister, Talyta Cortez Grippe, Christine Klein, Norbert Brüggemann, Tobias Bäumer, Alexander Münchau, Anne Weissbach   +13 more
wiley   +1 more source