Results 81 to 90 of about 4,781,201 (273)

Expanded ATXN3 CAG Repeat is Stable in Human Purkinje Cells

Movement Disorders, EarlyView.
Abstract Background Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disorder caused by an abnormally long polyglutamine‐encoding CAG repeat in the ATXN3 gene. Objectives We aimed to determine whether somatic expansion of the mutant ATXN3 (mATXN3) CAG repeat is present in the output cell of the cerebellar cortex, the Purkinje cell (PC), in ...
Hasnahana Chetia, Laura Kus, Erika Sipos, Nathaniel Heintz, Kert Mätlik   +4 more
wiley   +1 more source

Processing of Visual Signals Related to Self-motion in the Cerebellum of Pigeons

Frontiers in Behavioral Neuroscience, 2013
In this paper I describe the key features of optic flow processing in pigeons. Optic flow is the visual motion that occurs across the entire retina as a result of self-motion and is processed by subcortical visual pathways that project to the cerebellum.
Douglas Richard Wylie
doaj   +1 more source

Purkinje cell models: past, present and future

Frontiers in Computational Neuroscience
The investigation of the dynamics of Purkinje cell (PC) activity is crucial to unravel the role of the cerebellum in motor control, learning and cognitive processes. Within the cerebellar cortex (CC), these neurons receive all the incoming sensory and motor information, transform it and generate the entire cerebellar output.
Elías Mateo Fernández Santoro, Arun Karim, Pascal Warnaar, Pascal Warnaar, Chris I. De Zeeuw, Chris I. De Zeeuw, Aleksandra Badura, Mario Negrello   +7 more
openaire   +5 more sources

Structural Brain and Spinal Cord Signature of Spinocerebellar Ataxia 27B: A Multisite MRI‐Based Study

Movement Disorders, EarlyView.
Abstract Background SCA27B is a recently described ataxia, the precise anatomical basis of which remains unclear. Objective The goal was to characterize the structural brain and spinal cord magnetic resonance imaging (MRI) signature of spinocerebellar ataxia 27B (SCA27B) using multimodal quantitative imaging.
Nadson Bruno Serra Santos, Camila Caroso Lobo, Thiago Junqueira Ribeiro Rezende, Alberto Rolim Muro Martinez, Luiza A. Corazza, Luiz Eduardo Novis, Orlando Graziani Povoas Barsottini, José Luiz Pedroso, Pedro José Tomaselli, Wilson Marques Jr, Antônio Carlos dos Santos, David Pellerin, Bernard Brais, Roberta La Piana, Jemimah Harding, Penny Snell, Paul J. Lockhart, David Szmulewicz, Ian H. Harding, Marcondes Cavalcante França Jr   +19 more
wiley   +1 more source

Regularity, variabilty and bi-stability in the activity of cerebellar Purkinje cells

Frontiers in Cellular Neuroscience, 2009
Recent studies have demonstrated that the membrane potential of Purkinje cells is bi-stable and that this phenomenon underlies bi-modal simple spike firing.
Dan Rokni, Zohar Tal, Hananel Byk, Yosef Yarom   +3 more
doaj   +1 more source

FPGA‐Based Real‐Time Implementation of Closed‐Loop Brain‐Controlled Eye Movement System

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT This paper presents a comprehensive closed‐loop brain‐eye movement framework, spanning parametric modelling, dynamic analysis and real‐time FPGA implementation. A simplified first‐order oculomotor model was derived from the classical Robinson formulation to preserve the essential neural‐mechanical feedback structure while enabling efficient ...
Guodao Zhang, Yupeng Li, Yanjie Lu, Genfu Yang, Xiaotian Pan, Jing Wang   +5 more
wiley   +1 more source

A new approach for determining phase response curves reveals that Purkinje cells can act as perfect integrators.

PLoS Computational Biology, 2010
Cerebellar Purkinje cells display complex intrinsic dynamics. They fire spontaneously, exhibit bistability, and via mutual network interactions are involved in the generation of high frequency oscillations and travelling waves of activity.
Elena Phoka, Hermann Cuntz, Arnd Roth, Michael Häusser   +3 more
doaj   +1 more source

Abnormal struktur histologis korteks cerebellar tikus dengan normal foliasi akibat iradiasi sinar X masa postnatal

Journal of Biological Researches, 2012
Our previous experiment showed that prenatal exposure of rats to X-irradiation on gestation day 21st as the late gestation period causes heterotopic Purkinje cells and abnormal foliation of the cerebellum.
WIN DARMANTO
doaj   +1 more source

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source

Ataxic phenotype with altered CaV3.1 channel property in a mouse model for spinocerebellar ataxia 42

Neurobiology of Disease, 2019
Spinocerebellar ataxia 42 (SCA42) is a neurodegenerative disorder recently shown to be caused by c.5144G > A (p.Arg1715His) mutation in CACNA1G, which encodes the T-type voltage-gated calcium channel CaV3.1. Here, we describe a large Japanese family with
Shunta Hashiguchi, Hiroshi Doi, Misako Kunii, Yukihiro Nakamura, Misa Shimuta, Etsuko Suzuki, Shigeru Koyano, Masaki Okubo, Hitaru Kishida, Masaaki Shiina, Kazuhiro Ogata, Fumiko Hirashima, Yukichi Inoue, Shun Kubota, Noriko Hayashi, Haruko Nakamura, Keita Takahashi, Atsuko Katsumoto, Mikiko Tada, Kenichi Tanaka, Toshikuni Sasaoka, Satoko Miyatake, Noriko Miyake, Hirotomo Saitsu, Nozomu Sato, Kokoro Ozaki, Kiyobumi Ohta, Takanori Yokota, Hidehiro Mizusawa, Jun Mitsui, Hiroyuki Ishiura, Jun Yoshimura, Shinichi Morishita, Shoji Tsuji, Hideyuki Takeuchi, Kinya Ishikawa, Naomichi Matsumoto, Taro Ishikawa, Fumiaki Tanaka   +38 more
doaj   +1 more source